DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and AgaP_AGAP009120

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	XP_319872.4	Gene:	AgaP_AGAP009120 / 1280072	VectorBaseID:	AGAP009120	Length:	321	Species:	Anopheles gambiae

Alignment Length:	423	Identity:	86/423 - (20%)
Similarity:	140/423 - (33%)	Gaps:	125/423 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VCRTCMD--ETGTLVDIFANVRDPVLDEPEMSLSHILARCTERPVKRGDLLPQFICVSCVLAVQN 70
            :||.|:.  :.|:.||:||      ::...:|...::.||....:...|..|..||..|...::.
Mosquito     6 ICRLCLQGLQDGSCVDLFA------INHLSVSPLAMITRCASIQIYEKDGFPTTICNDCYCKLEM 64

  Fly    71 AFRFKWQSEQSYQHFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKP 135
            |:.|:.:.|.|.|....:||.....:...|      .|.:||.||...:.......::.|..:..
Mosquito    65 AYEFRNRCEASDQKLREMLNIPTGNDKSAH------TKVKIICQKRAARKQPMLGRKRATAKENQ 123

  Fly   136 DDDLSQKQTLQAKLQEGNIDGPPESFTLHPRKRTCRTEEQADMIPKEATRSTKMICDADGYYNCP 200
            :    |:|..|.:.|.|                                       ||:..:.|.
Mosquito   124 E----QQQQQQQETQPG---------------------------------------DAENPFQCT 145

  Fly   201 HCSKRFCSQTQLRTHITDLCNRCPYCPRTYMQKSNLKRHLRNHLSKPAHKCFHCSKAFMRKDHLK 265
            .|.:||              ||.          .||:.|:|.|.::...:|..|||.|....:|.
Mosquito   146 VCQRRF--------------NRA----------GNLRLHMRVHSNERQFQCEICSKLFRTSSNLH 186

  Fly   266 RHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRREHKQRPGSSKSESTKDPDSDDSDQAQDLKPKWT 330
            .|.:||..:....|:.|...|....:|..|.:.|....|.
Mosquito   187 AHRKTHTDERNFPCTVCERAFRTARELVSHGKTHSDVKGY------------------------- 226

  Fly   331 KNTFNGTCSIPPMLKPKPICDICQKKFSSVYALKRHMLTHNRQHHLKKCTYCSEEFKTEKHLKRH 395
                              :|.:|.|.|.....|..||.|.:......:|..|.::|....:|..|
Mosquito   227 ------------------VCRVCSKGFVKQSYLNTHMNTVHVGLKRYRCQECGKQFSNSSNLIAH 273

  Fly   396 ERGHMGDL-FRCEFCSLVFVDVNYLRKHKKRIH 427
            .|.|.|:. ::|..|...|...:.|.:|.::.|
Mosquito   274 RRVHTGEKPYKCGECDGKFNQSSALTRHIRQQH 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	21/78 (27%)
		COG5048	220..>284	CDD:227381	18/63 (29%)
		C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		zf-C2H2	249..271	CDD:278523	7/21 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		C2H2 Zn finger	406..427	CDD:275368	5/20 (25%)
AgaP_AGAP009120	XP_319872.4	zf-AD	6..81	CDD:214871	21/80 (26%)
		COG5048	<140..304	CDD:227381	48/230 (21%)
		C2H2 Zn finger	144..164	CDD:275368	10/43 (23%)
		zf-H2C2_2	156..181	CDD:290200	10/24 (42%)
		C2H2 Zn finger	172..192	CDD:275368	7/19 (37%)
		C2H2 Zn finger	200..220	CDD:275368	5/19 (26%)
		C2H2 Zn finger	228..249	CDD:275368	8/20 (40%)
		zf-C2H2	255..277	CDD:278523	6/21 (29%)
		C2H2 Zn finger	257..277	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..294	CDD:290200	8/24 (33%)
		C2H2 Zn finger	285..303	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870