DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EMC1 and emc-1

DIOPT Version :9

Sequence 1:	NP_001287215.1	Gene:	EMC1 / 40933	FlyBaseID:	FBgn0037530	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_493980.1	Gene:	emc-1 / 173524	WormBaseID:	WBGene00019209	Length:	946	Species:	Caenorhabditis elegans

Alignment Length:	1021	Identity:	315/1021 - (30%)
Similarity:	491/1021 - (48%)	Gaps:	190/1021 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLPALSLALLLGTCSALYEDQIKKFDWRGVNVGALKQSRVD-LNHFQPRILVTTYEGVVASLCVK 69
            ||..:::| :..:.:|::|||..|||||...||...:...| :.....|::|:|.:.|:|||.:.
Worm     3 LLLLVTIA-IFASVTAIFEDQAGKFDWRKQLVGCPAKITFDKVGSKSDRLIVSTAQSVLASLVLN 66

  Fly    70 TGELVWRQVLEQKPRGDVKLLQVSGFADDSSDTAAAPMGSNMGFDM---------LTVQGHAPAL 125
            ||.:.|||::|.                        |.||..|...         ::..|.:
Worm    67 TGNIGWRQIMEN------------------------PSGSTNGLTFTKDREYIYSISEDGRS--- 104

  Fly   126 VRGWNTNMGALEWEWSIMPMNTERAQDAMWIYSKSVLYHV-----LPAWR-------------SH 172
            ||.||.|.|.|..:..|    :|:..:...|:..:...||     |..:|             :.
Worm   105 VRVWNKNNGVLAHQLPI----SEQKSEIQAIHVTNQRLHVASGRTLVVFRLGDEKPVETVISKTE 165

  Fly   173 LEVTAYF--------ASSGHSTGST---SKV-----IAPWITSE-------SCTLSGTFYVCTDG 214
            |..:|:|        .|:..:.|.:   ||:     ..|..|.|       :|.:...:..|:.|
Worm   166 LTFSAFFQQDDVVIHVSALKNAGKSIELSKITEDGAFEPLKTVEIKDFEPKNCHVQEAYLSCSTG 230

  Fly   215 KQLISLDLVSKSGQVIRTSLEAE------------PKGKTQA----LTGLNGVVI---VD---GK 257
            ..|..:|:..:..|.|:  ||.|            .:|...|    :|..||..:   ||   |:
Worm   231 STLQIVDIFRQKVQKIQ--LETEILEISGHGPLILARGAKNAQIVEITAENGAQVRKSVDIGAGE 293

  Fly   258 PISVNKD-QSICGDLRSSSFAVGSFNYRKVLAYADLSSGILRINALYLDNCAPAAELEQSLPFPE 321
            .:.:.:: :|:   :.:||.||     |.|...:.......|:..        |..||.|.|
Worm   294 ALGITENHESV---IVTSSDAV-----RVVFVNSATHFSAKRVKM--------AENLENSAP--- 339

  Fly   322 HFGTPSLSNFDCKQKRNGE----GKNCLFLFSSTSESIVAVQHGRVRWSREESLANVIDSQFVDL 382
                  .|.|..|..::.|    |::|...|.:..::..:|   .:.|||||||...:..:.|||
Worm   340 ------KSIFGRKNDKDWEIVIVGEDCHVEFVTVDQNSKSV---NLEWSREESLITAVSVEMVDL 395

  Fly   383 PLADTEGTLENEMKGKAGDFTSFERDIASAFLRRITTQAVQI-----RSL--------------- 427
            ||::::..:|:|       |...|.:|.|||:|||..|..|:     ||:
Worm   396 PLSESQQMIEDE-------FEDGESNIISAFIRRIQVQFGQLCRQITRSIEKVIYVVTSITKNGN 453

  Fly   428 ----FLHVIGLGPPPTDTQRAGLVRDSFGLHKMLVLLTRAGKIFGIDNVSGKHHWQL----HLPN 484
                |::.:...............||.|.|.|::::.|..|.:||||:..|::.|:|    |...
Worm   454 GVADFINSVRSASGSGSAASGPFERDYFNLRKVIIVATSTGTVFGIDSADGRYLWKLWLGEHFQP 518

  Fly   485 VIGFANDEQMRLIVQRSAKHFPLQPLCTILGKNAVSGNGVLYRFNPITGKVAEGGLVQLDYRIKQ 549
            :....:.|::.|.|||:..|:.|..|.:::..|.::.|||:..|||:.|||....  :|.|.:|:
Worm   519 LESPFDGEKVPLFVQRTTAHYQLDGLASVVFSNKLTHNGVIVSFNPMVGKVVSRN--ELGYPVKR 581

  Fly   550 LSLLGETEKDFLKGILLLDASNKVHVYPEHAAP---LADGMYLYTADLKTAELAGYFVKYAGGQL 611
            ||||.......:..::|:..:.::.::|. ..|   .|...|||..|:::..:.|..:..:..::
Worm   582 LSLLPVHTHKHVYPVMLIGKNEEIKIFPS-ITPEELSATTPYLYLLDIQSQTVQGLKIDISSQKI 645

  Fly   612 SSTHIWNARLGGHNSEQQIIGVAGKNPIEHVHSQGRVLGDRSVLYKYINPNLVAFVTQAPDSTHK 676
              |.:|...| |..::..||.|.||:..:.||||||||..|.|.|||:||||.|..:......|
Worm   646 --TPVWQGNL-GLTAQDDIIAVKGKSFNQKVHSQGRVLVTREVQYKYVNPNLAAIASINRADQH- 706

  Fly   677 SVLNLYLVDVVSGSVVFTMTHRKVRAPLSIVHSENWLAYSYFNEKLRRTEITTIELYEGKSQANS 741
              :.:.|||:|:|.:|.:.:..|...|:.:||||||:||||:::|.||||:..||||||..:.::
Worm   707 --MTITLVDIVTGQIVHSASIGKAAKPIHMVHSENWIAYSYWSDKGRRTELGIIELYEGTEEQHT 769

  Fly   742 --SVWSSLQAPPM-PLVERQSYILPTIVEALRETITERGITNKHVLIGTASGSIVEMPWHLLDPR 803
              .|:.|..|..: |:|.:||||....|:|:..:.||:|:|.:.:|:...||:|.|:...|||..
Worm   770 QKEVFDSKIAEKLPPVVAQQSYIYAQGVDAMSVSETEQGLTTRSILVAHPSGNIHEVSRRLLDAN 834

  Fly   804 RPIASTTQGREEGAIPYIPELPLPTESHINYNQTVARLRNIYTAPSGLESTCLVVATGLDLFVTR 868
            ||:..|...|||..|.|:||:.:.||..|||||||.|:|.|.|:|||||||.||:|.|.|||.||
Worm   835 RPMELTQAMREEMMIGYMPEIAVATEEMINYNQTVHRVRGIKTSPSGLESTSLVLAYGTDLFFTR 899

  Fly   869 VAPSKTFDLLKEDFDYILISIVLVALTSGSLIVKHLASRKLLKQAW 914
            :.||.|||:||:|||::|||:||..|..||.:.|.||....|...|
Worm   900 LVPSGTFDILKDDFDHVLISLVLTGLVVGSYVSKRLARSNALASQW 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC1	NP_001287215.1	DUF1620	709..914	CDD:285069	103/207 (50%)
emc-1	NP_493980.1	WD40	<74..317	CDD:225201	56/283 (20%)
emc-1	NP_493980.1	DUF1620	737..945	CDD:369510	103/207 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158688
Domainoid	1	1.000	196	1.000	Domainoid score	I1830
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9002
Inparanoid	1	1.050	382	1.000	Inparanoid score	I1184
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58306
OrthoDB	1	1.010	-	-		D1017611at2759
OrthoFinder	1	1.000	-	-		FOG0004336
OrthoInspector	1	1.000	-	-		oto18077
orthoMCL	1	0.900	-	-		OOG6_102462
Panther	1	1.100	-	-	LDO	PTHR21573
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R394
SonicParanoid	1	1.000	-	-		X3060
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940