Protein Alignment CG10086 and ARRDC3

DIOPT Version :9

• Sequence 1: NP_649736.3
• Gene: CG10086 / 40920
• FlyBaseID: FBgn0037517
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_065852.1
• Gene: ARRDC3 / 57561
• HGNCID: 29263
• Length: 414
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 99/424 - (23%)
• Similarity: 179/424 - (42%)
• Gaps: 65/424 - (15%)

  Fly     3 KNCMITFD---QNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQW-RIRRHGKAVA- 62
            |:..|:||   .:....|.:|..::|:|.:.:....:::.:|:...|:|:.:| ..|..|...|
Human     7 KSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAY 71

  Fly    63 IQNPKKRSKHQYSGREDYIASTTYLMG-------SEQGSNFNMDAGTYTYTFACPIP-SHCPSSF 119
            .||        |:...:|......|:|       ||:|.: .:.:|.:.|.|:..:| :...:||
Human    72 TQN--------YTEEVEYFNHKDILIGHERDDDNSEEGFH-TIHSGRHEYAFSFELPQTPLATSF 127

  Fly   120 EGAYGHIRYLAKVTFLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEHFC--LMHTKP 182
            ||.:|.:||..|....:|..........|||.:.:|:|  |..|..|.:....:..|  ...:.|
Human   128 EGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDIN--TPSLLSPQAGTKEKTLCCWFCTSGP 190

  Fly   183 VQLKVTLQQQGYVPGQFMLIHAHVRNDSSSDCRKLLIMLHLRATYTADTPSLRTTSEKIMLVKRE 247
            :.|...::::||.||:.:.|.|.:.|.||........:...:|.|...  .::...:.:..::.|
Human   191 ISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKG--KMKEVKQLVANLRGE 253

  Fly   248 CGPVAHNAQRTYT---ETLRIPATAPTCEHLSKVVRVSYEVRVVAVMNWLMANPRLIIPVTIGNV 309
                :.::.:|.|   :.|:||..:|:....| ::||.|.:.|...:...| :..|.:|:.||.:
Human   254 ----SLSSGKTETWNGKLLKIPPVSPSILDCS-IIRVEYSLMVYVDIPGAM-DLFLNLPLVIGTI 312

  Fly   310 PL------ATAVSGPDFLPTN----AFPSGSSLP---ADLPCTSTRAMELAQMAASGVSNSGYEM 361
            ||      .::||....:..|    :.|.....|   |::.....|...||.::|
Human   313 PLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSA---------- 367

  Fly   362 AEDLEDFELPEDGDDELEAADDFVPDLPPPTYEQ 395
               .:|||....|  .|.|.......||||.|.:
Human   368 ---CDDFERALQG--PLFAYIQEFRFLPPPLYSE 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:278754	40/164 (24%)
		Arrestin_C	179..308	CDD:280848	29/131 (22%)
ARRDC3	NP_065852.1	Arrestin_N	22..165	CDD:334019	37/151 (25%)
		Arrestin_C	187..314	CDD:214976	30/134 (22%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		1/2 (50%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..414		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		mtm8525
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820