DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10086 and Arrdc3

DIOPT Version :9

Sequence 1:	NP_649736.3	Gene:	CG10086 / 40920	FlyBaseID:	FBgn0037517	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001007798.1	Gene:	Arrdc3 / 309945	RGDID:	1359478	Length:	414	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	107/487 - (21%)
Similarity:	190/487 - (39%)	Gaps:	115/487 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KNCMITFD---QNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQW-RIRRHGKAVA- 62
            |:..|:||   .:....|.:|..::|:|.:.:....:::.:|:...|:|:.:| ..|..|...|
  Rat     7 KSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAY 71

  Fly    63 IQNPKKRSKHQYSGREDYIASTTYLMGSEQGSN------FNMDAGTYTYTFACPIP-SHCPSSFE 120
            .||        |:...:|......|:|.|:..:      ..:.:|.:.|.|:..:| :...:|||
  Rat    72 TQN--------YTEEVEYFNHKDILIGHERDDDNCEEGFSTIHSGRHEYAFSFELPQTPLATSFE 128

  Fly   121 GAYGHIRYLAKVTFLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEHFC--LMHTKPV 183
            |.:|.:||..|....:|..........|||.:.:|:|  |..|..|.:....:..|  ...:.|:
  Rat   129 GRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDIN--TPSLLSPQAGTKEKTLCCWFCTSGPI 191

  Fly   184 QLKVTLQQQGYVPGQFMLIHAHVRNDSSSDCRKLLIMLHLRATYTADTPSLRTTSEKIMLVKREC 248
            .|...::::||.||:.:.|.|.:.|.||........:...:|.|...  .::...:.:..::.|
  Rat   192 SLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKG--KMKEVKQLVANLRGE- 253

  Fly   249 GPVAHNAQRTYT---ETLRIPATAPTCEHLSKVVRVSYE----VRVVAVMNWLMANPRLIIPVTI 306
               :.::.:|.|   :.|:||..:|:....| ::||.|.    |.:...|:.|::     :|:.|
  Rat   254 ---SLSSGKTETWDGKLLKIPPVSPSILDCS-IIRVEYSLMVYVDIPGAMDLLLS-----LPLVI 309

  Fly   307 GNVPL------ATAVSGPDFLPTNAFPSGSSLP---------ADLPCTSTRAMELAQMAASGVSN 356
            |.:||      .::||....:..|..  |.|||         |::.....|...||.::|
  Rat   310 GTIPLHPFGSRTSSVSSQCSMNMNWL--GLSLPERPEAPPSYAEVVTEEQRRNNLAPVSA----- 367

  Fly   357 SGYEMAEDLEDFELPEDGDDELEAADDFVPDLPPPTYEQAMFMTTDIADTDANTVSEASRFTPRY 421
                    .:|||....|  .|.|.......||||.|.
  Rat   368 --------CDDFERALQG--PLFAYIQEFRFLPPPLYS--------------------------- 395

  Fly   422 PVFDVDTFQSPPPNPPQKKRRRRRRRPADPGQ 453
               ::|      |||.|..    ..||:.|.:
  Rat   396 ---EID------PNPDQSS----EDRPSCPSR 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:278754	38/163 (23%)
CG10086	NP_649736.3	Arrestin_C	179..308	CDD:280848	29/135 (21%)
Arrdc3	NP_001007798.1	Arrestin_N	22..165	CDD:395268	35/150 (23%)
		Arrestin_C	187..314	CDD:214976	30/138 (22%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		0/2 (0%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..414		9/60 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		mtm12328
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820