Protein Alignment EMC1 and Emc1

DIOPT Version :10

• Sequence 1: NP_649747.1
• Gene: EMC1 / 40933
• FlyBaseID: FBgn0037530
• Length: 915
• Species: Drosophila melanogaster
• Sequence 2: NP_001102160.1
• Gene: Emc1 / 362643
• RGDID: 1310427
• Length: 993
• Species: Rattus norvegicus
• Alignment Length: 1049
• Identity: 354/1049 - (33%)
• Similarity: 506/1049 - (48%)
• Gaps: 197/1049 - (18%)

  Fly     3 EKWLLPALSLALLLGTCSALYEDQIKKFDWRGVNVGALKQSRVDLNHFQPRILVTTYEGVVASLC 67
            |.|.   ...|:||...:|:||||:.|||||...||.||.:.::.:....:::|.|.:.|:|:|.
  Rat     6 ESWF---CLCAVLLVPAAAVYEDQVGKFDWRQQYVGKLKFASLEFSPGSKKLVVATEKNVIAALN 67

  Fly    68 VKTGELVWRQVLEQKPRGDVKLLQVSGFADDSSDTAAAPMGSNMGFDMLTVQGHAPALVRGWNTN 132
            .:|||::||.|.:....|.|..:.|.                  |.|.:|| .:...::|.|.||
  Rat    68 SRTGEILWRHVDKGTAEGAVDAMLVH------------------GQDAITV-SNGGRIMRSWETN 113

  Fly   133 MGALEWE-----WSIMPMNTERAQDAM----------------------WI----YSKSVLYHVL 166
            :|.|.||     .|...:.....|:.:                      |:    .|.|:||.::
  Rat   114 IGGLNWEITLDSGSFQALGLVGLQETVRYVAVLKKTTLTLHHLSSGHLKWVEHLPESDSILYQMV 178

  Fly   167 ------PAWR------SHLEVTAYFASSGHSTGSTSKVIAPW---ITSESCTLSGTFYVCTDGKQ 216
                  ..|.      ||:.:..:....|...... :|..||   :|.....:.....||.|...
  Rat   179 YSYGSGVVWALGIVPFSHVNIVKFNVEDGEIVQQV-RVWTPWLQHLTGACGVVDEAVLVCPDPSS 242

  Fly   217 ------------------LISLDLVSKSG---QVIRTS------------LEAEP---------- 238
                              |.|.||...||   ||:.|.            |:..|
  Rat   243 HSLHTLALETEWELRQIPLQSPDLEFGSGFQPQVLPTQPSPVAPSRAQFFLQLSPGHYALLHYHH 307

  Fly   239 ------KGKTQ------ALTGLNGVVIVDGKPISVNKDQSICGDLRSSSF--------AVGSFN- 282
                  |...|      |.||...|..|......|.|..| .||...:||        ::..||
  Rat   308 GAVTLLKNFPQATLVSFATTGEKTVAAVMTCRTEVQKPGS-AGDGSVASFPETSGAQDSLACFNQ 371

  Fly   283 -YRKVLAYADLSSGILRINALYLDNCAPAAELEQSLPFPEHFGTPSLSNFDCKQKRNGEGKNCLF 346
             |...|...:....:|..:..:        .|||....||.......     .:|.:..|...|.
  Rat   372 TYTINLYLVETGRRLLDTSISF--------SLEQKGTRPEQLYVQVF-----LKKDDSVGYRALV 423

  Fly   347 LFSSTSESIVAVQHGR-VRWSREESLANVIDSQFVDLPLADTEGTLENEMKGKAGDFTSFERDIA 410
            ......:..:....|: |.||||||||.|:..:.|||||...:..||.|. ||..|      .:.
  Rat   424 QTQDHLQLFLQQLAGKVVLWSREESLAEVVCLEMVDLPLTGAQAELEGEF-GKKAD------GLL 481

  Fly   411 SAFLRRITTQAVQIRSLFLHV-----------------IGLGPPPTDTQRAGLVRDSFGLHKMLV 458
            ..||:|:::|.:.:::...|:                 |.:     ||    |.||.|.|.||:|
  Rat   482 GMFLKRLSSQLILLQAWTSHLWKMFYDARKPRSQIKNEINI-----DT----LARDEFNLQKMMV 537

  Fly   459 LLTRAGKIFGIDNVSGKHHWQLHLPNVIGFANDEQMRLIVQRSAKHFPLQPLCTILGKNAVSGNG 523
            ::|.:||:|||::.||...|:.:||||   ..|...:|:|||:..|||..|.||:|.|:..:|..
  Rat   538 MVTASGKLFGIESSSGTILWKQYLPNV---KPDSSFKLMVQRTTAHFPHPPQCTLLVKDKETGMS 599

  Fly   524 VLYRFNPITGKVAEGGLVQLDYRIKQLSLLGETEKDFLKGILLLDASNKVHVYP------EHAAP 582
            .|:.||||.||.::.....|...|.|..||...::|:.|.:||:|...||..:|      .....
  Rat   600 SLFVFNPIFGKWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLVDDEYKVTAFPATRNVLRQLHE 664

  Fly   583 LADGMYLYTADLKTAELAGYFVKYAGGQLSSTHIWNARLGGHNSEQQIIGVAGKNPIEHVHSQGR 647
            ||..::.|..|.:...|:||.::   ..|::...|...:  ....|:::.|.||...||||||||
  Rat   665 LAPSIFFYLVDAEQGRLSGYRLR---KDLTTELSWELII--PPEVQRVVQVKGKRSSEHVHSQGR 724

  Fly   648 VLGDRSVLYKYINPNLVAFVTQAPDSTH-KSVLNLYLVDVVSGSVVFTMTHRKVRAPLSIVHSEN 711
            |:||||||||.:||||:|.||::.|..| ::.:.::|:|.|:|.::.:...:|.|.|:.:|||||
  Rat   725 VMGDRSVLYKSLNPNLLAVVTESTDVHHERTFIGIFLIDGVTGRIIHSSVQKKARGPVHLVHSEN 789

  Fly   712 WLAYSYFNEKLRRTEITTIELYEGKSQANSSVWSSLQAPPMPLVERQSYILPTIVEALRETITER 776
            |:.|.|:|.|.||.|:|.:|||||..|.|::.:|||..|.:|.|.:||||.|:.:.|:..|||||
  Rat   790 WVVYQYWNSKARRNELTALELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITER 854

  Fly   777 GITNKHVLIGTASGSIVEMPWHLLDPRRPIASTTQGREEGAIPYIPELPLPTESHINYNQTVARL 841
            |||::|:|||..||:|:.:|..|||||||...|.|.|||..|||.|::.:..|..|||||||:|:
  Rat   855 GITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQVHAERFINYNQTVSRM 919

  Fly   842 RNIYTAPSGLESTCLVVATGLDLFVTRVAPSKTFDLLKEDFDYILISIVLVALTSGSLIVKHLAS 906
            |.||||||||||||||||.|||::.|||.|||.||:||:|:||:|||.||..|...::|.|.||.
  Rat   920 RGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGLVFATMITKRLAQ 984

  Fly   907 RKLLKQAWK 915
            .|||.:||:
  Rat   985 VKLLNRAWR 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EMC1	NP_649747.1	EMC1_C	709..914	CDD:462261	118/204 (58%)
Emc1	NP_001102160.1	PQQ_2	59..>212	CDD:433144	35/171 (20%)
		EMC1_C	787..992	CDD:462261	118/204 (58%)