Protein Alignment CG10086 and TXNIP

DIOPT Version :10

• Sequence 1: NP_649736.3
• Gene: CG10086 / 40920
• FlyBaseID: FBgn0037517
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_006463.3
• Gene: TXNIP / 10628
• HGNCID: 16952
• Length: 391
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 84/440 - (19%)
• Similarity: 160/440 - (36%)
• Gaps: 114/440 - (25%)

  Fly     3 KNCMITFDQNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQWRIRRHGKAVAIQNPK 67
            |:..:.|:..|. .|.:|:.:.|:|||.:.:..:::.:::...|.|:..|
Human     8 KSFEVVFNDPEK-VYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW--------------- 56

  Fly    68 KRSKHQYSGREDYIASTTYLMGSEQGSNFN----MDAGT-YTYTFACPIP-SHCPSSFEGAYGHI 126
            .:...|.....:|:.....|:..:|.:..|    |..|. |.|.|...:| ....:||:|.||.:
Human    57 MQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCV 121

  Fly   127 RYLAKVTFLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEHFCLMHTKPVQLKVTLQQ 191
            .|..|....:|....:.....|.|:.|:|:|....|....|..|.......:....|.:...:.:
Human   122 DYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDR 186

  Fly   192 QGYVPGQFMLIHAHVRNDSSSDCRKLLI---MLHLRATYTADTPSLRTTSEKIMLVKRECGPVAH 253
            :|:..|..:.|||    |..:.|.::::   .:..|.||.|:..: :..::|:..|:..     |
Human   187 KGFCEGDEISIHA----DFENTCSRIVVPKAAIVARHTYLANGQT-KVLTQKLSSVRGN-----H 241

  Fly   254 NAQRTYT----ETLRIPATAPT---CEHLSKVVRVSYEVRVVAVMNWLMANPRLIIPVTIGNVPL 311
            ....|..    ::||:....|:   |    .::||.|.               |:|.|::
Human   242 IISGTCASWRGKSLRVQKIRPSILGC----NILRVEYS---------------LLIYVSV----- 282

  Fly   312 ATAVSGPDFLPTNAFPSGSSLPADLPCTSTRAMELAQMAASGVSNSGYEMAEDLEDFELPEDGD- 375
                           |....:..|||........|:...:|..|.:..||:  ..|..:|:..:
Human   283 ---------------PGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMS--WVDLNIPDTPEA 330

  Fly   376 ----------------------DELEAADD-----FVPD---LPPPTYEQ 395
                                  |:::.:.|     :.|:   :|||||.:
Human   331 PPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTE 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:425619	34/157 (22%)
		Arrestin_C	180..311	CDD:214976	26/140 (19%)
TXNIP	NP_006463.3	Arrestin_N	10..152	CDD:451447	34/157 (22%)
		Arrestin_C	174..298	CDD:460676	30/172 (17%)