DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArgRS-m and Rars2

DIOPT Version :9

Sequence 1:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_852071.2	Gene:	Rars2 / 109093	MGIID:	1923596	Length:	578	Species:	Mus musculus

Alignment Length:	561	Identity:	202/561 - (36%)
Similarity:	316/561 - (56%)	Gaps:	26/561 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VPVKKQQLQNSRRPTVEWILPSAFAQQEVELLDSLKKRRFEAYVENVRIVPSAGRSAAKIEFQLQ 111
            |||.|::.....:.:|:.:|.....:.:|:..|..::...:...:.|....|||  ...:.|::.
Mouse    31 VPVSKKEEVADFQLSVDSLLEDNNHKSQVDTQDQARRLAEKLKCDTVVTAISAG--PRTLNFKIN 93

  Fly   112 PQVFVEQLLQ--TKEIALHP------SPFAAEHIVVEYSSPNIAKPFHVGHLRSTIIGNVLANLH 168
            .::..:.:||  |::...:.      |....:.||||:|||||||.|||||||||||||.:|||.
Mouse    94 RELLTKAVLQQVTEDGCKYGLKSELFSDLPKKRIVVEFSSPNIAKKFHVGHLRSTIIGNFIANLK 158

  Fly   169 EHLGYRTTRLNYLGDWGTQFGLLVLGVQLLNVSDKEMQLSPIETLYKSYVAANKAAEQRPEIAQQ 233
            |.||::.||:||:||||.|||||..|.||....:| :|.:|::.|:..||..||.|.....:.:.
Mouse   159 EALGHQVTRINYIGDWGMQFGLLGTGFQLFGYEEK-LQTNPLQHLFDVYVQVNKEATDDKNVTKL 222

  Fly   234 ARDLFAALEGGTDKSMAKKWQQYRNYTIEDLSKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRS 298
            |.:.|..||.| |......||::|:.:||:.:::|.|||::||.|..||.| :::.||||..|.|
Mouse   223 AHEFFHRLEMG-DTQALSLWQRFRDLSIEEYTQIYKRLGIYFDEYSGESFY-REKSQDVLKLLDS 285

  Fly   299 AGLLQPEHDGREIVVVDGRR-----IPVIKSNGSTLYLARDIAALLERLSRFQFSRLLYVVDNGQ 358
            .||||...:|..:|.:.|..     ..|::|:|::||..||:||.:.|:.::.|..::||.|.||
Mouse   286 KGLLQKTAEGNVVVDLSGTGDLSSVCTVMRSDGTSLYATRDLAAAIHRMDKYNFDTMIYVADKGQ 350

  Fly   359 ADHFNALFKTTAALDDRLSLEQLQHVKFGRIYGMSTRQGKAIFLKDVLDEARDIMREKRNISATT 423
            ..||..:|:....:....: |:.|||.||.:.||.||:|...||:|||:|.:..|.:......||
Mouse   351 RRHFQQVFQMLKIMGYDWA-ERCQHVPFGIVKGMKTRRGGVTFLEDVLNEVQSRMLQNMASIKTT 414

  Fly   424 RENYNLDDEHVCDILGVSAVLVNVLKQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSLLDNF 488
            ::..|  .:...:.:|::||::...:.....|::|||.:..|..||||:.|||||.||.||.:.|
Mouse   415 KQLEN--PQETAERVGLAAVIIQDFRGTLLSDYQFSWDRVFQSRGDTGVFLQYTHARLCSLEETF 477

  Fly   489 RDVDLDDIKPDWKHFSTEPADALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNATSQALKR 553
            ....|:|.......   || .::.:|..|.|||:.::.|.:.|:...:|:||..|.:..:.|.|.
Mouse   478 GCGYLNDSNVACLQ---EP-QSVSILQHLLRFDEVLYLSSQDLQPKHIVSYLLTLSHLAAVAHKT 538

  Fly   554 LPVKQESSLEKQLQRLLLFHAAKKTLRHGMELLGLRPLNQM 594
            |.|| :|..:....||.||.|.:..|.:||:|||:.|:.:|
Mouse   539 LQVK-DSPPDVAGARLHLFKAVRSVLANGMKLLGITPVCRM 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	195/539 (36%)
		nt_trans	137..397	CDD:294020	118/264 (45%)
		Anticodon_Ia_like	436..594	CDD:299868	55/157 (35%)
Rars2	NP_852071.2	ArgS	30..578	CDD:223097	201/559 (36%)
		ArgRS_core	126..388	CDD:185675	118/265 (45%)
		'HIGH' region	133..144		9/10 (90%)
		L-arginine binding. /evidence=ECO:0000250\|UniProtKB:P54136	133..135		1/1 (100%)
		Anticodon_Ia_like	425..578	CDD:299868	55/157 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834470
Domainoid	1	1.000	250	1.000	Domainoid score	I2108
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5707
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2526
Isobase	1	0.950	-	0	Normalized mean entropy	S1330
OMA	1	1.010	-	-		QHG60659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004604
OrthoInspector	1	1.000	-	-		oto95091
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	1	1.100	-	-	LDO	PTHR11956
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	1	1.000	-	-		X3222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740