DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10086 and CG18746

DIOPT Version :9

Sequence 1:	NP_649736.3	Gene:	CG10086 / 40920	FlyBaseID:	FBgn0037517	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_652649.1	Gene:	CG18746 / 59142	FlyBaseID:	FBgn0042103	Length:	438	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	137/478 - (28%)
Similarity:	216/478 - (45%)	Gaps:	69/478 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CMITFDQNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQWRIRRHGKAVAIQNPKKR 69
            |.|.|..|..|.::.||:|:|:|::...|.|.::.:.|.|.|||:..|....|       :|..:
  Fly     4 CEIEFCNNSQGIFYAGQLISGQVVIKTEKEKSVKAVILNIKGYAETHWADTEH-------DPDDQ 61

  Fly    70 SK-HQYSGREDYIASTTYLMGSEQGSNFNMDAGTYTYTFACPIPSHCPSSFEGAYGHIRYLAKVT 133
            |. ..::|..||:|:..||.||.......::.||.:|.|||.:|..|||||||..|.||||..|.
  Fly    62 SNGESFNGHVDYLATRAYLHGSSSSIEVLIEPGTSSYRFACQLPITCPSSFEGTLGRIRYLVNVR 126

  Fly   134 FLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEHFCLM--HTKPVQLKVTLQQQGYVP 196
            |::|...:...|..|||:|::|||.|:.|||.|:..|:...||..  .:.|:.:::::.|.|:||
  Fly   127 FVRPWKFDLNFNRCFTVIKVMDLNSESLMLRVPSQVESQRTFCCFPCRSSPLSMRLSVPQSGFVP 191

  Fly   197 GQFMLIHAHVRNDSSSDCRKLLIMLHLRATYTADTPSLRTTSEKIMLVKRECGPVAHNAQRTYTE 261
            ||.:.:...|.|||......:.:.|.:...|.:..||..|..::..:|.:..|.|:...::.:|.
  Fly   192 GQIVPVEVMVSNDSGVAVEDITVKLTMVVIYYSQPPSADTNKDRFEMVLKTGGGVSTKCRQQFTF 256

  Fly   262 TLRIPATAPTCEHLSKVVRVSYEVRVVAVMNWLMANPRLIIPVTIGNVPLATAVSGPDFLPTNAF 326
            .|::|.|.|||.:|..::::.|:|...|.:........|.:|:|||:|||...:...
  Fly   257 DLKVPPTPPTCFNLCSIIQIGYQVEAEARVKGCHGGQSLHMPITIGSVPLTKQLQKE-------- 313

  Fly   327 PSGSSLPADLPCTSTRAMELAQMAASGVSNSGYEM-AEDLEDFELPEDGDDELEAADDFVPDLPP 390
                      |.|....:...|:.|..:...|.|. .|.|        |.....|||   |.:.|
  Fly   314 ----------PRTWGEVLPPQQLDAKALILIGSEQNGEAL--------GSPNPWAAD---PSIAP 357

  Fly   391 PTYEQAMFMTTD------------------IADTDANTVSEASRFTPRYPVFDVDTFQSPPPNPP 437
            |:|.:|..::.|                  ..:..|.|:.    |:|.|.|||:.       |..
  Fly   358 PSYAEAKHISPDPHKFSKSKKKSQKRGVKGSQERKAETIV----FSPLYAVFDLS-------NQV 411

  Fly   438 QKKRRRRRRRPADPGQSKQQPEK 460
            .:...|......|.|...:..||
  Fly   412 DEMTLRANEPKTDGGYVNEGVEK 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:278754	57/152 (38%)
CG10086	NP_649736.3	Arrestin_C	179..308	CDD:280848	34/128 (27%)
CG18746	NP_652649.1	Arrestin_N	4..150	CDD:278754	57/152 (38%)
CG18746	NP_652649.1	Arrestin_C	174..306	CDD:214976	36/131 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464043
Domainoid	1	1.000	139	1.000	Domainoid score	I9790
eggNOG	1	0.900	-	-		E1_KOG3780
Homologene	1	1.000	-	-		H119234
Inparanoid	1	1.050	43	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110793at6960
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
	11	10.900