DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and M03D4.4

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001023313.1	Gene:	M03D4.4 / 177375	WormBaseID:	WBGene00019751	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	86/378 - (22%)
Similarity:	135/378 - (35%)	Gaps:	94/378 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 FRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQ---MTKTQKPDDD-LSQKQTLQ 146
            |..|::....|.:.|.....||:.:          ||.:|...   |.|.:..|.| ||...:.|
Worm    14 FHSLDELQRHEREEHETVEQGDQEE----------DRMEDDSDELAMIKIKIEDSDFLSDTDSSQ 68

  Fly   147 AKLQEGNIDGPPESFTLHPRKR-TCRTEEQADMIPKEATRSTKM-ICDADGYYNCPHCSKRFCSQ 209
            ..:   |...|.|..:...:.| .|  |:..:|...:...:|.| |...:..::|..|.|.|.::
Worm    69 LSM---NPTTPSEKSSSGEKGRYEC--EDCHEMFAVKRELATHMRIHSGEQPHSCTQCGKEFGTR 128

  Fly   210 TQLRT----HITDLCNRCPYCPRTYMQKSNLKRHLRNHLSKPAHKCFHCSKAFMRKDHLKRHLRT 270
            ..|:.    |..:..:.||:|.:.:.||.:|.:||..|.....|:|..|.|.|:.|..|.||::.
Worm   129 QLLKKHWMWHTGERSHVCPHCNKAFFQKGHLTQHLMIHSGGRPHECPQCHKTFIFKFDLNRHMKI 193

  Fly   271 HDSDGPLSCSQCSAVFIEHVQLEIHRREHKQRP--------------GSSKSESTKDPDSD---D 318
            |...| .||.||...|::.|.|:.|..:.|.:|              |...:.|.|.|...   .
Worm   194 HQERG-FSCQQCGRSFLKQVMLDEHHLKCKGKPSSPIRSLLTPTMKAGLESAISIKPPQESMILS 257

  Fly   319 SDQAQDLKPKW------------------------------TKNTFNGTC-------SIP-PMLK 345
            |:....:..|.                              ..|..||:.       .|| |.:.
Worm   258 SETIAKMAQKLLIQQQENHRNALNTLLVKQHENILNNNNNNESNILNGSVMHKDAGFEIPAPTIP 322

  Fly   346 PKPICDICQKKFSSVYALKRHMLTHN-------------RQHHLKKCTYCSEE 385
            ....|.||:.:|:|..:...||..|:             ..||..:.|..|.:
Worm   323 LSLTCMICKSQFNSQPSFTLHMYMHHIANQNPNLSIDSTHIHHTHQPTTISHQ 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871
		COG5048	220..>284	CDD:227381	24/63 (38%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		zf-C2H2	249..271	CDD:278523	9/21 (43%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	2/7 (29%)
		C2H2 Zn finger	406..427	CDD:275368
M03D4.4	NP_001023313.1	C2H2 Zn finger	90..110	CDD:275368	5/21 (24%)
		zf-H2C2_2	102..127	CDD:290200	7/24 (29%)
		C2H2 Zn finger	118..138	CDD:275368	5/19 (26%)
		C2H2 Zn finger	146..166	CDD:275368	8/19 (42%)
		zf-H2C2_2	158..181	CDD:290200	8/22 (36%)
		zf-C2H2	172..194	CDD:278523	9/21 (43%)
		C2H2 Zn finger	174..194	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000