DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArgRS-m and MSR1

DIOPT Version :9

Sequence 1:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_011959.1	Gene:	MSR1 / 856491	SGDID:	S000001133	Length:	643	Species:	Saccharomyces cerevisiae

Alignment Length:	526	Identity:	193/526 - (36%)
Similarity:	299/526 - (56%)	Gaps:	50/526 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GRSAAKIEFQLQPQVFVEQ--LLQT--KEIALHPSPFA---AEH---IVVEYSSPNIAKPFHVGH 154
            |:..||..|.   |.|::|  |:|:  ..|.|....:.   :.|   :|||:||||||||||.||
Yeast   137 GKVCAKGPFL---QFFLDQRYLIQSTVPNILLQKGKYGQKKSRHQKKVVVEFSSPNIAKPFHAGH 198

  Fly   155 LRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGVQLLNVSDKEMQLSPIETLYKSYVA 219
            |||||||..|:||:|.:|:..||:|||||||.|||||.:|.:... .:|.:|..||:.|:..||.
Yeast   199 LRSTIIGGFLSNLYEAMGWSVTRMNYLGDWGRQFGLLAVGFKRYG-DEKTLQKQPIQHLFDVYVK 262

  Fly   220 ANK--AAEQ-----RPEIAQQARDLFAALEGGTDKSMAKKWQQYRNYTIEDLSKVYNRLGVHFDS 277
            .|.  |.|:     :..|:.:||..|..||.| |::..|.|.::|:.:|....:.|:||.::||.
Yeast   263 INMDLAKEEINGNSKCGISGEARSFFKNLENG-DENAIKIWNRFRSLSIHHYIQTYSRLNINFDI 326

  Fly   278 YEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREIVVVD--------GRRIPVIKSNGSTLYLARD 334
            :..|||.|::.:.:.||..|...|:: |.||  .:|:|        | |:.|.||:|:||||.||
Yeast   327 FSGESQVSKESMNEALDIFRKNNLVK-EIDG--ALVIDLTQWSKRLG-RVVVQKSDGTTLYLTRD 387

  Fly   335 IAALLERLSRFQFSRLLYVVDNGQADHFNALFKTTAALDDRLSLEQLQHVKFGRIYGMSTRQGKA 399
            :.|.:||.....|.:::||:.:.|..:.:..|.....::...: :.|||:.||.:.|||||:|..
Yeast   388 VGAAIERKKNLHFDKMVYVISSQQDLYMSQFFMILKKMNFEWA-KDLQHINFGMVQGMSTRKGNV 451

  Fly   400 IFLKDVLDEARD----IM-REKRNISATTRENYNLDDEHVCDILGVSAVLVNVLKQRRQRDHEFS 459
            :||..:||||||    || ..|..||...      :.:.|.|::||||:::..:|.:|..::||:
Yeast   452 VFLDTILDEARDKALQIMENNKMKISQVD------NPQRVADLIGVSAIIIQDMKSKRINNYEFN 510

  Fly   460 WQQALQVNGDTGIKLQYTHCRLHSLLDNFRDVDLDD-IKPDWKHFSTEPADALDLLYALARFDQS 523
            |.:.|...||||..|||||.||.||.....|...|. |..|:.:.: || ..::|:..||::...
Yeast   511 WNRMLSFEGDTGPYLQYTHSRLRSLERTSSDFTTDMLIHADFSNLN-EP-QLVELVRLLAQYPDV 573

  Fly   524 VWQSKEQLEACVLVNYLFGLCNATSQALKRLPVKQESSLEKQLQRLLLFHAAKKTLRHGMELLGL 588
            :.::.|..|...:|.|||.:|:..|...|::.|..:.: :..:.||.::.|:::.|.:.|.||||
Yeast   574 LRRAFETQEPATIVTYLFKVCHQVSSCYKKIWVSGKPA-DIAIPRLAVYSASRQVLHNAMSLLGL 637

  Fly   589 RPLNQM 594
            .|:::|
Yeast   638 VPVDRM 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	192/524 (37%)
		nt_trans	137..397	CDD:294020	112/274 (41%)
		Anticodon_Ia_like	436..594	CDD:299868	53/158 (34%)
MSR1	NP_011959.1	argS	69..643	CDD:273085	192/524 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343009
Domainoid	1	1.000	232	1.000	Domainoid score	I403
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I529
Isobase	1	0.950	-	0	Normalized mean entropy	S1330
OMA	1	1.010	-	-		QHG60659
OrthoFinder	1	1.000	-	-		FOG0004604
OrthoInspector	1	1.000	-	-		otm46946
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	1	1.100	-	-	O	PTHR11956
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	1	1.000	-	-		X3222
TreeFam	1	0.960	-	-
	15	14.740