DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10086 and arrd-5

DIOPT Version :9

Sequence 1:	NP_649736.3	Gene:	CG10086 / 40920	FlyBaseID:	FBgn0037517	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_496119.1	Gene:	arrd-5 / 191469	WormBaseID:	WBGene00014161	Length:	378	Species:	Caenorhabditis elegans

Alignment Length:	470	Identity:	98/470 - (20%)
Similarity:	167/470 - (35%)	Gaps:	143/470 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CMITFDQNEHGTYFTGQVITGKVIVNLNKTK-KLRGIKLQISGYAQAQWRIRRHGKAVAIQNPK- 67
            |::.|.::. ..:..|:.:||.|.:.:...: |.|.:::::.|.|...|..........|:|..
Worm     4 CLVEFAKSP-PVFSPGEKVTGNVKMTIPDDEFKARKVRMEMIGKAYTYWEGNVRNNHTKIKNGDI 67

  Fly    68 KRSKH---QYSGREDYIASTTYLMGSEQGSNFNMDAGTYTYTFACPIPSHCPSSFEGAYGHIRYL 129
            .|.:|   .:.|:..|....|.:..|: |:..:|.:|.:.:.|:..:|...|.||||..|.|||.
Worm    68 ARVRHNCADHKGKIVYCRFETIVWKSD-GAKNDMPSGPHIFPFSFQLPHWAPPSFEGDLGFIRYF 131

  Fly   130 AKVTFLKPGASNRTHNVGFTVLKLLDL----NQETKMLREPASNEAVEHF--CLMHTKPVQLKVT 188
            .||...:|...:.......|||..:||    |.:.     |:.....|.|  .|.....|::::.
Worm   132 IKVEIDRPWKFDDKFITCLTVLPNIDLRLIPNSQV-----PSKKHVCEEFGAVLWKNGLVRMELR 191

  Fly   189 LQQQGYVPGQFMLIHAHVRNDSSSDCRKLLIMLHLRATYTA---------DTPSLRTTSEKIMLV 244
            |.:||:|.|:.:.:...|.|.:|...:|:.:.|..|.|||.         ..|.:....|||...
Worm   192 LPKQGFVCGENIPVTMIVDNKTSKSFKKISLRLVQRVTYTGFRDGFVNSHSQPCIGNEKEKITYA 256

  Fly   245 KRECGPVAHNAQ-----RTYTET---LRI-----------------PATAPTCEHLSKVVRVSYE 284
            .|      .|||     |..:||   ::|                 |.:..|||    ::.|.|.
Worm   257 TR------LNAQTRVEERQISETNIDIKIDKNEKQEVEKPIPLPPLPPSTKTCE----IIDVEYF 311

  Fly   285 VRVVAVMNWLMANPRLIIPVTIGNVPLATAVSGPDFLPTNAFPSGSSLPADLPCTSTRAMELAQM 349
            ::|                                                            :|
Worm   312 LKV------------------------------------------------------------KM 316

  Fly   350 AASGVSNSGYEMAEDLEDFELPEDGDDELEAADDFVPDLPPPTYEQAM--FMTTDIADTDANTVS 412
            :.||...|..::........:|.|.:.:.|             |::::  |..|.:.:.|
Worm   317 STSGALKSAVKLELAFIIGTMPIDPERKYE-------------YKKSVFGFAATSLKNRD----- 363

  Fly   413 EASRFTPRYPVFDVD 427
             ..:|.|.||||..|
Worm   364 -VQKFAPLYPVFKFD 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:278754	41/160 (26%)
CG10086	NP_649736.3	Arrestin_C	179..308	CDD:280848	34/162 (21%)
arrd-5	NP_496119.1	Arrestin_N	4..158	CDD:334019	39/155 (25%)
arrd-5	NP_496119.1	Arrestin_C	182..338	CDD:214976	38/225 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H119234
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46400
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm14113
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.930