DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sp7 and prss60.3

DIOPT Version :9

Sequence 1:	NP_649734.2	Gene:	Sp7 / 40918	FlyBaseID:	FBgn0037515	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	XP_002662541.2	Gene:	prss60.3 / 335152	ZFINID:	ZDB-GENE-030131-7092	Length:	330	Species:	Danio rerio

Alignment Length:	271	Identity:	87/271 - (32%)
Similarity:	126/271 - (46%)	Gaps:	36/271 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 CGPHSFSNKVYNGNDTAIDEFNWMALLEYVDNRGRRELSCGGSLINNRYVLTAAHCVIGAVETE- 191
            ||....:.::..|.:.:...:.|...|......|.   .||||||::.:|||||||:.|..||.
Zfish    27 CGQAPLNTRIVGGVNASPGSWPWQVSLHSPKYGGH---FCGGSLISSEWVLTAAHCLSGVSETTL 88

  Fly   192 ---VGHLTTVRLGEYDTSKDVDCIDDICNQPILQLGIEQATVHPQYDPANKNRIHDIALLRLDRP 253
               :|..|...:..|:||::|                .::.||..|: :|.|. :|||||||...
Zfish    89 VVYLGRRTQQGINIYETSRNV----------------AKSFVHSSYN-SNTND-NDIALLRLSSA 135

  Fly   254 VVLNEYIQPVCLPLVSTRMAINTGELLVVSGWG---RTTTARKSTIKQRLDLPVNDHDYCARKFA 315
            |....||:|||  |.:.....:.|....::|||   .........|.|...:||..:|.|.....
Zfish   136 VTFTNYIRPVC--LAAQNSVYSAGTSSWITGWGDIQAGVNLPAPGILQETMIPVVANDRCNALLG 198

  Fly   316 TRNI--HLISSQLCVGGEFYRDSCDGDSGGPLMRRGFDQAWYQEGVVSFGNRCGLEGWPGVYTRV 378
            :..:  ::|.:.|..||   :|:|.||||||::.| ....|.|.|:.|:|..|.....|||||||
Zfish   199 SGTVTNNMICAGLTQGG---KDTCQGDSGGPMVTR-LCTVWVQAGITSWGYGCADPNSPGVYTRV 259

  Fly   379 ADYMDWIVETI 389
            :.|..||...|
Zfish   260 SQYQSWISSKI 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:288855
		Tryp_SPc	136..385	CDD:214473	82/257 (32%)
		Tryp_SPc	137..388	CDD:238113	84/259 (32%)
prss60.3	XP_002662541.2	Tryp_SPc	36..269	CDD:238113	84/259 (32%)
prss60.3	XP_002662541.2	Somatomedin_B	294..328	CDD:321959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930