DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10086 and CG18747

DIOPT Version :9

Sequence 1:	NP_649736.3	Gene:	CG10086 / 40920	FlyBaseID:	FBgn0037517	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_652650.2	Gene:	CG18747 / 59143	FlyBaseID:	FBgn0042104	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	142/467 - (30%)
Similarity:	231/467 - (49%)	Gaps:	98/467 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKNCMITFDQNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQWRIRRHGKAVAIQN 65
            |...|.|:||.|:|||::.||::.|...:..:::|:::.:.|::.||:..:|..:..|
  Fly     1 MVVTCEISFDNNKHGTFYAGQLVKGCATLKCDRSKEVQAVLLKVVGYSITKWSEKSLG------- 58

  Fly    66 PKKRSKHQYSGREDYIASTTYLMGSEQGSNFN------MDAGTYTYTFACPIPSHCPSSFEGAYG 124
                |...|.|||||::|.|||:||||.:..|      ::||.::|.|.|.:|..|||||||.:|
  Fly    59 ----STKLYVGREDYLSSNTYLVGSEQNNTHNNTHRLTIEAGVHSYNFTCQLPYQCPSSFEGRHG 119

  Fly   125 HIRYLAKVTFLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEHFCL--MHTKPVQLKV 187
            .|||:.||..::|...::.:..||||||:||||.:|..|:..|.:|....||.  ..|.|::|::
  Fly   120 CIRYIVKVLLIRPWKFDQAYTKGFTVLKMLDLNFDTPQLKSAAHSEGYRTFCCGPCKTDPLKLEL 184

  Fly   188 TLQQQGYVPGQFMLIHAHVRNDSS---SDCRKLLIMLHLRATYTADTPSLRTTSEKIMLVKRECG 249
            .|.|.||||||.:.:...|.|:::   |:.|..|:||   ..|.:.:|. .:..|::::.:.:..
  Fly   185 HLPQAGYVPGQKIPVTIVVVNNTAVAVSEIRLSLVML---VRYYSVSPE-HSRVERLIISRAKGE 245

  Fly   250 PVAHNAQRTYTETLRIPATAPTCEHLSKVVRVSYEVRVVAVMNWLMANPRLIIPVTIGNVPLATA 314
            .|.....|:.|..|.:|:|.|||..||.:::::|::.|.|::..|.....:::|||:|.:|||.:
  Fly   246 SVLKQCTRSQTIDLPVPSTPPTCVELSNLIQIAYQLEVEALVKSLREQQLMVMPVTVGTIPLAVS 310

  Fly   315 -------------VSGPDFLPTNAFPSGSSLPADLPCTSTRAMELAQMAASGVSNSGYEMAEDLE 366
                         ..|||        |..:.|.:||                       |...||
  Fly   311 GIVVQQPPRRSAHYEGPD--------SRRNPPDELP-----------------------MVTALE 344

  Fly   367 DFELPEDGDDELEAADDFVPDLPPPTYEQAMFMTTDIADTDANTVSE-------ASRFTPRYPVF 424
              .||.|...  .|||..:|:     ||::       ..|....::|       ::.|.|.|||:
  Fly   345 --SLPSDLAS--SAADSALPN-----YEES-------RHTQRGNINEEELHAFGSNEFAPLYPVY 393

  Fly   425 DVDTFQSPPPNP 436
            .:     |.|.|
  Fly   394 SI-----PSPTP 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:278754	61/157 (39%)
CG10086	NP_649736.3	Arrestin_C	179..308	CDD:280848	39/131 (30%)
CG18747	NP_652650.2	Arrestin_N	5..152	CDD:278754	61/157 (39%)
CG18747	NP_652650.2	Arrestin_C	176..307	CDD:214976	40/134 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464040
Domainoid	1	1.000	139	1.000	Domainoid score	I9790
eggNOG	1	0.900	-	-		E1_KOG3780
Homologene	1	1.000	-	-		H119234
Inparanoid	1	1.050	43	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110793at6960
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
	11	10.900