DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS-m and Rars1

DIOPT Version :9

Sequence 1:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001099247.2	Gene:	Rars1 / 287191	RGDID:	1309215	Length:	660	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	177/686 - (25%)
Similarity:	295/686 - (43%)	Gaps:	138/686 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CNA--------LKELTERMIRLRQ-AICEQLPHL-----KNACYALEVPVKKQQLQNSR-RPTVE 63
            |:|        :|.||..:.||:. :..|..|.|     :|......:.:.::.||..| |||..
  Rat     8 CSARLLQQEKEIKSLTAEIDRLKNCSYLEASPSLEQLREENLKLKYRLNILRRSLQAERKRPTKN 72

  Fly    64 WILPSAFAQQEVELLDSLKKRRFEAY--VENVRIVPSAGRSAAKIEFQLQPQVFVEQLLQTKEIA 126
            .|..::..|   ||.....|   .||  :||..:|.:..:.....::|....:.:.|:|:.||..
  Rat    73 MININSRLQ---ELFGCAIK---AAYPDLENPPLVVTPSQQPKFGDYQCNSAMGISQMLKAKEQK 131

  Fly   127 LHPSPFAA----------------------------------------------------EHIVV 139
            :.|...|.                                                    |.::|
  Rat   132 VSPREIAENITKHLPNNEYIDRVEIAGPGFINVHLRKDFVSEQLTNLLVNGVQLPVLGENEKVIV 196

  Fly   140 EYSSPNIAKPFHVGHLRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGVQ-----LLN 199
            ::|||||||..|||||||||||..::.|.|..||...|||::||||||||:|:..:|     .|.
  Rat   197 DFSSPNIAKEMHVGHLRSTIIGESMSRLFEFAGYNVLRLNHVGDWGTQFGMLIAHLQDKFPDYLT 261

  Fly   200 VSDKEMQLSPIETLYKSYVAANKAAEQRPEIAQQARDLFAALEGGTDKSMAKKWQQYRNYTIEDL 264
            ||      .||..|...|..:.|..:...|..::|.:....|: ..:..:.|.|....:.:.|:.
  Rat   262 VS------PPIGDLQAFYKESKKRFDTEEEFKKRAYECVVLLQ-SKNPDIMKAWNLICDVSREEF 319

  Fly   265 SKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREIVVVDGRRIP--VIKSNGS 327
            :|:|:.|.:..  .|....:.|.:::|::.:....|.:|.: |||:||.|.|..:|  ::||:|.
  Rat   320 NKIYDALDITL--IERGESFYQDRMKDIVKEFEDKGFVQVD-DGRKIVFVPGCSVPLTIVKSDGG 381

  Fly   328 TLYLARDIAALLERLSRFQFSRLLYVVDNGQADHFNALFKTTAAL---DDRLSLEQLQHVKFGRI 389
            ..|...|:||:.:||...:.::::||||||||.||..:|.....:   |.:::  ::.||.||.:
  Rat   382 YTYDTSDLAAIKQRLFEEKANKIIYVVDNGQATHFQTVFAAAQMIGWYDPKVT--RVAHVGFGVV 444

  Fly   390 YG-----MSTRQGKAIFLKDVLDE----ARDIMREKRNISATTRENYNLDDEHVCDILGVSAVLV 445
            .|     ..||.|:.:.|.|:|:|    :.|.::||......|.|........|    ....:..
  Rat   445 LGEDKKKFKTRSGETVRLMDLLEEGLRRSMDKLKEKERDKVLTEEELKAAQTSV----AYGCIKY 505

  Fly   446 NVLKQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSL--LDNFRDVDLD----------DIKP 498
            ..|...|..|:.||:.:.|...|:|...|.|...|:.|:  |.|..:..|.          |.:.
  Rat   506 ADLSHNRLNDYVFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQRAARETKIILDHEK 570

  Fly   499 DWKHFSTEPADALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNATSQALKR-LPVKQESSL 562
            :||           |...:.||.:.:.:..:.|....|.:|::.|....::.... ..|:::...
  Rat   571 EWK-----------LGRCILRFPEILQKILDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQT 624

  Fly   563 EKQLQ----RLLLFHAAKKTLRHGMELLGLRPLNQM 594
            .|.|:    |:||..|....:..|.::||::|:.:|
  Rat   625 GKVLKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	158/616 (26%)
		nt_trans	137..397	CDD:294020	94/274 (34%)
		Anticodon_Ia_like	436..594	CDD:299868	36/174 (21%)
Rars1	NP_001099247.2	Could be involved in the assembly of the multisynthetase complex. /evidence=ECO:0000250	1..72		17/63 (27%)
		Arg_tRNA_synt_N	79..166	CDD:214975	16/92 (17%)
		PLN02286	80..660	CDD:215160	158/612 (26%)
		ArgRS_core	193..457	CDD:185675	94/275 (34%)
		L-arginine binding. /evidence=ECO:0000250\|UniProtKB:P54136	200..202		1/1 (100%)
		'HIGH' region. /evidence=ECO:0000250	201..212		8/10 (80%)
		Anticodon_Ia_like	498..660	CDD:299868	37/176 (21%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q05506	529..543		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.730