Protein Alignment Sp7 and TMPRSS5

DIOPT Version :10

• Sequence 1: NP_649734.2
• Gene: Sp7 / 40918
• FlyBaseID: FBgn0037515
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_110397.2
• Gene: TMPRSS5 / 80975
• HGNCID: 14908
• Length: 457
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 79/280 - (28%)
• Similarity: 119/280 - (42%)
• Gaps: 54/280 - (19%)

  Fly   127 KCGPHSFSNKVYNGNDTAIDEFNWMALLEYVDNRGRRELSCGGSLINNRYVLTAAHCVIGAVETE 191
            :||....::::..|...|...:.|.|.:..    |.|. :||||::..|:|:|||||
Human   208 ECGARPLASRIVGGQSVAPGRWPWQASVAL----GFRH-TCGGSVLAPRWVVTAAHC-------- 259

  Fly   192 VGHLTTVRLGEYDTSK-DVDCIDDICNQPILQLGIEQATVHPQYDPANKNRIHDIALLRLDRPVV 255
               :.:.||....:.: ....:.....:|.....:|:...||.|...|.:  :|:|||||...:.
Human   260 ---MHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHD--YDVALLRLQTALN 319

  Fly   256 LNEYIQPVCLPLVSTRMAINTGELLVVSGWGRTTTARKSTIKQRLDLPVNDHDYCARKFATRNIH 320
            .::.:..||||  :.......|....|||||.|..:               |.|.:.......:.
Human   320 FSDTVGAVCLP--AKEQHFPKGSRCWVSGWGHTHPS---------------HTYSSDMLQDTVVP 367

  Fly   321 LISSQLCVGGEFY-----------------RDSCDGDSGGPLMRRGFDQAWYQEGVVSFGNRCGL 368
            |.|:|||.....|                 .|:|.|||||||:....| .|...||||:|..|..
Human   368 LFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGD-TWRLVGVVSWGRGCAE 431

  Fly   369 EGWPGVYTRVADYMDWIVET 388
            ...||||.:||:::|||.:|
Human   432 PNHPGVYAKVAEFLDWIHDT 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:463440
		Tryp_SPc	137..388	CDD:238113	76/268 (28%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:464747	2/4 (50%)
		Tryp_SPc	217..448	CDD:214473	74/266 (28%)