DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wtrw and trpa-1

DIOPT Version :9

Sequence 1:	NP_731193.1	Gene:	wtrw / 40931	FlyBaseID:	FBgn0260005	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	NP_502249.3	Gene:	trpa-1 / 178118	WormBaseID:	WBGene00007801	Length:	1211	Species:	Caenorhabditis elegans

Alignment Length:	1101	Identity:	242/1101 - (21%)
Similarity:	435/1101 - (39%)	Gaps:	254/1101 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EVEQPLTENNANNRFKSIPPNLMVRWRNNTDAMIEAQYPTAGEFEYME-CGPSPPAES--APSMY 88
            |:.|.|.:.|:|...:.        .|.||...|.|   ..||.||:| .....|.|:  |.:::
Worm   221 EIIQELIKANSNVTKRD--------QRLNTVFHIVA---LRGEPEYLEMMMDHDPVEAIKALNLF 274

  Fly    89 DSFEEPTSELSVQICN-DTLRISLIDQMKSAA------------GRVKLFEDIEQSNVVAEGIRT 140
            ::.::....::|:..: :||:..|..:.|::.            ...|.|.::.::.|.|.|.:.
Worm   275 NNEKKTPLRMAVEGNHPETLKKILQMEKKNSCKWMDREKELIHFAAEKGFLEVLKALVEAGGNKN 339

  Fly   141 HFESASKLEKNLCYLWAAYLKRWDLIESLLEAGAD-LHFCDQNGISALHLSAFSGCLATLGLLVA 204
            .......:..::    ||.:.:.:::..|:|...| :...|:.|::.|.::........:..|:|
Worm   340 ELNEVKAVPLHV----AAQMNQLEVVSYLIEEEKDNIDVVDEQGLTPLMMAVTHDSKKCVEYLIA 400

  Fly   205 KGLNVNLQSKC-YTPLHCAAFGNAAEAAKLLINNGADISKDTSKPNCEESLLHCAVRSNALECLQ 268
            |..|:.:..|. .||:...|..||..:.:.::::....:|:|.:         .|::|.....|:
Worm   401 KKANLTITDKDERTPVFIGAKFNALSSVEYILDHLRKKNKETER---------SALKSPTRNTLR 456

  Fly   269 IFIAEGAD---VNSLKPNGTNAIHLAADLGNIQCLEALLNAPNADANVRICIREKESTALHLAAD 330
            | ::|...   ||.:..:....:|:.|..|.::.:: ||....|....   :.|.|.||||.||.
Worm   457 I-VSEDVRRTMVNMVDRDQNTPMHIVASNGYLEMMQ-LLQKHGASITQ---VNEDEETALHRAAI 516

  Fly   331 EGNVECVDLLLAKGADAKL---KNHRGFTPLHLAARTSSLDCVESLLRNGNADANAEDFDHRTPL 392
            .|....|..||.  .|.:|   |:..|.:.|||||| |..|....:|.:..||..|::...:|||
Worm   517 GGQTGAVRQLLE--WDIRLLLMKDEMGNSALHLAAR-SGHDATTKVLLDNGADKEAKNSYQKTPL 578

  Fly   393 HAAV--GKSENAYDIMETLIQWGANV-NHKDIYGFTALHLAALDGLVQCVEMLIFHGADVTTKSK 454
            ..||  ||.|..    :.|:..||.: :..|..  |.||.||..|....|...|..|..:..:.:
Worm   579 QVAVDSGKLETC----QRLVAKGAQIESSSDTK--TVLHTAAFYGNESIVRYFIAEGVTIDRRDE 637

  Fly   455 KGTSALNVITRKTPASVAMIRQKLDA---------AITLHHSQDPVNREVELELDFRQLL----- 505
            :|.:|.::........||....:.|.         .|.|...::|||  ::....||.||
Worm   638 EGKTAFDIACENDHKDVARAFLETDQWKNLMIPCDVIPLDKHRNPVN--MKRRTPFRTLLTKFPE 700

  Fly   506 ------QHC---------HPREISYLNTFVDE------------GQK------------------ 525
                  .:|         ..:.::|...|:|:            |::
Worm   701 LASFVMDNCIEKSKEETDSTQSVAYNFEFLDDTYMMRCVSDDGTGEQLIGCKSAYDEDFKLEKDA 765

  Fly   526 -------------------------EILEHPLCSSFLYIKWGKI-RKYYIGRLIFCFSFVLFLTL 564
                                     .:|.|||..:.|..||.:: |..|...|.....|::.||.
Worm   766 QSYASNYDRVYKYHPLKLMADAEKLHLLNHPLSKALLKYKWNRLGRPMYYFALFMYLVFIVSLTQ 830

  Fly   565 YVL-TALAHNCYN-GSKNDNTTIPAQELCQKQSILGDMLRNNPFVMEMQWWVLVAITIV------ 621
            ||. |...:|.:| .|..|:......|.|.         :.|....::.|.:::....|
Worm   831 YVRHTKAPYNVWNEESYYDSEYFDENETCP---------QINTTKPDVVWKIIIQTLAVCQILVE 886

  Fly   622 --EIFRKLYGITGYSSFRHYVTQVENIMEWFVITSVFVISYIYTNKTYT------FQNHIGAFAV 678
              ::|::.:.         |:...||.::.|:.::..:..|.::..:.|      :|..:.|..:
Worm   887 CFQLFQRKFA---------YLVNWENWIDCFIYSTALITVYDFSECSATSGVRQNWQWILAALCI 942

  Fly   679 LLGWTNLMLMIGQLPVFDVYVAMYTRVQGEFAKLFMAYSCMLIGFTISFCVIFPSSSSFANPFMG 743
            ..||.||:.||.::|.|.::|.|:..:...|.:.|..:...:|.|:.||.||..:...|:..||.
Worm   943 FFGWINLLFMIRKMPRFGIFVVMFVDIVKTFFRFFPVFVLFIIAFSSSFYVILQNRPEFSTIFMS 1007

  Fly   744 FITVLVMMIGEQDLSLLINDPEGKDP-----PFLLEVSAQITFVLFLLFVTIILMNLLVGIAVHD 803
            .:...||||||.:.:.:.:..|....     |....|:..: |..|.:.:||:|||||||:||.|
Worm  1008 PLKTTVMMIGEFEFTGIFHGDETTHAEKMFGPAHTAVACAL-FFFFCIIMTILLMNLLVGLAVDD 1071

  Fly   804 IQGLKKTAGLSKLVRQTKLISYIESALFNGYLPTWLRNLLHYTALVSPQAYRVVLCVKPLNPSEK 868
            |:|:::.|.|.:|..|..|:..||::             ||:   ...:..:...|.....|..|
Worm  1072 IKGVQEKAELKRLAMQVDLVLQIEAS-------------LHF---FIQRTKKYATCRYATFPYGK 1120

  Fly   869 RLPREILMKAYEVG---KMRKHFGHTISSKNSAENYLSYKNKYNNNNGATTGYVLPDSDPD---- 926
                  |.|....|   ..|:.||.::|                             :||:
Worm  1121 ------LHKTGFAGWWSNFRRRFGLSVS-----------------------------TDPEIDEM 1150

  Fly   927 ---AGQFTT-LTTKIDDNADRIEFLTQEIQELKQALISQQQQASKVIDKLLIVISNQQKQN 983
               ..:||: :|.|:.:.|.:::.:.:.|..:.:..:..:...:|:...|.|.|..::|.|
Worm  1151 YEREAEFTSEMTQKLQNQAAKLKNIQENIDVMYEKQVRLEAIIAKLATGLNINIELEEKDN 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wtrw	NP_731193.1	Ank_2	156..241	CDD:289560	18/86 (21%)
		ANK repeat	182..213	CDD:293786	6/30 (20%)
		ANK repeat	215..242	CDD:293786	5/27 (19%)
		ANK	216..341	CDD:238125	30/127 (24%)
		ANK repeat	250..281	CDD:293786	7/33 (21%)
		Ank_2	255..351	CDD:289560	27/101 (27%)
		ANK repeat	283..317	CDD:293786	6/33 (18%)
		ANK	323..443	CDD:238125	45/125 (36%)
		ANK repeat	323..351	CDD:293786	12/30 (40%)
		Ank_2	325..420	CDD:289560	35/100 (35%)
		ANK repeat	353..385	CDD:293786	13/31 (42%)
		ANK repeat	387..420	CDD:293786	11/35 (31%)
		Ank_2	392..>460	CDD:289560	20/70 (29%)
		ANK repeat	422..452	CDD:293786	9/29 (31%)
		Ion_trans	613..812	CDD:278921	56/217 (26%)
trpa-1	NP_502249.3	Ank_4	51..104	CDD:290365
		ANK repeat	51..81	CDD:293786
		ANK	78..227	CDD:238125	2/5 (40%)
		ANK repeat	86..114	CDD:293786
		Ank_2	88..204	CDD:289560
		ANK repeat	116..171	CDD:293786
		ANK	168..298	CDD:238125	21/87 (24%)
		ANK repeat	173..204	CDD:293786
		ANK repeat	206..237	CDD:293786	5/15 (33%)
		Ank_4	208..258	CDD:290365	14/47 (30%)
		Ank_2	244..342	CDD:289560	20/100 (20%)
		ANK repeat	280..310	CDD:293786	5/29 (17%)
		Ank_2	316..409	CDD:289560	17/96 (18%)
		ANK repeat	316..342	CDD:293786	5/25 (20%)
		ANK	339..493	CDD:238125	30/168 (18%)
		ANK repeat	344..376	CDD:293786	5/35 (14%)
		ANK repeat	378..409	CDD:293786	6/30 (20%)
		Ank_2	383..504	CDD:289560	26/134 (19%)
		ANK	468..594	CDD:238125	43/136 (32%)
		ANK repeat	473..504	CDD:293786	6/34 (18%)
		Ank_2	479..571	CDD:289560	34/98 (35%)
		ANK repeat	506..538	CDD:293786	13/33 (39%)
		ANK	536..659	CDD:238125	39/129 (30%)
		ANK repeat	540..571	CDD:293786	13/31 (42%)
		Ank_2	545..636	CDD:289560	33/97 (34%)
		ANK repeat	573..601	CDD:293786	11/31 (35%)
		ANK repeat	605..636	CDD:293786	10/32 (31%)
		Ion_trans	857..1080	CDD:278921	60/241 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24197
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940