Protein Alignment EMC1 and Emc1

DIOPT Version :10

• Sequence 1: NP_649747.1
• Gene: EMC1 / 40933
• FlyBaseID: FBgn0037530
• Length: 915
• Species: Drosophila melanogaster
• Sequence 2: NP_666269.2
• Gene: Emc1 / 230866
• MGIID: 2443696
• Length: 997
• Species: Mus musculus
• Alignment Length: 1039
• Identity: 352/1039 - (33%)
• Similarity: 507/1039 - (48%)
• Gaps: 191/1039 - (18%)

  Fly    13 ALLLGTCSALYEDQIKKFDWRGVNVGALKQSRVDLNHFQPRILVTTYEGVVASLCVKTGELVWRQ 77
            |:||...:|:||||:.|||||...||.:|.:.::.:....:::|.|.:.|:|:|..:|||::||.
Mouse    14 AVLLVPAAAVYEDQVGKFDWRQQYVGKIKFASLEFSPGSKKLVVATEKNVIAALNSRTGEILWRH 78

  Fly    78 VLEQKPRGDVKLLQVSGFADDSSDTAAAPMGSNMGFDMLTVQGHAPALVRGWNTNMGALEWE--- 139
            |.:....|.|..:.|.                  |.|.:|| .:...|:|.|.||:|.|.||
Mouse    79 VDKGTAEGAVDAMLVH------------------GQDAITV-SNGGRLMRSWETNIGGLNWEITL 124

  Fly   140 --WSIMPMNTERAQDAM----------------------WI----YSKSVLYHVL------PAWR 170
              .|...:.....|:::                      |:    .|.|:||.::      ..|.
Mouse   125 DTGSFQALGLVGLQESVRYIAVLKKTTLTLHHLSSGHLKWVEHLPESDSILYQMVYSYGSGVVWA 189

  Fly   171 ------SHLEVTAYFASSGHSTGSTSKVIAPW---ITSESCTLSGTFYVCTDGKQ---------- 216
                  ||:.:..:....|...... :|..||   :|.....:.....||.|...
Mouse   190 LGIVPFSHVNIVKFNVEDGEIVQQV-RVWTPWLQHLTGACGVVDEAVLVCPDPSSHSLHTLALET 253

  Fly   217 --------LISLDLVSKSG---QVIRTS------------LEAEP----------------KGKT 242
                    |.|.||...||   ||:.|.            |:..|                |...
Mouse   254 EWELRQIPLQSPDLEFGSGFQPQVLPTQPSPVAPSRAQFFLQLSPSHYALLHYHHGAVTLLKNFP 318

  Fly   243 Q------ALTGLNGVVIVDGKPISVNKDQSICGDLRSSSF--------AVGSFN--YRKVLAYAD 291
            |      |.||...|..|......|.|..| .||...:||        ::..||  |...|...:
Mouse   319 QATLVSFATTGEKTVAAVMTCRTEVQKPVS-AGDGSVASFPETSGAQDSLACFNQTYTINLYLVE 382

  Fly   292 LSSGILRINALYLDNCAPAAELEQSLPFPEHFGTPSLSNFDCKQKRNGEGKNCLFLFSSTSESIV 356
            ....:|..:..:        .|||....||..   .:..|  .:|.:..|...|.......:..:
Mouse   383 TGRRLLDTSISF--------SLEQKGTRPEQL---YIQVF--LKKDDSVGYRALVQTQDHLQLFL 434

  Fly   357 AVQHGR-VRWSREESLANVIDSQFVDLPLADTEGTLENEMKGKAGDFTSFERDIASAFLRRITTQ 420
            ....|: |.||||||||.|:..:.|||||...:..||.|...||    :.:..:...||:|:::|
Mouse   435 QQLAGKVVLWSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKA----AIQDGLLGMFLKRLSSQ 495

  Fly   421 AVQIRSLFLHV-----------------IGLGPPPTDTQRAGLVRDSFGLHKMLVLLTRAGKIFG 468
            .:.:::...|:                 |.:     ||    |.||.|.|.||:|.:|.:||:||
Mouse   496 LILLQAWTSHLWKMFYDARKPRSQIKNEINI-----DT----LARDEFNLQKMMVTVTASGKLFG 551

  Fly   469 IDNVSGKHHWQLHLPNVIGFANDEQMRLIVQRSAKHFPLQPLCTILGKNAVSGNGVLYRFNPITG 533
            |::.||...|:.:||||   ..|...:|:|||:..|||..|.||:|.|:..:|...|:.||||.|
Mouse   552 IESSSGTILWKQYLPNV---KPDSSFKLMVQRTTAHFPHPPQCTLLVKDKETGMSSLFVFNPIFG 613

  Fly   534 KVAEGGLVQLDYRIKQLSLLGETEKDFLKGILLLDASNKVHVYP------EHAAPLADGMYLYTA 592
            |.::.....|...|.|..||...::|:.|.:||:|...||..:|      .....||..::.|..
Mouse   614 KWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLVDDEYKVTAFPATRNVLRQLHELAPSIFFYLV 678

  Fly   593 DLKTAELAGYFVKYAGGQLSSTHIWNARLGGHNSEQQIIGVAGKNPIEHVHSQGRVLGDRSVLYK 657
            |.:...|:||.::   ..|::...|...:  ....|:::.|.||...|||||||||:||||||||
Mouse   679 DAEQGRLSGYQLR---KDLTTELSWELTI--PPEVQRVVKVKGKRSSEHVHSQGRVMGDRSVLYK 738

  Fly   658 YINPNLVAFVTQAPDSTH-KSVLNLYLVDVVSGSVVFTMTHRKVRAPLSIVHSENWLAYSYFNEK 721
            .:||||:|.||::.|..| ::.:.::|:|.|:|.::.:...:|.|.|:.:||||||:.|.|:|.|
Mouse   739 SLNPNLLAVVTESTDVHHERTFIGIFLIDGVTGRIIHSSVQKKARGPVHLVHSENWVVYQYWNSK 803

  Fly   722 LRRTEITTIELYEGKSQANSSVWSSLQAPPMPLVERQSYILPTIVEALRETITERGITNKHVLIG 786
            .||.|:|.:|||||..|.|::.:|||..|.:|.|.:||||.|:.:.|:..||||||||::|:|||
Mouse   804 ARRNELTALELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITERGITSRHLLIG 868

  Fly   787 TASGSIVEMPWHLLDPRRPIASTTQGREEGAIPYIPELPLPTESHINYNQTVARLRNIYTAPSGL 851
            ..||:|:.:|..|||||||...|.|.|||..|||.|::.:..|..|||||||:|:|.||||||||
Mouse   869 LPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQVHAERFINYNQTVSRMRGIYTAPSGL 933

  Fly   852 ESTCLVVATGLDLFVTRVAPSKTFDLLKEDFDYILISIVLVALTSGSLIVKHLASRKLLKQAWK 915
            ||||||||.|||::.|||.|||.||:||:|:||:|||.||..|...::|.|.||..|||.:||:
Mouse   934 ESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGLVFATMITKRLAQVKLLNRAWR 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EMC1	NP_649747.1	EMC1_C	709..914	CDD:462261	118/204 (58%)
Emc1	NP_666269.2	PQQ_2	60..>213	CDD:433144	36/171 (21%)
		EMC1_C	791..996	CDD:462261	118/204 (58%)