DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS-m and mrs1

DIOPT Version :9

Sequence 1:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_596077.1	Gene:	mrs1 / 2540548	PomBaseID:	SPBC25B2.09c	Length:	618	Species:	Schizosaccharomyces pombe

Alignment Length:	489	Identity:	183/489 - (37%)
Similarity:	272/489 - (55%)	Gaps:	46/489 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 VVEYSSPNIAKPFHVGHLRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGVQLLNVSD 202
            |:|:||||||||||.|||||||||:.||||||..|::..|:|||||||.|||||.:|.:.....|
pombe   144 VIEFSSPNIAKPFHAGHLRSTIIGSFLANLHESQGWKVHRVNYLGDWGKQFGLLAIGYKKYGDED 208

  Fly   203 KEMQLSPIETLYKSYVAANKAAEQRPEIAQ---------------------QARDLFAALEGGTD 246
             :::.:||..||..||..|..|.:..|..|                     :||:.|..:|.|.:
pombe   209 -QLKSNPIRHLYDVYVKVNADATEEDEKIQKDKAEAESKGLPYTPPLSLHDKAREFFKRMEDGDE 272

  Fly   247 KSMAKKWQQYRNYTIEDLSKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREI 311
            :|: |.|.::|:.:|..|...|:||.:|:|.|:.|||.|.:.:..::|:|||..|:  |.||..:
pombe   273 ESL-KVWARFRDLSITKLKDTYDRLNIHYDEYDGESQVSLELMNKMVDELRSLNLI--EEDGGAL 334

  Fly   312 VVVD--------GRRIPVIKSNGSTLYLARDIAALLERLSRFQFSRLLYVVDNGQADHFNALFKT 368
             ::|        |:.| |.|.:|:||||.|||....:|..:::|.:.:|||.:.|..:|:.|||.
pombe   335 -LIDLSKHDKKLGKAI-VQKRDGTTLYLTRDIGTAYKRYEKYKFDKSIYVVSSQQDMYFSQLFKI 397

  Fly   369 TAALDDRLSLEQLQHVKFGRIYGMSTRQGKAIFLKDVLDEARDIMREKRNISATTRENYNL--DD 431
            ...:....: ::..|:.:|.:.|||||:|||:||.|:::.|::   |...:.....|.|..  :.
pombe   398 FELMGFDWA-KKCVHINYGLVQGMSTRKGKAVFLDDIMEVAKE---EMHKVMQKNEEKYAQVENP 458

  Fly   432 EHVCDILGVSAVLVNVLKQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSLLDNFRDVDLDDI 496
            |.|.||:|.:|:.:.....:|..::.|.|.:.....||||..|||.|.||.|:..|....| ::|
pombe   459 EEVADIVGKTAIRIQDSTGKRINNYAFDWSRMTSFEGDTGPYLQYAHSRLSSVRRNVNYTD-EEI 522

  Fly   497 KPDWKHFSTEPADALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNATSQALKRLPVK-QES 560
            ........||| ||.||:..|.::...:..:....|...:|.|||.|.:|.|:....|.|: :|.
pombe   523 MGANLELLTEP-DAYDLVRLLGQYPDVLKNAFRFQETSTVVTYLFKLTHAVSKLYDILWVRGRER 586

  Fly   561 SLEKQLQRLLLFHAAKKTLRHGMELLGLRPLNQM 594
            .:  ||.||.||.|||:.|.:||.||||.||.:|
pombe   587 DI--QLARLALFGAAKQVLNNGMTLLGLTPLERM 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	182/487 (37%)
		nt_trans	137..397	CDD:294020	112/287 (39%)
		Anticodon_Ia_like	436..594	CDD:299868	58/158 (37%)
mrs1	NP_596077.1	ArgS	30..618	CDD:223097	182/487 (37%)
		Arg_tRNA_synt_N	34..112	CDD:214975
		ArgRS_core	144..425	CDD:185675	112/287 (39%)
		Anticodon_Ia_Arg	463..618	CDD:153410	58/158 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	221	1.000	Domainoid score	I546
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5707
Inparanoid	1	1.050	284	1.000	Inparanoid score	I655
OMA	1	1.010	-	-		QHG60659
OrthoFinder	1	1.000	-	-		FOG0004604
OrthoInspector	1	1.000	-	-		oto102021
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	1	1.100	-	-	LDO	PTHR11956
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	1	1.000	-	-		X3222
TreeFam	1	0.960	-	-
	14	13.860