Protein Alignment wtrw and pain

DIOPT Version :10

• Sequence 1: NP_731193.1
• Gene: wtrw / 40931
• FlyBaseID: FBgn0260005
• Length: 986
• Species: Drosophila melanogaster
• Sequence 2: XP_003436057.2
• Gene: pain / 11175956
• VectorBaseID: AGAMI1_004662
• Length: 922
• Species: Anopheles gambiae
• Alignment Length: 1040
• Identity: 213/1040 - (20%)
• Similarity: 362/1040 - (34%)
• Gaps: 327/1040 - (31%)

  Fly    55 NTDAMIEAQYPTAGEFEYMECGPSPPAESAPSMYDSFEEPTSELSVQICNDTLRISLIDQMKSAA 119
            |..|::..:.|...|:         |...|...:||  |..|||.     ...||.:..:.:...
Mosquito    70 NHGAVLSEKNPETSEY---------PIHLAALSFDS--ENLSELL-----SAPRIQVDQKYEDRT 118

  Fly   120 GRVKLFEDIEQSNVVAEGIRTHFESASKLEKNLCYLWAAYLKRWDLIESLLEAGADLHFCDQNGI 184
            ....|||.|:..|                       |...   ::.::.||:..|:::..|:|.:
Mosquito   119 ALYLLFEQIDSDN-----------------------WKHV---FECVKLLLKYDANINATDENNV 157

  Fly   185 SALHLSAFSG-----------CLATLGLLVAKGLNVNLQSKCYTPLHCAAFGNAAEAAKLLINN- 237
            |.:.|...:|           ||        :..:||:..:            ..:|.|.::.|
Mosquito   158 SPIALLVTAGYDDWRKEILEYCL--------QNYSVNVDYR------------RQQARKAIVKNF 202

  Fly   238 -GADI-----------------SKDTS-------KPNCEESLLHCAVRSNALECLQIF------- 270
             |.||                 |..|.       :..|:::..|.....:..|.|.:.
Mosquito   203 PGTDIPIYDMEKVTVDVLRNKLSAGTEDEFLAAYEKYCQQNNGHVPREEDRAELLSVAVYRAKLT 267

  Fly   271 ---------IAEGADVNSLKPN-GTNAIHLAADLGNIQCLEALLNAPNADANVRICIREKESTAL 325
                     ||||....  ||. .:..:....:.||:|.||.||.....||...|
Mosquito   268 AAQKLVEGQIAEGKFTG--KPELFSGLLAKCCNRGNVQMLEWLLQIIPDDAVALI---------- 320

  Fly   326 HLAADEGNVECVDLLLAKGADA-KLKNHRGFTPLHLAARTSSLDCVESLLRNGNADANAEDFDHR 389
                   |.:.:..||.|..|. |.||...:      .|:..:     ||.:...:.:..|....
Mosquito   321 -------NEDPLLSLLVKQIDVYKDKNKCPY------FRSMGI-----LLNDPRLEVDKIDAKKC 367

  Fly   390 TPLHAAVG-KSENAYDIMETLIQWGANVNHKDIYGFTALHLAALDGLVQCVEMLIFHGADVTTKS 453
            |.:|.||. |.::|   .|.|:..||.:..::::|  .|.::.:|..
Mosquito   368 TAMHYAVKYKIDHA---QELLLAKGAYIGGENMFG--DLPISEMDSF------------------ 409

  Fly   454 KKGTSALNVITRKTPASVAMIRQKLDAAITLHHSQDPVNREVELELDFRQLLQHCH------PRE 512
                               ::.:.||:.:| ::.:.|.:.:.|:.:.|...:...|      |.:
Mosquito   410 -------------------LLEKHLDSCVT-NNDRKPGDEDYEVRISFANFIPPAHKPNYAKPEQ 454

  Fly   513 ISYLN-TFVDE-----------GQKEILEHPLCSSFLYIKWGKIRKYYIGRLIFCFSFVLFLTLY 565
            :.:.. .:.||           ..|.:|.||:.||.|.:||.|:..::...|:.|..|.:..|.|
Mosquito   455 VPFNGLPYEDEMRPIVRMAQSSSTKRLLRHPVISSILLLKWLKLICFFYINLVICTIFFVSFTAY 519

  Fly   566 VLTALAHNCYNGSKNDNTTIPAQELCQKQSILGDMLRNNPFVMEMQWWVLVAITIVEIFRKLYGI 630
            |:.     ||  .:.|   .|.:......|..|             |..|||..:::....:
Mosquito   520 VVF-----CY--GRED---APFKLFFYFLSFAG-------------WIYLVARELIQFLLNM--- 558

  Fly   631 TGYSSFRHYVTQVENIME-WFVITSVFVISYIYTNKTYTFQNHIGAFAVLLGWTNLMLMIGQLPV 694
                  |.||..:||.|| ..::.|..|:...:.::|   :....|..:||......|::|.|||
Mosquito   559 ------RVYVRSIENGMEVLLILASGAVLMREFGDET---RRVASACVILLSALEFTLLVGTLPV 614

  Fly   695 FDV--YVAMYTRVQGEFAKLFMAYSCMLIGFTISFCVIFPSSSSFANPFMGFITVLVMMIGEQDL 757
            ..:  ::.|...|...|.|..:.||.:|:.|..||..:|.::.  .|...|..|.        |.
Mosquito   615 LSISTHMVMLKTVSKNFLKCLVLYSIILLAFAFSFYTLFRANG--GNGEAGEATT--------DK 669

  Fly   758 SLLINDPEGKDPPF---------LLEVSAQIT-------------------FVLFLLFVTIILMN 794
            :....|.:|.|..|         |::.:..:|                   |.|||.||:|:|.|
Mosquito   670 TAAGQDGDGDDDQFNQFGEVPLALMKTAVMLTGEFEAANIKFQQSSLSYFVFALFLFFVSIVLFN 734

  Fly   795 LLVGIAVHDIQGLKKTAGLSKLVRQTKLISYIESALFNGYLP--------TWL--RNLLHYTALV 849
            |:.|:||.|...:|..:.:..:.::..||:..|:||... .|        .||  .|.|...:..
Mosquito   735 LMNGLAVSDTTTIKAESEIIGITQKVFLINKYENALKTS-KPIRCITERMAWLFPSNSLQLFSNN 798

  Fly   850 SPQAYRVVLCVKPLNPS-----EKRLPREILMKAYEVGKMRKHFGHTISSKN-SAENYLSYKNKY 908
            .|..|   :.||| |.|     ...:||  ..:..|:|::      .:..|. ..|..|....||
Mosquito   799 QPLKY---IAVKP-NQSNAIMVSSLVPR--YAQDVEMGEL------VVQDKKLEVEGLLERNTKY 851

  Fly   909 ----------NNNNGATTGY---VLPDSDPDAGQFTTLTTKIDDNADRIEFLTQEIQELKQALIS 960
                      ||.:|....|   :|.......|......::::.|.:|:.....|:::|.|.|::
Mosquito   852 GTECCIMPCLNNMDGKIVKYALEILHSRHEHVGSIEYRMSRMEQNIERMAQEQIEMKKLLQTLVT 916

  Fly   961  960
            Mosquito   917  916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wtrw	NP_731193.1	ANK repeat	182..213	CDD:293786	8/41 (20%)
		ANKYR	196..482	CDD:440430	58/330 (18%)
		ANK repeat	215..242	CDD:293786	6/45 (13%)
		ANK repeat	250..281	CDD:293786	8/46 (17%)
		ANK repeat	283..317	CDD:293786	10/34 (29%)
		ANK repeat	323..351	CDD:293786	6/28 (21%)
		ANK repeat	353..385	CDD:293786	3/31 (10%)
		ANK repeat	387..420	CDD:293786	10/33 (30%)
		ANK repeat	422..452	CDD:293786	3/29 (10%)
		Ion_trans	613..812	CDD:459842	57/229 (25%)
pain	XP_003436057.2	None