Protein Alignment wtrw and LOC1270502

DIOPT Version :10

• Sequence 1: NP_731193.1
• Gene: wtrw / 40931
• FlyBaseID: FBgn0260005
• Length: 986
• Species: Drosophila melanogaster
• Sequence 2: XP_309204.5
• Gene: LOC1270502 / 1270502
• VectorBaseID: AGAMI1_005893
• Length: 1140
• Species: Anopheles gambiae
• Alignment Length: 1124
• Identity: 220/1124 - (19%)
• Similarity: 389/1124 - (34%)
• Gaps: 318/1124 - (28%)

  Fly    14 RRMTRSISVVTKTEVEQPLTENNANNRFKSIPPNL------MVRWRNNTDAMIEAQYPTAGEFEY 72
            :|:...:.::...:..:.:.|..:...:..:.|.|      :.|:|...|..|| ::....|...
Mosquito    62 KRLEELVDLMKLWDAPKTIPEPKSFLHYARLQPVLAQMLEDIARYRTYLDRFIE-RFQAENECIV 125

  Fly    73 MECGPSPPAE----SAPSMYDSFEEPTSELSVQICNDTLRISLIDQMKSAAGRVKLFEDIE---- 129
            .:..|...::    |||..|.:.:.....|...:......|:|.:..|..|..:...|.::
Mosquito   126 PKHNPQNKSDTANPSAPIHYAALQLDEDFLEWLLARSATDINLRNSFKQTALTLLCEEYVQCMRK 190

  Fly   130 QSNVVAEG----IRTHFESASKLEKNLCYLWAAYLKRWDLIESLLEAGADLHFCDQNGISALHLS 190
            |......|    |||                        ::..||:|.||.:.|..      |:.
Mosquito   191 QMQACPPGRLGKIRT------------------------VVLRLLKAKADFNICSS------HMK 225

  Fly   191 -AFSGCLATLGLLVAKGLNVNLQSK-----CYTPLHCA--------------AFGN-------AA 228
             .|.        |:.|....:.:::     |...:.||              .|.|       ..
Mosquito   226 LPFE--------LLLKHCETHDETRLFVEQCVELVPCALAISSVNDRNERVVGFYNNNPNVQVTV 282

  Fly   229 EAAKLLINN-----------GADISKDTSKPNCEESLLHCAVRSNALECLQIFIAEG-------- 274
            |..:|.:.:           |.:|.....| .....|||.|......:|:::.:..|
Mosquito   283 ELLELFLRHNDRSNFTTHLAGFEIDASNVK-KVIRLLLHTACDQKMADCVRLIVDRGERHIFKVL 346

  Fly   275 ---------ADVNSLKPNGTNAIHLAADLG-----NIQC---------LEALLNAPNADANVRIC 316
                     |....:...|.|::.|:...|     ::|.         |:.||.        ::|
Mosquito   347 PRKPGRNAAAKEGPVAEEGANSVELSRRFGWQESIDVQKGSELEHRVELKGLLK--------KVC 403

  Fly   317 IREKESTALHLAADEGNVECVDLLLAKGADAKLKNHRGFTPLHLA----------ARTSSLDCVE 371
                      |.||   :..:.|||||.:|..:.|......:.||          .|.:.|.|.|
Mosquito   404 ----------LMAD---LPLLQLLLAKISDLIVLNDDPLLVVTLAKAYDYKRRVEERNALLACAE 455

  Fly   372 SLLRNGNADANAEDFDHRTPLHAAV--GKSENAYDIMETLIQWGANVNHKDI----YGFTALHLA 430
            .|........:..|....|.||.|:  |....|..::.....:....|:.::    ||..|...:
Mosquito   456 FLATQETIHMSKRDNSGNTSLHLALKYGFDSVALALLRQRYTYLGMRNNDNLTPLDYGTFAFWRS 520

  Fly   431 ALDGLVQCVEM----------LI------FHG---ADVTTKSKKGTSALNVITRKTPASVAMIRQ 476
            .||   ||:|:          :|      ||.   :..:..|..||.|.:..:|...:|..:| |
Mosquito   521 YLD---QCIEVDSKRSIPDRNVIRFNLQGFHSPALSMTSAVSADGTPAASDRSRNKRSSWKLI-Q 581

  Fly   477 KLDAAITLHHSQDPVNREVELELDFRQLLQHCHPREISYLNTFVDEGQKEILEHPLCSSFLYIKW 541
            ::|......|.   ..|.|......||:.|   .:|:           |.:|.||:..:|:.:||
Mosquito   582 RVDQTYCQPHK---FTRTVTEMTTLRQIAQ---SKEL-----------KRLLVHPVVYTFIMVKW 629

  Fly   542 GKIRKYYIGRLIFCFSFVLFLTLYVLTALAHNCYNGSKNDNTTIPAQELCQKQSILGDMLRNNPF 606
            .::..:....|:.....::|...|.|||    |   |....:|:     ....|:||
Mosquito   630 TRLCHWNYLNLLLTALTIIFFGNYSLTA----C---SVEGPSTV-----LWLLSLLG-------- 674

  Fly   607 VMEMQWWVLVAITIVEIFRKLYGITGYSSFRHYVTQVENIMEWFVITSVFVISYIYTNKTYTFQN 671
                    :|.:.|.|..:.|:....|.||       ||..:   :.:...:|.:..|..   ..
Mosquito   675 --------VVCVAIRETLQLLFLRRSYLSF-------ENAQD---LINAVAMSVVLANGC---NG 718

  Fly   672 HIGAFAVLLGWTNLMLMIGQLPVFDVYVAMY--TRVQGEFAKLFMAYSCMLIGFTISFCVIFP-- 732
            .:.:|.|:.....|..::|.|....:...||  ..|...|.|.|:.:..::..|..:|.:.:.
Mosquito   719 LLSSFVVISFAMQLTFLLGSLQSNSLATMMYMFKTVSKNFLKSFLLFMPLIGAFIYAFHLTYNED 783

  Fly   733 -------------SSSSFANPFMGF----ITVLVMMIGEQDLSLLINDPEGKDPPFLLEVSAQIT 780
                         |..:| |.|..|    |..|||..||.:.:.:  |.||         ...:.
Mosquito   784 PEDHAQVCERDDCSEENF-NNFRTFWNATIKTLVMTTGEFEAAAI--DFEG---------GKMLL 836

  Fly   781 FVLFLLFVTIILMNLLVGIAVHDIQGLKKTAGLSKLVRQTKLISYIESALFNGYLPTWLRNLLHY 845
            |:||:.|..|:::||:.|:||.||..:::.:.|..:.::..|:...|..:.|.| |.|||...
Mosquito   837 FILFMFFAPIVILNLINGLAVSDIAAIREESELISISKKVMLLEQYERGVANVY-PGWLRRCF-- 898

  Fly   846 TALVSPQAY------RVVLCVKPLNPSEKRLPREILMKAYEVGKMRKHFGHTISSKNSAENYLSY 904
                 |:.:      |:.:..|.....|..| ||:..||   ||     |....:...|....:.
Mosquito   899 -----PRPFFAEYDCRIHVKTKEYRKIEVHL-RELPTKA---GK-----GTAPVNPGGAAALNNA 949

  Fly   905 KNKYNNNNGATTGYVLPDSDPDAGQFTTLTTKIDDNADRIEFLTQ--------EIQELKQALISQ 961
            |::.:.::..:.  .:|.|...|.|     ..:.....:|.::.|        :::..:.||..:
Mosquito   950 KSRLHGSSQCSV--QIPPSGKPAKQ-----KVVGKPLPKIPWIPQGDSCNFIFDVRVFRLALFMR 1007

  Fly   962 QQQASKVIDKLLIVISNQQ 980
            ..|:  ::|:.|.:|..||
Mosquito  1008 LDQS--IVDEALTIIERQQ 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wtrw	NP_731193.1	ANK repeat	182..213	CDD:293786	4/31 (13%)
		ANKYR	196..482	CDD:440430	73/388 (19%)
		ANK repeat	215..242	CDD:293786	8/58 (14%)
		ANK repeat	250..281	CDD:293786	7/47 (15%)
		ANK repeat	283..317	CDD:293786	8/47 (17%)
		ANK repeat	323..351	CDD:293786	9/27 (33%)
		ANK repeat	353..385	CDD:293786	7/41 (17%)
		ANK repeat	387..420	CDD:293786	7/34 (21%)
		ANK repeat	422..452	CDD:293786	11/48 (23%)
		Ion_trans	613..812	CDD:459842	50/219 (23%)
LOC1270502	XP_309204.5	None