DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArgRS-m and Rars

DIOPT Version :9

Sequence 1:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_080212.2	Gene:	Rars / 104458	MGIID:	1914297	Length:	660	Species:	Mus musculus

Alignment Length:	694	Identity:	174/694 - (25%)
Similarity:	290/694 - (41%)	Gaps:	154/694 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CNA--------LKELTERMIRLRQAIC-EQLPHL-----KNACYALEVPVKKQQLQNSRR-PTVE 63
            |:|        :|.||..:.||:...| |..|.|     :|......:.:.::.||..|| ||..
Mouse     8 CSARLLQQEREIKALTAEIDRLKNCGCLEASPSLEQLREENLKLKYRLNILRRSLQEERRKPTKN 72

  Fly    64 WILPSAFAQQEVELLDSLKKRRFEAY----------VENVRIVPSAGRSAAKIEFQLQPQVFVEQ 118
            .|              ::..|..|.:          :||..::.:..:.....::|....:.:.|
Mouse    73 MI--------------NINSRLQEVFGCAIRAAYPDLENPPLIVTPSQQPKFGDYQCNSAMGISQ 123

  Fly   119 LLQTKEIALHPSPFA-------------------------------------------------- 133
            :|:.||..:.|...|
Mouse   124 MLKAKEQKVSPREIAENITKHLPNNKYIDKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPVL 188

  Fly   134 --AEHIVVEYSSPNIAKPFHVGHLRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGVQ 196
              .|.::|::|||||||..|||||||||||..::.|.|..||...|||::||||||||:|:..:|
Mouse   189 GDKEKVIVDFSSPNIAKEMHVGHLRSTIIGESMSRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQ 253

  Fly   197 -----LLNVSDKEMQLSPIETLYKSYVAANKAAEQRPEIAQQARDLFAALEGGTDKSMAKKWQQY 256
                 .|.||      .||..|...|..:.|..:...|..::|......|: ..:..:.|.|...
Mouse   254 DKFPDYLTVS------PPIGDLQAFYKESKKRFDADEEFKKRAYQCVVLLQ-SKNPDIMKAWNLI 311

  Fly   257 RNYTIEDLSKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREIVVVDGRRIP- 320
            .:.:.|:..|:|:.|.:..  .|....:.|.:::|::.:....|.:|.: |||:||.|.|..:|
Mouse   312 CDVSREEFKKIYDALDITL--IERGESFYQDRMKDIVKEFEDKGFVQVD-DGRKIVFVPGCSVPL 373

  Fly   321 -VIKSNGSTLYLARDIAALLERLSRFQFSRLLYVVDNGQADHFNALFKTTAAL---DDRLSLEQL 381
             ::||:|...|...|:||:.:||...:.::::||||||||.||..:|.....:   |.:::|  :
Mouse   374 TIVKSDGGYTYDTSDLAAIKQRLFEEKANKIIYVVDNGQAIHFQTIFAAAQMIGWYDPKVTL--V 436

  Fly   382 QHVKFGRIYG-----MSTRQGKAIFLKDVLDE----ARDIMREKRNISATTRENYNLDDEHVCDI 437
            .||.||.:.|     ..||.|:.:.|.|:|:|    :.|.::||......|.|........|
Mouse   437 THVGFGVVLGEDKKKFKTRSGETVRLMDLLEEGLKRSMDKLKEKERDKVLTEEELKAAQTSV--- 498

  Fly   438 LGVSAVLVNVLKQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSL--LDNFRDVDLD------ 494
             ....:....|...|..|:.||:.:.|...|:|...|.|...|:.|:  |.|..:..|.
Mouse   499 -AYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEAMLQRAARET 562

  Fly   495 ----DIKPDWKHFSTEPADALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNATSQALKR-L 554
                |.:.:||           |...:.||.:.:.:..:.|....|.:|::.|....::.... .
Mouse   563 KIILDHEKEWK-----------LGRCILRFPEILQKILDDLFLHTLCDYIYELATTFTEFYDSCY 616

  Fly   555 PVKQESSLEKQLQ----RLLLFHAAKKTLRHGMELLGLRPLNQM 594
            .|:::....|.|:    |:||..|....:..|.::||::|:.:|
Mouse   617 CVEKDRQTGKVLKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	154/624 (25%)
		nt_trans	137..397	CDD:294020	95/274 (35%)
		Anticodon_Ia_like	436..594	CDD:299868	36/174 (21%)
Rars	NP_080212.2	Could be involved in the assembly of the multisynthetase complex	1..72		18/63 (29%)
		Arg_tRNA_synt_N	79..166	CDD:214975	11/86 (13%)
		PLN02286	80..660	CDD:215160	153/606 (25%)
		ArgRS_core	193..457	CDD:185675	95/275 (35%)
		L-arginine binding. /evidence=ECO:0000250\|UniProtKB:P54136	200..202		1/1 (100%)
		'HIGH' region	201..212		8/10 (80%)
		Anticodon_Ia_like	498..660	CDD:299868	37/176 (21%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q05506	529..543		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.760