DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sp7 and gzma

DIOPT Version :9

Sequence 1:	NP_649734.2	Gene:	Sp7 / 40918	FlyBaseID:	FBgn0037515	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	XP_001335166.1	Gene:	gzma / 795070	ZFINID:	ZDB-GENE-091204-156	Length:	257	Species:	Danio rerio

Alignment Length:	267	Identity:	75/267 - (28%)
Similarity:	107/267 - (40%)	Gaps:	58/267 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VYNGNDTAIDEFNWMALLEYVDNRGRRELSCGGSLINNRYVLTAAHCVIGAVETEVGHLTTVRLG 201
            :..|.|.. ...:||..::...|.     .|||.||:..:|||||||...:..:     .||.:|
Zfish    28 IVGGKDVK-KALSWMVSIQVNQNH-----KCGGILIHKEWVLTAAHCKEDSYSS-----VTVLIG 81

  Fly   202 EYDTSKDVDCIDDICNQPILQLGIEQATVHPQYDPA---NKNRIHDIALLRLDRPVVLNEYIQPV 263
            ....||                |.::..:|....|.   .|.:..||.|:||.:.|....|..|
Zfish    82 SLSLSK----------------GSQRIAIHNYEIPETFNKKTKKDDIMLIRLSKKVKAKPYKIP- 129

  Fly   264 CLPLVSTRMAINTGELLVVSGWGRTTTARK--STIKQRLDLPVNDHDYCARKFATRNIHLISSQL 326
                 .....:..|...||.|||.|....|  |...|.|::.|.|...|.| :..||..:....|
Zfish   130 -----KKEKDVQPGTKCVVRGWGTTDYKGKQASDKLQMLEVLVVDRVQCNR-YYNRNPVITKDML 188

  Fly   327 CVGG-EFYRDSCDGDSGGPLMRRGFDQAWYQE------GVVSFGNRCGLEGWPGVYTRVAD-YMD 383
            |.|. :.:|.:|.|||||||           |      ||:|..:.||....|.|||.::. ::.
Zfish   189 CAGNTQQHRGTCLGDSGGPL-----------ECEKNLVGVLSGSHGCGDPKKPTVYTLLSKRHIT 242

  Fly   384 WIVETIR 390
            ||.:.::
Zfish   243 WINKILK 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:288855
		Tryp_SPc	136..385	CDD:214473	73/260 (28%)
		Tryp_SPc	137..388	CDD:238113	75/263 (29%)
gzma	XP_001335166.1	Tryp_SPc	28..247	CDD:238113	75/263 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930