DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and AgaP_AGAP009068

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	XP_319817.4	Gene:	AgaP_AGAP009068 / 1280023	VectorBaseID:	AGAP009068	Length:	619	Species:	Anopheles gambiae

Alignment Length:	534	Identity:	115/534 - (21%)
Similarity:	192/534 - (35%)	Gaps:	156/534 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VCRTCM----DETGTLVDIFANVRDPVLDEPEMSLSHILARCTERPVKRGDLLPQFICVSCVLAV 68
            |||.||    |:...:.|.|.:|          .||.::..|....:::.|.||:..|.:|...:
Mosquito    13 VCRICMESCEDDCVCVYDEFEDV----------LLSDVIRECARVEIRKNDALPRNACRNCAEYL 67

  Fly    69 QNAFRFKWQSEQS-------YQHFFRVLNQSGAPENQ--VHLAA------------CNG-DKNQI 111
            ..|:....:...|       ::|...:..:...|...  |.|.|            .|| |...:
Mosquito    68 IIAYHIIQKCRDSDVTLRSIFKHELNLHREERKPNTSSVVGLRADDMDPSGYEFLLANGYDTMML 132

  Fly   112 INQKMQLK---------SDRQQDTQQMTKTQKPDDDLSQKQTLQAKLQEGNIDGPPESFTLHPRK 167
            ..:.|.|:         ||.:.|:     .|:.:..|:.::.:..:....:.:...|..:.:.:|
Mosquito   133 EGEGMLLENADCDFTAPSDEKADS-----VQEEEKALAARRLVTGETVHESSETTEEDGSCNEQK 192

  Fly   168 RTC------------RTEEQADMIPKEATRSTKMICDADG------YYNCPHCSKRFCSQTQLRT 214
            :.|            |...|...:|.|::.|       ||      ...||.|.|||.|:..|:.
Mosquito   193 KCCGCRKLFSSEQSLREHCQTVHLPVESSAS-------DGPASESKPIRCPVCFKRFSSRQLLKE 250

  Fly   215 HITDLCNR---CPYCPRTYMQKSNLKRHLRNHLSKPAHKCFHCSKAF-------MRKDHLKRHLR 269
            |...: ||   |..|.:.:|.::||..|.:.|.:|..:||..|...|       :...::.|..|
Mosquito   251 HERSV-NRKYVCAQCGKRFMTQANLDTHTKCHKNKETYKCCGCRMDFEQELDLLVHSQNVHRLER 314

  Fly   270 THDSDGPLSCSQ-------------------------CSAVFIEHVQLEI-HRREHKQRPGSSK- 307
            :.|.|.|..|..                         |.|:|::.:.|:: |.|.|:|.....:
Mosquito   315 SVDPDKPFECDTCYRRYPTRKSLATHKRQIRQFQCPLCGAMFMKQLFLQLHHERAHQQEAQEKRR 379

  Fly   308 -------------------SESTKDP-DSDDSDQAQDLKPKWTKNTFNGTCSIPPMLKPKPICDI 352
                               ||....| |........|.||      |.              |::
Mosquito   380 RCCGGCREVFENAAALRAHSERVHKPADGSAGSGTDDGKP------FE--------------CNV 424

  Fly   353 CQKKFSSVYALKRHMLTHNRQHHLKKCTYCSEEFKTEKHLKRHERGHMGDL-FRCEFCSLVFVDV 416
            |:|:|:|::.|.:|.....|: ....||.|...|.....|..||..|..:: |.|..||..|.:.
Mosquito   425 CRKRFASIFFLLQHQQKVARE-KCYPCTVCGRTFGRAHDLSNHETTHSNEMPFECSVCSRRFKNK 488

  Fly   417 NYLRKHKKRIHSNN 430
            .||:.|.| :|:::
Mosquito   489 LYLKNHLK-LHASS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	19/87 (22%)
		COG5048	220..>284	CDD:227381	21/98 (21%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		zf-C2H2	249..271	CDD:278523	6/28 (21%)
		C2H2 Zn finger	251..271	CDD:275368	5/26 (19%)
		C2H2 Zn finger	279..299	CDD:275368	7/45 (16%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..427	CDD:275368	8/20 (40%)
AgaP_AGAP009068	XP_319817.4	zf-AD	13..86	CDD:214871	19/82 (23%)
		COG5048	<150..400	CDD:227381	52/262 (20%)
		C2H2 Zn finger	194..215	CDD:275368	3/20 (15%)
		C2H2 Zn finger	235..253	CDD:275368	9/17 (53%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..310	CDD:275368	3/20 (15%)
		C2H2 Zn finger	324..342	CDD:275368	1/17 (6%)
		C2H2 Zn finger	349..370	CDD:275368	6/20 (30%)
		C2H2 Zn finger	382..403	CDD:275368	2/20 (10%)
		C2H2 Zn finger	422..442	CDD:275368	7/19 (37%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		C2H2 Zn finger	478..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	507..527	CDD:275368
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		C2H2 Zn finger	594..612	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910