DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArgRS-m and rars1

DIOPT Version :9

Sequence 1:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_989403.1	Gene:	rars1 / 395040	XenbaseID:	XB-GENE-955966	Length:	660	Species:	Xenopus tropicalis

Alignment Length:	675	Identity:	165/675 - (24%)
Similarity:	292/675 - (43%)	Gaps:	131/675 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLRQ------AICEQLPHLKNACYALEVP------------------VKKQQLQNSRRPT----- 61
            ||||      ::..::..|||..:..|.|                  ::|..|:..::.:
Frog    11 RLRQQETEIKSLAAEIERLKNCGFVSETPSLEGLREENAKLKYRLNILRKSLLEEKKKSSKSMIN 75

  Fly    62 ----VEWILPSAFAQQEVELLDS------LKKRRFEAYVEN-----VRIVPSAGR--SAAKIEFQ 109
                ::.|..:|......||.::      .::.:|..|..|     .:::.:..:  |..:|..:
Frog    76 INAQIQEIFGTAIGAAYPELQNAPLAVTPSQQPKFGDYQCNSAMAITQMLKAMNQKVSPREIADK 140

  Fly   110 LQPQVFVEQLLQTKEIA--------LH------------------PSPFAAEHIVVEYSSPNIAK 148
            :...:...:|::..:||        ||                  |..:..:.:||::|||||||
Frog   141 IVKNIPTNELVEKVDIAGPGFINVHLHKDFTSKQISKLLVNGVQPPVIWERKKVVVDFSSPNIAK 205

  Fly   149 PFHVGHLRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGVQ-----LLNVSDKEMQLS 208
            ..||||||||:||:.:..|.|.:|:...|||:|||||||||:|:..:|     .|.||      .
Frog   206 EMHVGHLRSTVIGDSICRLFEFVGHDVLRLNHLGDWGTQFGMLIAHLQDKFPDYLTVS------P 264

  Fly   209 PIETLYKSYVAANKAAEQRPEIAQQARDLFAALEGGTDKSMAKKWQQYRNYTIEDLSKVYNRLGV 273
            ||..|...|..:.|..::..|..::|......|:..| .:..:.|....:.:.::..|:|:.|.:
Frog   265 PIGDLQSFYKESKKRFDEDEEFKKRAYQCVVQLQNKT-PNFIQAWNLICDVSRKEFQKIYDCLDI 328

  Fly   274 HFDSYEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREIVVVDGRRIP--VIKSNGSTLYLARDIA 336
            .... ..||.|..:.| .|:.:....||:|.: :||::|...|..:|  ::||:|...|...|:|
Frog   329 SIID-RGESFYQDRMI-GVVKEFEEKGLVQVD-EGRKVVFPPGCSVPLTIVKSDGGFTYDTSDLA 390

  Fly   337 ALLERLSRFQFSRLLYVVDNGQADHFNALFKTTAAL---DDRLSLEQLQHVKFGRIYG-----MS 393
            ||.:||...:...::||:|:|||.|...:|.....:   |.:::  :::|..||.:.|     ..
Frog   391 ALKQRLQEEKADMIIYVIDSGQAIHMQNVFSAGRMIGWYDPKVT--RIEHAGFGVVLGEDKKKFK 453

  Fly   394 TRQGKAIFLKDVLDEARDIMREKRNISATTRENYNLDDEHVCDILGVSAVLVNV--LKQRRQRDH 456
            ||.|..:.|.|:|||.  :.|....:....|:.....:|.:.....|:...:..  |...|..|:
Frog   454 TRSGDTVRLIDLLDEG--LKRSMEKLKDKGRDKVLTAEELLAAQTSVAFGCIKYADLSHNRMNDY 516

  Fly   457 EFSWQQALQVNGDTGIKLQYTHCRLHSL--LDNFRDVDLD----------DIKPDWKHFSTEPAD 509
            .||:.:.|...|:|...|.|.:.|:.|:  |.|..|.||.          :.:.:||
Frog   517 IFSFDKMLDDRGNTAAYLLYAYTRIRSIARLANISDEDLHKAAKETEIILEHEKEWK-------- 573

  Fly   510 ALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNATSQALKRL----PVKQESSLEK-QLQRL 569
               |...:.||.:.:.:..:.|....|.:||:.|....::.....    ..:|...:.| .:.||
Frog   574 ---LSKCILRFPEILQKILDDLLLHTLCDYLYELATTFTEFYDNCYCVEKDRQTGQIVKVNMSRL 635

  Fly   570 LLFHAAKKTLRHGMELLGLRPLNQM 594
            ||..|....:..|.::||::|:.:|
Frog   636 LLCDATAAVMAKGFDILGIKPVQKM 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	152/599 (25%)
		nt_trans	137..397	CDD:294020	90/274 (33%)
		Anticodon_Ia_like	436..594	CDD:299868	39/176 (22%)
rars1	NP_989403.1	Could be involved in the assembly of the multisynthetase complex. /evidence=ECO:0000250	1..72		11/60 (18%)
		Syntaphilin	<9..>79	CDD:373718	11/67 (16%)
		PLN02286	79..660	CDD:215160	153/605 (25%)
		L-arginine binding. /evidence=ECO:0000250\|UniProtKB:P54136	200..202		1/1 (100%)
		'HIGH' region	201..212		8/10 (80%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q05506	529..543		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960