DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS-m and RARS1

DIOPT Version :9

Sequence 1:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_002878.2	Gene:	RARS1 / 5917	HGNCID:	9870	Length:	660	Species:	Homo sapiens

Alignment Length:	693	Identity:	177/693 - (25%)
Similarity:	295/693 - (42%)	Gaps:	152/693 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CNA--------LKELTERMIRLRQAIC-------EQLPHLKNACYALEVPVKKQQLQNSR-RPTV 62
            |:|        :|.||..:.||:...|       |||.. :|......:.:.::.||..| :||.
Human     8 CSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQE-ENLKLKYRLNILRKSLQAERNKPTK 71

  Fly    63 EWI-----LPSAFAQQEVELLDSLKKRRFEAY--VENVRIVPSAGRSAAKIEFQLQPQVFVEQLL 120
            ..|     |...|..       ::|    .||  :||..::.:..:.|...::|....:.:.|:|
Human    72 NMINIISRLQEVFGH-------AIK----AAYPDLENPPLLVTPSQQAKFGDYQCNSAMGISQML 125

  Fly   121 QTKEIALHP---------------------------------SPFAAEH---------------- 136
            :|||..::|                                 ..|.:|.
Human   126 KTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPALGE 190

  Fly   137 ---IVVEYSSPNIAKPFHVGHLRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGVQ-- 196
               ::|::|||||||..|||||||||||..::.|.|..||...|||::||||||||:|:..:|
Human   191 NKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDK 255

  Fly   197 ---LLNVSDKEMQLSPIETLYKSYVAANKAAEQRPEIAQQARDLFAALEGGTDKSMAKKWQQYRN 258
               .|.||      .||..|...|..:.|..:...|..::|......|: |.:..:.|.|:...:
Human   256 FPDYLTVS------PPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQ-GKNPDITKAWKLICD 313

  Fly   259 YTIEDLSKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREIVVVDGRRIP--V 321
            .:.::|:|:|:.|.|..  .|....:.|.::.|::.:....|.:|.: |||:||.|.|..||  :
Human   314 VSRQELNKIYDALDVSL--IERGESFYQDRMNDIVKEFEDRGFVQVD-DGRKIVFVPGCSIPLTI 375

  Fly   322 IKSNGSTLYLARDIAALLERLSRFQFSRLLYVVDNGQADHFNALFKTTAAL---DDRLSLEQLQH 383
            :||:|...|...|:||:.:||...:...::|||||||:.||..:|.....:   |.:::  ::.|
Human   376 VKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVT--RVFH 438

  Fly   384 VKFGRIYG-----MSTRQGKAIFLKDVLDE----ARDIMREKRNISATTRENYNLDDEHVCDILG 439
            ..||.:.|     ..||.|:.:.|.|:|.|    :.|.::||......|.|..|.....|    .
Human   439 AGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSV----A 499

  Fly   440 VSAVLVNVLKQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSLLDNFRDVD------------ 492
            ...:....|...|..|:.||:.:.|...|:|...|.|...|:.|:. ...::|
Human   500 YGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIA-RLANIDEEMLQKAARETK 563

  Fly   493 -LDDIKPDWKHFSTEPADALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNATSQALKRLPV 556
             |.|.:.:||           |...:.||.:.:.:..:.|....|.:|::.|..|.::.......
Human   564 ILLDHEKEWK-----------LGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYC 617

  Fly   557 KQESS-----LEKQLQRLLLFHAAKKTLRHGMELLGLRPLNQM 594
            .::..     |:..:.|:||..|....:..|.::||::|:.:|
Human   618 VEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	157/617 (25%)
		nt_trans	137..397	CDD:294020	95/274 (35%)
		Anticodon_Ia_like	436..594	CDD:299868	34/175 (19%)
RARS1	NP_002878.2	Could be involved in the assembly of the multisynthetase complex	1..72		17/64 (27%)
		tRNA-synt_1d	80..660	CDD:332079	158/618 (26%)
		L-arginine binding. /evidence=ECO:0000269\|PubMed:24859084, ECO:0007744\|PDB:4Q2T	200..202		1/1 (100%)
		'HIGH' region	201..212		8/10 (80%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q05506	529..543		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.730