DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and znf628

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	XP_002941933.2	Gene:	znf628 / 100489381	XenbaseID:	XB-GENE-5996090	Length:	1095	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	110/521 - (21%)
Similarity:	162/521 - (31%)	Gaps:	197/521 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LSHILARCTERP---------VKRGDLL----------PQFICVSCVLAVQNAFRFKWQSEQSYQ 83
            |.|..:...|||         .||..||          ..|.|..|.:|      |||.|.  ||
Frog    76 LYHQRSHTGERPYKCESCGKAFKRSSLLQIHQSVHTGVKSFKCNICGMA------FKWSSH--YQ 132

  Fly    84 HFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKPDDDLSQKQTLQAK 148
            :..|                             |...:|........|..|....|.
Frog   133 YHVR-----------------------------QHTGERPYQCNVCEKAFKNSSSLR-------- 160

  Fly   149 LQEGNIDGPPESFTLHPRKRTCRTEE---QADMIPKEATRSTKM-----ICDADGYYNCPHCSKR 205
                             |.|...|.|   :..:..|..|:||.:     |...:..|.|..|.|.
Frog   161 -----------------RHRNIHTGERPYECAICGKAFTQSTNLRQHQRIHTGERPYKCEDCGKS 208

  Fly   206 FCSQTQL----RTHITDLCNRCPYCPRTYMQKSNLKRHLRNHLSKPA------------------ 248
            |...:.|    |||...:.::|..|.:.::..|.|::||::|..:.|
Frog   209 FTHSSNLLLHQRTHSAGVSHKCEICGKVFISDSFLQKHLQSHAIEQAFVHAEAEVYLTTTAAVET 273

  Fly   249 -------------------------------HKCFHCSKAFMRKDHLKRH-LRTHDSDGPLSCSQ 281
                                           :.|.:|.|.|.....|.|| ...|.|:.|..||.
Frog   274 VEMVFKCGDCEMTFKNEDLLLGHQQTHVEQIYPCTNCDKTFKNPSGLSRHNQHCHSSERPFKCSI 338

  Fly   282 CSAVFIEHVQLEIHRREHKQR------------PGSSK--SESTKDPDSDDSDQAQDLKPKWTK- 331
            |...|::...|.:|:|.|.:.            |.:|:  ..||..|.::..|:    :.|.|:
Frog   339 CEKTFVQLSNLLVHQRTHTEEQQFIQTEAEVTCPQTSEIIQPSTATPATETVDR----QYKCTEC 399

  Fly   332 -NTFNGTCSIPPMLK----PKPI-CDICQKKFSSVYALKRHMLTH-------------------N 371
             ..|.||..:...::    .:|. |..|.|.|.....|..|...|                   :
Frog   400 GKVFKGTSGLRYHMRDHTGERPYKCSECGKAFKRSSLLSIHQRVHTGVRAFKCAECGLTFKWSSH 464

  Fly   372 RQHHLKK--------CTYCSEEFKTEKHLKRHERGHMGDL-FRCEFCSLVFVDVNYLRKHKKRIH 427
            .|:||::        ||.|.:.||....|:||.:.|.|:. |.|..|...|...:.||:| :|.|
Frog   465 YQYHLRQHTGERPYTCTDCGKSFKNTSCLRRHRQLHTGERPFTCLMCGKTFTQTSNLRQH-ERTH 528

  Fly   428 S 428
            :
Frog   529 T 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	19/65 (29%)
		COG5048	220..>284	CDD:227381	21/113 (19%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		zf-C2H2	249..271	CDD:278523	7/22 (32%)
		C2H2 Zn finger	251..271	CDD:275368	7/20 (35%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	406..427	CDD:275368	7/20 (35%)
znf628	XP_002941933.2	C2H2 Zn finger	34..54	CDD:275368
		zf-H2C2_2	46..70	CDD:404364
		C2H2 Zn finger	62..82	CDD:275368	2/5 (40%)
		zf-H2C2_2	74..99	CDD:404364	5/22 (23%)
		C2H2 Zn finger	90..110	CDD:275368	4/19 (21%)
		C2H2 Zn finger	118..138	CDD:275368	10/56 (18%)
		COG5048	142..576	CDD:227381	89/418 (21%)
		C2H2 Zn finger	146..166	CDD:275368	5/44 (11%)
		C2H2 Zn finger	174..194	CDD:275368	4/19 (21%)
		C2H2 Zn finger	202..222	CDD:275368	6/19 (32%)
		C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	280..300	CDD:275368	0/19 (0%)
		C2H2 Zn finger	307..328	CDD:275370	7/20 (35%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		C2H2 Zn finger	396..416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	452..472	CDD:275368	3/19 (16%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		C2H2 Zn finger	508..528	CDD:275368	7/20 (35%)
		C2H2 Zn finger	536..556	CDD:275368
		C2H2 Zn finger	564..584	CDD:275368
		SP1-4_N	<586..>840	CDD:425404
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910