DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10086 and arrd-22

DIOPT Version :9

Sequence 1:	NP_649736.3	Gene:	CG10086 / 40920	FlyBaseID:	FBgn0037517	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_503955.1	Gene:	arrd-22 / 188642	WormBaseID:	WBGene00020612	Length:	456	Species:	Caenorhabditis elegans

Alignment Length:	494	Identity:	119/494 - (24%)
Similarity:	202/494 - (40%)	Gaps:	108/494 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ITFDQNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQWRIRRHGKAVAIQNPKKRSK 71
            :.|||.:. .:..||.|:|:|::...|....|.:.::|.|.|...|:        ..:|..|.|.
Worm     9 VIFDQPDE-VFLPGQPISGRVVLTTKKKLSARAVNIKIVGLAHTSWK--------NYENSCKLSF 64

  Fly    72 HQ----------YSGREDYIASTTYLMGSEQGSNFNMDAGTYTYTFACPIPSHCPSSFEGAYGHI 126
            |:          ||....|:..|..|....:|.. .::||.|.:.|:..:|.:.|.||||.||::
Worm    65 HRIVSYRPHGVYYSANVKYLDYTQLLWTCGEGPK-ELNAGEYAWPFSYTLPLNIPPSFEGKYGYL 128

  Fly   127 RYLAKVTFLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEHF--CLMHTKPVQLKVTL 189
            ||..||...:|...::...:..||..|||||.....| .|.:.:|.|:.  |......:::.|.:
Worm   129 RYTVKVEVDRPWRVDKAKKMCITVSPLLDLNVIPHSL-TPINTQASENLGCCCFKNGFLEMNVNI 192

  Fly   190 QQQGYVPGQFMLIHAHVRNDSSSDCRKLLIMLHLRATYTA------------------------D 230
            .:.|:|||:.:.::.|:.|.|||..:|:...:..:..:|.                        |
Worm   193 PKTGFVPGETVPLNIHLINHSSSTAKKIEAKILQQCKFTGYKDGATYNYGGDENMSEKAQRIMFD 257

  Fly   231 TPSLRTTSEKIMLVKRECGPVAHNAQRTYTETLRIPATAPTCEHLSKVVRVSYEVRV-VAVMNWL 294
            |.::...|:|::        ||...:..:...||||:..||....|.||.|.|.::: |......
Worm   258 TKTVVRESQKLV--------VAAKNEHKFVLELRIPSVTPTINQFSPVVTVEYLIQLKVDTSAMS 314

  Fly   295 MANPRLIIPVTIGNVPLATAV------SGPDFLPTNAFPSGSSLP-----ADLPCTSTRAMELAQ 348
            .:..|....:.:|:||:...:      ..|..||:...|.|..:.     ..||.|..
Worm   315 HSEVRCETSILLGSVPIRQCLPPSYYQQDPSVLPSKPTPIGEGVAPPPGYGSLPMTDD------- 372

  Fly   349 MAASGVSNSGYE------MAEDLEDFELP-----EDGDDELEAADDFVPDLPPPTYEQAMFMTTD 402
                  |..|.:      :..::.|..||     :||       :..:|..|||:|:::|:
Worm   373 ------SEKGTDAPYPLGLYPNVNDVNLPYPSVVQDG-------NAVIPSAPPPSYQESMY---- 420

  Fly   403 IADTDANTVSEASR---FTPRYPVFDVDTFQSPPPNPPQ 438
               ....||.:|..   :.|:||||:.....:|...||:
Worm   421 ---GKGGTVLDAKENEPYVPKYPVFNNLPVYNPTAPPPE 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:278754	46/159 (29%)
CG10086	NP_649736.3	Arrestin_C	179..308	CDD:280848	31/153 (20%)
arrd-22	NP_503955.1	Arrestin_N	7..159	CDD:334019	46/159 (29%)
arrd-22	NP_503955.1	Arrestin_C	182..330	CDD:214976	32/155 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I4648
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H119234
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46400
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm14113
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.930