Protein Alignment EMC1 and EMC1

DIOPT Version :9

• Sequence 1: NP_001287215.1
• Gene: EMC1 / 40933
• FlyBaseID: FBgn0037530
• Length: 915
• Species: Drosophila melanogaster
• Sequence 2: NP_009884.1
• Gene: EMC1 / 850312
• SGDID: S000000550
• Length: 760
• Species: Saccharomyces cerevisiae
• Alignment Length: 678
• Identity: 172/678 - (25%)
• Similarity: 299/678 - (44%)
• Gaps: 128/678 - (18%)

  Fly   297 LRINALY-LDNCAPAAELEQSLPFPEHFGTPSLSNFDCKQKRNGEGKNCLFL---------FSST 351
            ::.|.|: ||..:..||.:..||          ..|:..:..:.|....|.|         ||:.
Yeast   148 IKNNELHILDEQSKLAEWKLELP----------QGFNKVEYFHREDPLALVLNVNDTQYMGFSAN 202

  Fly   352 SESIVAVQHGRVRWSREESLANVIDSQFVDL-PLADTEGTLENEMKGKAGDFTSFERDIASAFLR 415
            ...::.|      |.|:|.|.||:|...:|: ...|.|  |..:||.:..     ...:.:|:..
Yeast   203 GTELIPV------WQRDEWLTNVVDYAVLDVFDSRDVE--LNKDMKAELD-----SNSLWNAYWL 254

  Fly   416 RITTQAVQIRSL-----------FLHVIGLGPPPTDTQRAGLVRD-SFGLHKMLVLLTRAGKIFG 468
            |:||...::.:|           |..::.|....|      .|.| .||..|:|::||..|.|.|
Yeast   255 RLTTNWNRLINLLKENQFSPGRVFTKLLALDAKDT------TVSDLKFGFAKILIVLTHDGFIGG 313

  Fly   469 IDNVS-GKHHWQLHL---PNVIGFANDEQM-RLIVQRSAKHFPLQPLCTILGKNAVSGNGVLYRF 528
            :|.|: |:..|:|.|   ..|..|..|:.. .|:|.....|:        |.........::...
Yeast   314 LDMVNKGQLIWKLDLEIDQGVKMFWTDKNHDELVVFSHDGHY--------LTIEVTKDQPIIKSR 370

  Fly   529 NPITGKVAEGGLVQLDYRIKQLSLLGETEKDFLKGILLLDASNKVHVYPEHAAPLA----DGMYL 589
            :|::.:.....:::|:....|. |:...:||.|  :..|:......|      |:.    ...::
Yeast   371 SPLSERKTVDSVIRLNEHDHQY-LIKFEDKDHL--LFKLNPGKNTDV------PIVANNHSSSHI 426

  Fly   590 YTADLKTAELAGYFVKYAGGQLSSTHIWNARLGGHNSEQQIIGVAGKNPIEHVHSQGRVLGDRSV 654
            :..:..|..:.||.::  ...:..|  |...:   ||:::::..: |....::::.|..|||:||
Yeast   427 FVTEHDTNGIYGYIIE--NDTVKQT--WKKAV---NSKEKMVAYS-KRETTNLNTLGITLGDKSV 483

  Fly   655 LYKYINPNLVAFVTQAPDSTHKSVLNLYLVDVVSGSVVFTMTHR---KVRAPLSIVHSENWLAYS 716
            ||||:.|||.|::. |.:..|....|  |:|.::|.::.|..|:   ..|.|:.||..|.|:.||
Yeast   484 LYKYLYPNLAAYLI-ANEEHHTITFN--LIDTITGEILITQEHKDSPDFRFPMDIVFGEYWVVYS 545

  Fly   717 YF-NEKLRRTEITTIELYEG----KSQANSSVWSSLQAPPM------PLVERQSYILPTIVEALR 770
            || :|.:...::..:||||.    :..:|||  .:....|:      |..:.:.:|.|.|::.:.
Yeast   546 YFSSEPVPEQKLVVVELYESLTPDERLSNSS--DNFSYDPLTGHINKPQFQTKQFIFPEIIKTMS 608

  Fly   771 ETITERGITNKHVLIGTASGSIVEMPWHLLDPR-RPIASTTQGREEG--AIPYIPELPLPTESHI 832
            .:.|...||.|.:::...:|.|..:|..||:.| :|.....:.:::.  |.||.|.:|      |
Yeast   609 ISKTTDDITTKAIVMELENGQITYIPKLLLNARGKPAEEMAKDKKKEFMATPYTPVIP------I 667

  Fly   833 NYNQTVARLRN--------IYTAPSGLESTCLVVATGLDLFVTRVAPSKTFDLLKEDFD--YILI 887
            |.|..:...||        :.:.|:.||||.::...|||:|.||:.||..|||:...|:  .:||
Yeast   668 NDNFIITHFRNLLPGSDSQLISIPTNLESTSIICDLGLDVFCTRITPSGQFDLMSPTFEKGKLLI 732

  Fly   888 SI-VLVALTSGSLIVKHLASRKLLKQAW 914
            :| ||:.:|   ..::...|.|.||..|
Yeast   733 TIFVLLVIT---YFIRPSVSNKKLKSQW 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EMC1	NP_001287215.1	DUF1620	709..914	CDD:285069	67/229 (29%)
EMC1	NP_009884.1	GyrA	<279..467	CDD:223266	41/197 (21%)
		DUF1620	538..757	CDD:400226	70/246 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343290
Domainoid	1	1.000	85	1.000	Domainoid score	I1904
eggNOG	1	0.900	-	-		E1_KOG2103
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I1155
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004336
OrthoInspector	1	1.000	-	-		oto99064
orthoMCL	1	0.900	-	-		OOG6_102462
Panther	1	1.100	-	-	LDO	PTHR21573
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R394
SonicParanoid	1	1.000	-	-		X3060
TreeFam	0	0.000	Not matched by this tool.
	11	10.820