DRSC/TRiP Functional Genomics Resources

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Protein Alignment wtrw and Trpa1

DIOPT Version :9

Sequence 1:NP_731193.1 Gene:wtrw / 40931 FlyBaseID:FBgn0260005 Length:986 Species:Drosophila melanogaster
Sequence 2:NP_808449.1 Gene:Trpa1 / 277328 MGIID:3522699 Length:1125 Species:Mus musculus


Alignment Length:1172 Identity:238/1172 - (20%)
Similarity:431/1172 - (36%) Gaps:389/1172 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 RISLIDQMKSAAGRV--KLFEDI----EQSNVVAEG----IRTHFESASKLEK----NLCYL-WA 157
            ||.|.::.|...|.|  .:.||:    |...|..||    :....::..||.|    |||.| .|
Mouse     7 RILLPEERKEVQGVVYRGVGEDMDCSKESFKVDIEGDMCRLEDFIKNRRKLSKYEDENLCPLHHA 71

  Fly   158 AYLKRWDLIESLLEAGA--DLHFCDQNGISALHLSAFSGCLATLGLLVAKGLNVNLQSK-CYTPL 219
            |...:.:|:|.::...:  .|:..|..|.:.||.:|....:.::..|:::|.|.||::: ..:||
Mouse    72 AAEGQVELMELIINGSSCEVLNIMDGYGNTPLHCAAEKNQVESVKFLLSQGANPNLRNRNMMSPL 136

  Fly   220 HCAAF------------------------GNAA----------EAAKLLINNGADISKD------ 244
            |.|..                        ||.|          ||.::|:..||.:.|.      
Mouse   137 HIAVHGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSEALQILLEKGAKLCKSNKWGDY 201

  Fly   245 -------TSKPNCEE-------------------------SLLHCAVRSNALECLQIFIAEGADV 277
                   :....|.|                         |.||.||:|..|:.:::.:..||.:
Mouse   202 PVHQAAFSGAKKCMELILAYGEKNGYSRETHINFVNHKKASPLHLAVQSGDLDMIKMCLDNGAHI 266

  Fly   278 NSLKPNGTNAIHLAADLGNIQCLEALLNAPNADANVRICIREKESTALH---------------- 326
            :.::.....|:|.||..|....::.::::....:::...:...:.|.||                
Mouse   267 DMMENAKCMALHFAATQGATDIVKLMISSYTGSSDIVNAVDGNQETLLHRASLFDHHDLAEYLIS 331

  Fly   327 -----------------LAADEGNVECVDLLLAKGADAKLKNH---------------------- 352
                             ||....:...|:|||.|||...:|:|                      
Mouse   332 VGADINSTDSEGRSPLILATASASWNIVNLLLCKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPE 396

  Fly   353 ----------------RGFTPLHLAARTSSLDCVESLLRNGNADANAEDFDHRTPLH--AAVGK- 398
                            .|.||||.|.|......|.:|| ..|...:::..|.::|||  |:.|: 
Mouse   397 FMQMQHIKELVMDEDNDGCTPLHYACRQGVPVSVNNLL-GFNVSIHSKSKDKKSPLHFAASYGRI 460

  Fly   399 ------------------------------SENAYD-IMETLIQWGA----------NVNHKDIY 422
                                          ::|.:| :::.|::.||          .::|..:.
Mouse   461 NTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMG 525

  Fly   423 GF-----------------------TALHLAALDGLVQCVEMLIFHGADV--------------- 449
            |:                       ||||.||.:|..:.|.||:.:.||:               
Mouse   526 GYTQTMKVILDTNLKCTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALH 590

  Fly   450 ---------TTKSKKGTSALNVITRKTPASVAMIRQK-----------LDAAITLHHSQDPVNRE 494
                     |.::|:....|.|.|..:|::...|.:.           ||..: :..::|...::
Mouse   591 NKRKEVVLTTIRNKRWDECLQVFTHNSPSNRCPIMEMVEYLPECMKVLLDFCM-IPSTEDKSCQD 654

  Fly   495 VELELDFRQL------------LQHCHPREISYLNTFVDEGQKEILEHPLCSSFLYIKWGK--IR 545
            ..:|.:|:.|            .|......::.||..|...:.|:|.||:|..:|.:||..  .|
Mouse   655 YHIEYNFKYLQCPLSMTKKVAPTQDVVYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFR 719

  Fly   546 KYYIGRLIFCFSFVLFLTLYVLTALAHNCYNGSKNDNTTIPAQELCQKQSILGDMLRNNPFVMEM 610
            .:.:....:|...:. :||.|:.......:|.:...|.|....|    :.|  |.|.:.|..:.|
Mouse   720 AHMMNLGSYCLGLIP-MTLLVVKIQPGMAFNSTGIINGTSSTHE----ERI--DTLNSFPIKICM 777

  Fly   611 QWWVLVAIT--------IVEIFRKLYGITGYSSFRHYVTQVENIMEWFVITS--VFVISYIYTNK 665
               :||.::        :::||::.         |:|.....|.:||.:.|:  :||:. ::.|.
Mouse   778 ---ILVFLSSIFGYCKEVIQIFQQK---------RNYFLDYNNALEWVIYTTSIIFVLP-LFLNI 829

  Fly   666 TYTFQNHIGAFAVLLGWTNLMLMIGQLPVFDVYVAMYTRVQGEFAKLFMAYSCMLIGFTISFCVI 730
            ....|...||.|:...|.|.:|.:.:.....:::.|...:.....:....:..:|:.|.:||.|:
Mouse   830 PAYMQWQCGAIAIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVL 894

  Fly   731 FPSSSSFANPFMGFITVLVMMIGE---QDLSLLINDPEGKDPPFLLEVSAQI-TF---VLFLLFV 788
            .....:|:.|.:..|....||:|:   :|..|        :|.|..|::..: ||   :.|.:||
Mouse   895 LNFQDAFSTPLLSLIQTFSMMLGDINYRDAFL--------EPLFRNELAYPVLTFGQLIAFTMFV 951

  Fly   789 TIILMNLLVGIAVHDIQGLKKTAGLSKLVRQTKLISYIESALFNGYLPTW-LRNLLHYTALVSPQ 852
            .|:|||||:|:||.||..::|.|.|.::..|.:|.:.:|..     ||.| ||.:...:.:|.|.
Mouse   952 PIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKK-----LPLWYLRKVDQRSTIVYPN 1011

  Fly   853 AYRVVLCVKPLNPSEKRLPREILMKAYEVGKMRKHFGHTISSKNSAENYLSYKNKYNNNNGATTG 917
            .                 ||.        |:|.:.|.:.::.:.:.:.                 
Mouse  1012 R-----------------PRH--------GRMLRFFHYFLNMQETRQE----------------- 1034

  Fly   918 YVLPDSDPDAGQFTTLTTKIDDNADRIEFLTQEIQELKQALISQQQQASK-VIDKLLIVISNQQK 981
              :|:.|      |.|..:|.....|::.||        :|:.:|.:..| :|.|:.|:...:.:
Mouse  1035 --VPNID------TCLEMEILKQKYRLKDLT--------SLLEKQHELIKLIIQKMEIISETEDE 1083

  Fly   982 QN 983
            .|
Mouse  1084 DN 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wtrwNP_731193.1 Ank_2 156..241 CDD:289560 27/121 (22%)
ANK repeat 182..213 CDD:293786 9/30 (30%)
ANK repeat 215..242 CDD:293786 12/60 (20%)
ANK 216..341 CDD:238125 36/229 (16%)
ANK repeat 250..281 CDD:293786 11/55 (20%)
Ank_2 255..351 CDD:289560 25/128 (20%)
ANK repeat 283..317 CDD:293786 5/33 (15%)
ANK 323..443 CDD:238125 47/257 (18%)
ANK repeat 323..351 CDD:293786 12/60 (20%)
Ank_2 325..420 CDD:289560 36/209 (17%)
ANK repeat 353..385 CDD:293786 11/31 (35%)
ANK repeat 387..420 CDD:293786 12/76 (16%)
Ank_2 392..>460 CDD:289560 25/158 (16%)
ANK repeat 422..452 CDD:293786 14/76 (18%)
Ion_trans 613..812 CDD:278921 54/215 (25%)
Trpa1NP_808449.1 Ank_2 41..129 CDD:372319 24/87 (28%)
ANK 1 63..94 9/30 (30%)
ANK repeat 67..96 CDD:293786 6/28 (21%)
ANK repeat 98..129 CDD:293786 9/30 (30%)
ANK 2 98..127 7/28 (25%)
Ank_2 101..>373 CDD:393464 49/271 (18%)
ANK repeat 131..163 CDD:293786 4/31 (13%)
ANK 3 131..161 4/29 (14%)
ANK 4 165..194 8/28 (29%)
ANK repeat 165..190 CDD:293786 6/24 (25%)
ANK repeat 198..237 CDD:293786 2/38 (5%)
ANK 5 198..227 2/28 (7%)
ANK 6 239..268 9/28 (32%)
ANK repeat 242..307 CDD:293786 14/64 (22%)
ANK 7 272..301 5/28 (18%)
ANK repeat 309..340 CDD:293786 3/30 (10%)
ANK 8 309..338 3/28 (11%)
ANK repeat 342..373 CDD:293786 9/30 (30%)
ANK 9 342..371 9/28 (32%)
ANK repeat 413..444 CDD:293786 11/31 (35%)
ANK 10 413..442 11/29 (38%)
Ank_2 418..507 CDD:372319 17/89 (19%)
ANK repeat 446..480 CDD:293786 6/33 (18%)
ANK 11 446..475 6/28 (21%)
ANK repeat 482..512 CDD:293786 5/29 (17%)
ANK 12 482..511 5/28 (18%)
Ank_2 487..578 CDD:372319 19/90 (21%)
ANK repeat 514..546 CDD:293786 2/31 (6%)
ANK 13 514..543 2/28 (7%)
ANK 14 548..577 12/28 (43%)
ANK repeat 548..573 CDD:293786 10/24 (42%)
Ion_trans <799..975 CDD:366146 50/193 (26%)
Inositolphosphate binding. /evidence=ECO:0000250|UniProtKB:O75762 1048..1054 1/5 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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