DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS-m and Rars2

DIOPT Version :9

Sequence 1:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001100113.1	Gene:	Rars2 / 297969	RGDID:	1305419	Length:	578	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	203/567 - (35%)
Similarity:	320/567 - (56%)	Gaps:	38/567 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VPVKKQQLQNSRRPTVEWILPSAFAQQEVELLDSLKKRRFEAYVENVRIVPSAGRSAAKIEFQLQ 111
            |||.|::.....:.:|:.:|.:...:.:::..|..::...:...:.|....|||  ...:.|::.
  Rat    31 VPVSKKEEVADFQLSVDSLLENNSHKSQLDTQDQAQRLAEKLKCDTVVTAISAG--PRTLNFKIN 93

  Fly   112 PQVFVEQLLQ--TKEIALHP------SPFAAEHIVVEYSSPNIAKPFHVGHLRSTIIGNVLANLH 168
            ..:..:.:||  |::.:.:.      |....:.||||:|||||||.|||||||||||||.:|||.
  Rat    94 RALLTKAVLQQVTEDGSKYGLKSELFSDLPQKRIVVEFSSPNIAKKFHVGHLRSTIIGNFIANLK 158

  Fly   169 EHLGYRTTRLNYLGDWGTQFGLLVLGVQLLNVSDKEMQLSPIETLYKSYVAANKAAEQRPEIAQQ 233
            |.||::.||:||:||||.|||||..|.||....:| :|.:|::.|:..||..||.|.....:.:.
  Rat   159 EALGHQVTRINYIGDWGMQFGLLGTGFQLFGYEEK-LQANPLQHLFDVYVQVNKEATDDKNVTKL 222

  Fly   234 ARDLFAALEGGTDKSMAKKWQQYRNYTIEDLSKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRS 298
            |.:.|..||.|..:::| .||::|:.:||:.:::|.|||::||.|..||.| :::.||||..|.|
  Rat   223 AHEFFHRLELGDTQALA-LWQRFRDLSIEEYTQIYKRLGIYFDEYSGESFY-REKSQDVLKLLDS 285

  Fly   299 AGLLQPEHDGREIVVVD-------GRRIPVIKSNGSTLYLARDIAALLERLSRFQFSRLLYVVDN 356
            .||||....|.  ||||       .....|::|:|::||..||:||.:.|..::.|..::||.|.
  Rat   286 KGLLQKTAKGN--VVVDVSETGDLSSVCTVMRSDGTSLYATRDLAAAIHRKDKYNFDTMIYVADK 348

  Fly   357 GQADHFNALFKTTAALDDRLSLEQLQHVKFGRIYGMSTRQGKAIFLKDVLDEARDIMREKRNISA 421
            ||..||..:|:....:....: |:.|||.||.:.||.||:|:..||:|||:|.:..|.:......
  Rat   349 GQKRHFQQVFQMLKIMGHEWA-ERCQHVPFGIVKGMKTRRGEVTFLEDVLNEVQSRMLQNMASIK 412

  Fly   422 TTRENYNLDDEHVCDILGVSAVLVNVLKQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSLLD 486
            ||::..|  .....:.:|::|:::...:.....|::|||.:..|..||||:.|||||.||.||.:
  Rat   413 TTKKMEN--PRETAEKVGLAALIIQDFRGLLLSDYQFSWDRVFQSRGDTGVFLQYTHARLCSLEE 475

  Fly   487 NFRDVDLDDIKPDWKHFST----EPADALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNAT 547
            .|....|:|       |:.    || .::.:|..|.|||:.::.:.:.|:...:|:||..|.:..
  Rat   476 TFGCGYLND-------FNVACLQEP-QSVSILQHLLRFDEVLYTASQDLQPKHIVSYLLTLSHLA 532

  Fly   548 SQALKRLPVKQESSLEKQLQRLLLFHAAKKTLRHGMELLGLRPLNQM 594
            :.|.|.|.|| :|..|....||.||.|.:..|.:||:|||:.|:.:|
  Rat   533 AVAHKTLQVK-DSPPEVAGARLHLFKAVRSVLANGMKLLGITPVCKM 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	196/545 (36%)
		nt_trans	137..397	CDD:294020	120/266 (45%)
		Anticodon_Ia_like	436..594	CDD:299868	55/161 (34%)
Rars2	NP_001100113.1	ArgS	30..578	CDD:223097	202/565 (36%)
		ArgRS_core	126..388	CDD:185675	120/267 (45%)
		Anticodon_Ia_like	425..578	CDD:299868	55/161 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338048
Domainoid	1	1.000	247	1.000	Domainoid score	I2088
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5707
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2490
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	1	1.000	-	-		FOG0004604
OrthoInspector	1	1.000	-	-		oto98585
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	1	1.100	-	-	LDO	PTHR11956
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770