DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10086 and arrd-18

DIOPT Version :9

Sequence 1:	NP_649736.3	Gene:	CG10086 / 40920	FlyBaseID:	FBgn0037517	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_503916.1	Gene:	arrd-18 / 178763	WormBaseID:	WBGene00018060	Length:	450	Species:	Caenorhabditis elegans

Alignment Length:	472	Identity:	118/472 - (25%)
Similarity:	213/472 - (45%)	Gaps:	70/472 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ITFDQNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQWR-----IRRHGKAVAIQNP 66
            :.|||.:. .:|.||.|:|:|::...:..|.|.:.::|.|.|...|:     .:.:|.:::|
Worm     9 VIFDQPDE-VFFPGQPISGRVVLTTKENYKARAVNIKILGLAHTSWKNYENACKFNGSSISI--- 69

  Fly    67 KKRSKHQYSGREDYIASTTYLMGSEQGSNFNMDAGTYTYTFACPIPSHCPSSFEGAYGHIRYLAK 131
            :.||.| ||...:|:..|..|...|.|.| .:.||.|.:.|:..:|:..|.||||.||::||..|
Worm    70 RPRSIH-YSANVNYLDYTQLLWTCEDGKN-ELAAGEYVWPFSYTLPTSIPPSFEGKYGYVRYTVK 132

  Fly   132 VTFLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEH--FCLMHTKPVQLKVTLQQQGY 194
            |...:|...::...:..||..|||||.....|.: .:::|.|:  ||......:::.:.:.:.|:
Worm   133 VEVDRPWRKDKAKKMCITVSPLLDLNVIPHSLTQ-INHQASENISFCCFQGGILEMSLNIPKTGF 196

  Fly   195 VPGQFMLIHAHVRNDSSSDCRKLLIMLHLRATYT-----------ADTPSLRTTSEKIMLVKREC 248
            |||:.:.::.|:.|.||:....:...:..:..:|           .|.......|:||..:|.:.
Worm   197 VPGETVPLNVHLINHSSTSVNNIKAQMLQQCKFTGYKSGATYNYGGDFERNEKMSDKIQRIKFDT 261

  Fly   249 GPVAHNAQR---------TYTETLRIPATAPTCEHLSKVVRVSY--EVRVVAVMNWLMANPRLII 302
            ..|....|:         .:...||||:..||....|.|:.|.|  :|.|..::       |...
Worm   262 KKVVKVCQKLEVPAKNEHKFVLELRIPSVTPTINQFSPVITVEYILQVNVDGLV-------RCES 319

  Fly   303 PVTIGNVPL------ATAVSGPDFLPTNAFPSGSSLPADLPCTSTRAMELAQMAASGVSNSGY-- 359
            .:.:|:||:      |.....|:..|:...|.|:..|...|..:..:.:.|        ::.|
Worm   320 SILLGSVPIHQYLPPAYYQQDPNLPPSKPTPIGAPPPGYGPLPTDDSEKGA--------DAPYPL 376

  Fly   360 EMAEDLEDFELPEDGDDELEAADDFVPDLPPPTYEQAMFMTTDIADTDANTVSEASR---FTPRY 421
            ::..::.|.::|...:|..:.....:|. .||:|:::|:       ..|.||.:|..   :.|:|
Worm   377 DLYPNVNDEKVPNPNEDPTKDGTAVLPS-APPSYQESMY-------GKAGTVLDAKENGPYVPKY 433

  Fly   422 PVFDVDTFQSPPPNPPQ 438
            |||:.....:|...||:
Worm   434 PVFNNLPVYNPTAPPPE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:278754	50/154 (32%)
CG10086	NP_649736.3	Arrestin_C	179..308	CDD:280848	29/150 (19%)
arrd-18	NP_503916.1	Arrestin_N	9..158	CDD:334019	50/154 (32%)
arrd-18	NP_503916.1	Arrestin_C	183..327	CDD:214976	30/150 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I4648
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H119234
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46400
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm14113
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930