DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wtrw and ANKRD61

DIOPT Version :9

Sequence 1:	NP_731193.1	Gene:	wtrw / 40931	FlyBaseID:	FBgn0260005	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	NP_001258629.1	Gene:	ANKRD61 / 100310846	HGNCID:	22467	Length:	418	Species:	Homo sapiens

Alignment Length:	449	Identity:	105/449 - (23%)
Similarity:	170/449 - (37%)	Gaps:	122/449 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 MECGPSPPAESAPSMYDS-FEEPTSELSVQICNDTLRISLIDQMKSAAGRVKLFEDIEQSNVVAE 136
            :|.|||....|  .:|:: ..|..:.:.|.:.|..:...:.....||:.|:.|.:..|  :::..
Human    20 LEDGPSAALHS--KLYEAIMREDCTTIEVLLRNHPVNQPITILPNSASNRLLLTQPTE--SIIPI 80

  Fly   137 GIRTHFESASKLEKNLCYLWAAYLKRWDLIESLLEAGADLHFCDQNGISALHLSAFSGCLATLGL 201
            .:...:..|..|   ||               ||..|||....|..|            |.||.|
Human    81 HLAAKYHKAQSL---LC---------------LLRHGADPEVRDTTG------------LTTLNL 115

  Fly   202 LVAKGLNVNLQSKCYTPLHCAAFGNAAEAAKLLINNGADISKDTSKPNCEESLLHCAVRSNALEC 266
            ::               ||...                 .|...:||......:...::::::.|
Human   116 ML---------------LHWPV-----------------TSTTWAKPGNRTHRILTDIQNSSITC 148

  Fly   267 LQIFIAEGADVNSLK--PNGTNAIHLAADLGNIQCLEALLNAPNADANVRICIREKESTALHLAA 329
            |:|..|.||.||:..  .|..:.:|||...|....| ::|....||.|   .|.|...|.||:||
Human   149 LRILCAHGAQVNTQGEISNKRSPLHLAIAYGCYPVL-SILTQNGADVN---AINEASMTPLHMAA 209

  Fly   330 DEGNVECVDLLLAKGADAKLK-NHRGFTPLHLAARTSS----------LDCVESLLRNGNADANA 383
            :..|.|.::.|:|.||:.... :..|.|||.||..|:|          :.|:..||.:| |..||
Human   210 NMLNKEMMETLIAYGANVNCAVSSTGNTPLKLAVCTASSKAGRLLGAGVSCIRLLLTHG-AKVNA 273

  Fly   384 EDFDHRTPLHAAVGKSENAYDIMETLIQWGANVN------HKDIYGF---------TALHLAALD 433
            :|:..:|.:|.|......|  |:..|:::.||||      ...||.:         |||
Human   274 QDYKGQTAIHEACFGGREA--IINLLLEFEANVNILTRNGESPIYMYLQRSCNVRDTAL------ 330

  Fly   434 GLVQCVEMLIFHGADVTTKSKKGTSALNVITRKTPASVAMIRQKLDAAITLHHSQDPVN 492
                 :..|::|...:...:.:|.         .||.:.:...:|.....:..||.|::
Human   331 -----LARLLYHTYPLRMTNNQGI---------LPAGIMLPEFRLLRDTLIKQSQKPLS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wtrw	NP_731193.1	Ank_2	156..241	CDD:289560	13/84 (15%)
		ANK repeat	182..213	CDD:293786	5/30 (17%)
		ANK repeat	215..242	CDD:293786	2/26 (8%)
		ANK	216..341	CDD:238125	32/126 (25%)
		ANK repeat	250..281	CDD:293786	8/30 (27%)
		Ank_2	255..351	CDD:289560	31/98 (32%)
		ANK repeat	283..317	CDD:293786	10/33 (30%)
		ANK	323..443	CDD:238125	42/145 (29%)
		ANK repeat	323..351	CDD:293786	11/28 (39%)
		Ank_2	325..420	CDD:289560	36/111 (32%)
		ANK repeat	353..385	CDD:293786	15/41 (37%)
		ANK repeat	387..420	CDD:293786	10/38 (26%)
		Ank_2	392..>460	CDD:289560	17/82 (21%)
		ANK repeat	422..452	CDD:293786	6/38 (16%)
		Ion_trans	613..812	CDD:278921
ANKRD61	NP_001258629.1	ANK 1	27..57		5/31 (16%)
		ANK	<32..115	CDD:295348	23/114 (20%)
		ANK 2	75..104		10/48 (21%)
		ANK	79..221	CDD:238125	47/207 (23%)
		ANK repeat	79..106	CDD:293786	9/44 (20%)
		Ank_2	80..198	CDD:289560	38/183 (21%)
		ANK repeat	108..163	CDD:293786	18/98 (18%)
		ANK 3	132..161		7/28 (25%)
		ANK	166..298	CDD:238125	44/138 (32%)
		ANK 4	167..196		10/32 (31%)
		ANK repeat	169..198	CDD:293786	9/32 (28%)
		Ank_2	172..275	CDD:289560	37/107 (35%)
		ANK repeat	200..232	CDD:293786	11/31 (35%)
		ANK 5	200..229		11/28 (39%)
		ANK repeat	234..275	CDD:293786	15/41 (37%)
		ANK 6	234..273		13/39 (33%)
		Ank_5	263..317	CDD:290568	18/56 (32%)
		ANK	272..>351	CDD:238125	21/100 (21%)
		ANK repeat	277..308	CDD:293786	10/32 (31%)
		ANK 7	277..306		9/30 (30%)
		ANK 8	310..343		7/43 (16%)
		ANK repeat	319..345	CDD:293786	5/36 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144788
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24197
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030