Protein Alignment ArgRS-m and RARS2

DIOPT Version :9

• Sequence 1: NP_001262351.1
• Gene: ArgRS-m / 40929
• FlyBaseID: FBgn0037526
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_001337434.1
• Gene: RARS2 / 57038
• HGNCID: 21406
• Length: 588
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 212/602 - (35%)
• Similarity: 329/602 - (54%)
• Gaps: 70/602 - (11%)

  Fly    28 RQAICEQLPHLKN---------------------ACYALEVPVKKQQLQNSRRPTVEWILPSAFA 71
            |:||..||..:.|                     |.:.|.|....::..:..||.:
Human     6 RRAIACQLSRVLNLPPENLITSISAVPISQKEEVADFQLSVDSLLEKDNDHSRPDI--------- 61

  Fly    72 QQEVELLDSLKKRRFEAYVENVRIVPSAGRSAA--KIEFQLQPQVFVEQLLQT-KEIALHPSPFA 133
              :|:.....:|.|.:..|..:    |.|:...  ||..:|..:..::|:::. .:..|....|:
Human    62 --QVQAKRLAEKLRCDTVVSEI----STGQRTVNFKINRELLTKTVLQQVIEDGSKYGLKSELFS 120

  Fly   134 A---EHIVVEYSSPNIAKPFHVGHLRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGV 195
            .   :.||||:||||:||.|||||||||||||.:|||.|.||::..|:|||||||.|||||..|.
Human   121 GLPQKKIVVEFSSPNVAKKFHVGHLRSTIIGNFIANLKEALGHQVIRINYLGDWGMQFGLLGTGF 185

  Fly   196 QLLNVSDKEMQLSPIETLYKSYVAANKAAEQRPEIAQQARDLFAALEGGTDKSMAKKWQQYRNYT 260
            ||....:| :|.:|::.|::.||..||.|.....:|:.|::.|..||.| |......||::|:.:
Human   186 QLFGYEEK-LQSNPLQHLFEVYVQVNKEAADDKSVAKAAQEFFQRLELG-DVQALSLWQKFRDLS 248

  Fly   261 IEDLSKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREIVVVDGRRIP----- 320
            ||:..:||.||||:||.|..||.| :::.|:||..|.|.|||.....|..:|.:.|...|
Human   249 IEEYIRVYKRLGVYFDEYSGESFY-REKSQEVLKLLESKGLLLKTIKGTAVVDLSGNGDPSSICT 312

  Fly   321 VIKSNGSTLYLARDIAALLERLSRFQFSRLLYVVDNGQADHFNALFKTTAALDDRLSLEQLQHVK 385
            |::|:|::||..||:||.::|:.::.|..::||.|.||..||..:|:....:....: |:.|||.
Human   313 VMRSDGTSLYATRDLAAAIDRMDKYNFDTMIYVTDKGQKKHFQQVFQMLKIMGYDWA-ERCQHVP 376

  Fly   386 FGRIYGMSTRQGKAIFLKDVLDEARDIMREKRNISA--TTRENYNLDDEHVCDILGVSAVLVNVL 448
            ||.:.||.||:|...||:|||:|.:  :|..:|:::  ||:|..|  .:...:.:|::|:::...
Human   377 FGVVQGMKTRRGDVTFLEDVLNEIQ--LRMLQNMASIKTTKELKN--PQETAERVGLAALIIQDF 437

  Fly   449 KQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSLLDNFRDVDLDDIKPDWKHFST----EPAD 509
            |.....|::|||.:..|..||||:.|||||.|||||.:.|....|:|       |:|    || .
Human   438 KGLLLSDYKFSWDRVFQSRGDTGVFLQYTHARLHSLEETFGCGYLND-------FNTACLQEP-Q 494

  Fly   510 ALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNATSQALKRLPVKQESSLEKQLQRLLLFHA 574
            ::.:|..|.|||:.:::|.:..:...:|:||..|.:..:.|.|.|.:| :|..|....||.||.|
Human   495 SVSILQHLLRFDEVLYKSSQDFQPRHIVSYLLTLSHLAAVAHKTLQIK-DSPPEVAGARLHLFKA 558

  Fly   575 AKKTLRHGMELLGLRPL 591
            .:..|.:||:|||:.|:
Human   559 VRSVLANGMKLLGITPM 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	201/542 (37%)
		nt_trans	137..397	CDD:294020	119/264 (45%)
		Anticodon_Ia_like	436..594	CDD:299868	57/160 (36%)
RARS2	NP_001337434.1	tRNA-synt_1d	36..576	CDD:332079	206/572 (36%)
		'HIGH' region	133..144		8/10 (80%)
		L-arginine binding. /evidence=ECO:0000250|UniProtKB:P54136	133..135		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144328
Domainoid	1	1.000	248	1.000	Domainoid score	I2149
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5707
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2551
Isobase	1	0.950	-	0	Normalized mean entropy	S1330
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	1	1.000	-	-		FOG0004604
OrthoInspector	1	1.000	-	-		oto91508
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	1	1.100	-	-	LDO	PTHR11956
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	1	1.000	-	-		X3222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750