DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wtrw and TRPA1

DIOPT Version :9

Sequence 1:	NP_731193.1	Gene:	wtrw / 40931	FlyBaseID:	FBgn0260005	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	XP_011515926.1	Gene:	TRPA1 / 8989	HGNCID:	497	Length:	1144	Species:	Homo sapiens

Alignment Length:	886	Identity:	215/886 - (24%)
Similarity:	366/886 - (41%)	Gaps:	188/886 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 DLIESLLEAGADLHFCDQNGISALHLSAFSGCLATLGLLVAKGLN----VNLQSKCY-TPLHCAA 223
            ::|:..|:.||.:...::...:|:|.:|..|....:.|:::....    ||....|: |.||.|:
Human   278 EMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRAS 342

  Fly   224 FGNAAEAAKLLINNGADISKDTSKPNCEESLLHCAVRSNALECLQIFIAEGADVNSLKPN-GTNA 287
            ..:..|.|..||:.||||:|..|:   ..|.|..|..|.:...:.:.:::||.|: :|.| |.|.
Human   343 LFDHHELADYLISVGADINKIDSE---GRSPLILATASASWNIVNLLLSKGAQVD-IKDNFGRNF 403

  Fly   288 IHLAAD----LGNI--------QCLEALLNAPNADA---------------------NVRICIRE 319
            :||...    |.|:        |..|.:::..|...                     ||.|..:.
Human   404 LHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKS 468

  Fly   320 KE-STALHLAADEGNVECVDLLLAKGADAKLKNH---RGFTPLHLAARTSSLDCVESLLRNGNAD 380
            |: .:.||.||..|.:.....||...:|.:|.|.   .|.|||||||:......|:.||:.|...
Human   469 KDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF 533

  Fly   381 ANAEDFDHR--TPLHAAV--GKSENAYDIMETLIQWGANVNHKDIYGFTALHLAALDGLVQCVEM 441
            .:    ||.  |.||.|.  |.::....|::|.::.   .:..|..|.||||.||.:|..:.|.:
Human   534 LS----DHNGWTALHHASMGGYTQTMKVILDTNLKC---TDRLDEDGNTALHFAAREGHAKAVAL 591

  Fly   442 LIFHGADVT------------------------TKSKKGTSALNVITRKTPASVAMIRQKLDAA- 481
            |:.|.||:.                        .:||:....|.:.:..:|.:...|.:.::..
Human   592 LLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLP 656

  Fly   482 ---------ITLHHSQDPVNREVELELDFRQLLQHCHPRE--------------ISYLNTFVDEG 523
                     ..||.::|...|:..:|.:|:.|  .| |.|              ::.||..|...
Human   657 ECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYL--QC-PLEFTKKTPTQDVIYEPLTALNAMVQNN 718

  Fly   524 QKEILEHPLCSSFLYIKW---GKIRKYYIGRLIFCFSFVLFLTLYVLTALAHNCYNGSKNDNTTI 585
            :.|:|.||:|..:|.:||   | .|.:.:....:|      |.|..:|.|..|...|...::|.|
Human   719 RIELLNHPVCKEYLLMKWLAYG-FRAHMMNLGSYC------LGLIPMTILVVNIKPGMAFNSTGI 776

  Fly   586 PAQELCQKQSILGDMLRNNPFVMEMQWWVLVAITIVEIFRKLYGITGY--------SSFRHYVTQ 642
             ..|......||.   ..|.:        |:...::.:|  |..|.||        ...|:|...
Human   777 -INETSDHSEILD---TTNSY--------LIKTCMILVF--LSSIFGYCKEAGQIFQQKRNYFMD 827

  Fly   643 VENIMEWFVITS--VFVISYIYTNKTYTFQNHIGAFAVLLGWTNLMLMIGQLPVFDVYVAMYTRV 705
            :.|::||.:.|:  :||:. ::.......|...||.||...|.|.:|.:.:.....:::.|...:
Human   828 ISNVLEWIIYTTGIIFVLP-LFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVI 891

  Fly   706 QGEFAKLFMAYSCMLIGFTISFCVIFPSSSSFANPFMGFITVLVMMIGEQDLSLLINDPEGKDPP 770
            .....:..:.:..:|:.|.:||.::......|::|.:..|....||:|:      ||..|....|
Human   892 LKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGD------INYRESFLEP 950

  Fly   771 FLLEVSAQ--ITF---VLFLLFVTIILMNLLVGIAVHDIQGLKKTAGLSKLVRQTKLISYIESAL 830
            :|....|.  ::|   |.|.:||.|:|||||:|:||.||..::|.|.|.::..|.:|.:.:|..
Human   951 YLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKK- 1014

  Fly   831 FNGYLPTW-LRNLLHYTALVSPQAYR----------VVLCV----KPLNPSEKRLPREILMKAY- 879
                ||.| ||.:...:.:|.|...|          .:.|.    :.:..::|.|..|||.:.|
Human  1015 ----LPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYR 1075

  Fly   880 ------------EVGKMRKHFGHTISSKNSAENYLSYKNKY 908
                        |:.|:.......||.....:::.|:::::
Human  1076 LKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRF 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wtrw	NP_731193.1	Ank_2	156..241	CDD:289560	22/81 (27%)
		ANK repeat	182..213	CDD:293786	7/34 (21%)
		ANK repeat	215..242	CDD:293786	12/27 (44%)
		ANK	216..341	CDD:238125	41/160 (26%)
		ANK repeat	250..281	CDD:293786	7/30 (23%)
		Ank_2	255..351	CDD:289560	30/130 (23%)
		ANK repeat	283..317	CDD:293786	13/67 (19%)
		ANK	323..443	CDD:238125	41/126 (33%)
		ANK repeat	323..351	CDD:293786	9/27 (33%)
		Ank_2	325..420	CDD:289560	31/101 (31%)
		ANK repeat	353..385	CDD:293786	12/31 (39%)
		ANK repeat	387..420	CDD:293786	9/36 (25%)
		Ank_2	392..>460	CDD:289560	22/93 (24%)
		ANK repeat	422..452	CDD:293786	13/53 (25%)
		Ion_trans	613..812	CDD:278921	56/213 (26%)
TRPA1	XP_011515926.1	Ank_4	91..143	CDD:290365
		ANK repeat	92..120	CDD:293786
		ANK	120..243	CDD:238125
		ANK repeat	122..153	CDD:293786
		Ank_2	127..220	CDD:289560
		ANK repeat	155..187	CDD:293786
		ANK repeat	189..214	CDD:293786
		ANK repeat	222..261	CDD:293786
		Ank_4	226..282	CDD:290365	1/3 (33%)
		ANK	258..387	CDD:238125	30/111 (27%)
		ANK repeat	266..294	CDD:293786	4/15 (27%)
		Ank_2	268..364	CDD:289560	25/85 (29%)
		ANK repeat	296..364	CDD:293786	21/67 (31%)
		ANK	361..527	CDD:238125	43/169 (25%)
		ANK repeat	366..397	CDD:293786	7/34 (21%)
		ANK repeat	437..468	CDD:293786	3/30 (10%)
		Ank_2	442..531	CDD:289560	25/88 (28%)
		ANK repeat	470..504	CDD:293786	10/33 (30%)
		ANK	501..625	CDD:238125	36/130 (28%)
		ANK repeat	506..536	CDD:293786	12/33 (36%)
		Ank_2	511..602	CDD:289560	32/97 (33%)
		ANK repeat	538..570	CDD:293786	7/34 (21%)
		ANK repeat	572..597	CDD:293786	11/24 (46%)
		Ion_trans	769..997	CDD:278921	62/248 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D180347at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820