DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sp7 and gzmk

DIOPT Version :9

Sequence 1:	NP_649734.2	Gene:	Sp7 / 40918	FlyBaseID:	FBgn0037515	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	XP_017208551.1	Gene:	gzmk / 794999	ZFINID:	ZDB-GENE-091204-352	Length:	267	Species:	Danio rerio

Alignment Length:	273	Identity:	77/273 - (28%)
Similarity:	116/273 - (42%)	Gaps:	48/273 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 SPPKCGPHSFSNKVYNGNDTAIDEFNWMALLEYVDNRGRRELS-CGGSLINNRYVLTAAHCVIGA 187
            |.|.|...|    :..|.|.. ...:||..::      :.::. |||.||:.::|||:|.|
Zfish    29 SLPVCSDVS----IVGGKDVK-KALSWMVSIQ------KEKIHICGGILIHKQWVLTSAQC---- 78

  Fly   188 VETEVGHLTTVRLGEYDTSKDVDCIDDICNQPILQLGIEQATVHPQYDPANKNRIHDIALLRLDR 252
            .|..|..: ||.:|....||...           ::||....:...::  .|.:..||.|:||.:
Zfish    79 KEVPVSSV-TVLIGSLSLSKGSQ-----------RIGILNYEIPKTFN--EKTKEDDIMLIRLSK 129

  Fly   253 PVVLNEYIQPVCLPLVSTRMAINTGELLVVSGWGRT--TTARKSTIKQRLDLPVNDHDYCARKFA 315
            .|....|..|      .....:..|...||.|||.|  ...:.|...|.|::.|.|.|.|.| :.
Zfish   130 KVKAKPYKIP------KNEKDVPPGTKCVVRGWGTTDYKDEQASDKLQMLEVLVVDRDQCNR-YY 187

  Fly   316 TRNIHLISSQLCVGG-EFYRDSCDGDSGGPL-MRRGFDQAWYQEGVVSFGNRCGLEGWPGVYTRV 378
            .||..:....||.|. :.:|.:|.||||||| .::..      .||:|....||:...|.|||.:
Zfish   188 NRNPVITKDMLCAGNTQQHRGTCWGDSGGPLECKKNL------VGVISGSQGCGIPKKPTVYTFL 246

  Fly   379 AD-YMDWIVETIR 390
            :. ::.||...:|
Zfish   247 SKRHISWINSILR 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:288855
		Tryp_SPc	136..385	CDD:214473	70/254 (28%)
		Tryp_SPc	137..388	CDD:238113	72/256 (28%)
gzmk	XP_017208551.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587297
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930