DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and ZNF497

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001193938.1	Gene:	ZNF497 / 162968	HGNCID:	23714	Length:	498	Species:	Homo sapiens

Alignment Length:	443	Identity:	107/443 - (24%)
Similarity:	155/443 - (34%)	Gaps:	119/443 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PVLDEPEMSLSHILARCTE--RPVKRGDLLPQ----------FICVSCVLAVQNAFRFKWQSEQS 81
            |:.:||.       .||.|  :...:|..|.|          :.|..|..|      |.|.|..|
Human    99 PLPEEPG-------CRCGECGKAFSQGSYLLQHRRVHTGEKPYTCPECGKA------FAWSSNLS 150

  Fly    82 YQHFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKPDDDLSQKQTLQ 146
             ||            .::|    :|:|              ....::..|..:....|...|...
Human   151 -QH------------QRIH----SGEK--------------PYACRECGKAFRAHSQLIHHQETH 184

  Fly   147 AKLQEGNIDGPPESF----TLHPRKRTCRTEEQADMIPKEATRSTKMICDADGYYNCPHCSKRFC 207
            :.|:........:||    ||...:||...|:.                     |.||.|.|.|.
Human   185 SGLKPFRCPDCGKSFGRSTTLVQHRRTHTGEKP---------------------YECPECGKAFS 228

  Fly   208 SQTQL----RTHITDLCNRCPYCPRTYMQKSNLKRHLRNHLSKPAHKCFHCSKAFMRKDHLKRHL 268
            ..:..    |.|.....:.|..|.:.:.|.|||..||:.|.....|.|..|.|||:|...|::|.
Human   229 WNSNFLEHRRVHTGARPHACRDCGKAFSQSSNLAEHLKIHAGARPHACPDCGKAFVRVAGLRQHR 293

  Fly   269 RTHDSDGPLSCSQCSAVFIEHVQLEIHRREHK-QRP------------GSSKSESTKDPDSDDSD 320
            |||.|:.|..|::|...|.|..||..|:|.|. :||            ||..:|..:....:...
Human   294 RTHSSEKPFPCAECGKAFRESSQLLQHQRTHTGERPFECAECGQAFVMGSYLAEHRRVHTGEKPH 358

  Fly   321 QAQDLKPKWT--------KNTFNGTCSIPPMLKPKPI-CDICQKKFSSVYALKRHMLTHNRQHHL 376
            ........::        :.|.:|.         ||. |..|.|.|.....|..|.|:|..:...
Human   359 ACAQCGKAFSQRSNLLSHRRTHSGA---------KPFACADCGKAFRGSSGLAHHRLSHTGERPF 414

  Fly   377 KKCTYCSEEFKTEKHLKRHERGHMGDL-FRCEFCSLVFVDVNYLRKHKKRIHS 428
             .|..|.:.|:....|::|:|.|.|:. |.|..||..||..:.|..| :|.|:
Human   415 -ACAECGKAFRGSSELRQHQRLHSGERPFVCAHCSKAFVRKSELLSH-RRTHT 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	17/67 (25%)
		COG5048	220..>284	CDD:227381	25/63 (40%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		zf-C2H2	249..271	CDD:278523	10/21 (48%)
		C2H2 Zn finger	251..271	CDD:275368	9/19 (47%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		C2H2 Zn finger	406..427	CDD:275368	8/20 (40%)
ZNF497	NP_001193938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..104		1/4 (25%)
		COG5048	107..492	CDD:227381	104/428 (24%)
		C2H2 Zn finger	108..128	CDD:275368	5/19 (26%)
		zf-H2C2_2	120..144	CDD:290200	5/29 (17%)
		C2H2 Zn finger	136..156	CDD:275368	9/38 (24%)
		zf-H2C2_2	148..171	CDD:290200	7/53 (13%)
		C2H2 Zn finger	164..184	CDD:275368	3/19 (16%)
		zf-C2H2	190..212	CDD:278523	5/21 (24%)
		C2H2 Zn finger	192..212	CDD:275368	5/19 (26%)
		zf-H2C2_2	205..228	CDD:290200	9/43 (21%)
		C2H2 Zn finger	220..240	CDD:275368	6/19 (32%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..296	CDD:275368	9/19 (47%)
		zf-H2C2_2	289..311	CDD:290200	9/21 (43%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-H2C2_2	317..340	CDD:290200	6/22 (27%)
		C2H2 Zn finger	332..352	CDD:275368	3/19 (16%)
		zf-H2C2_2	344..369	CDD:290200	1/24 (4%)
		C2H2 Zn finger	360..380	CDD:275368	0/19 (0%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..453	CDD:290200	10/24 (42%)
		C2H2 Zn finger	444..464	CDD:275368	8/20 (40%)
		zf-H2C2_2	456..481	CDD:290200	4/11 (36%)
		C2H2 Zn finger	472..492	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910