Protein Alignment Sp7 and HPN

DIOPT Version :10

• Sequence 1: NP_649734.2
• Gene: Sp7 / 40918
• FlyBaseID: FBgn0037515
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 89/302 - (29%)
• Similarity: 129/302 - (42%)
• Gaps: 88/302 - (29%)

  Fly   128 CGPHSFS-NKVYNGNDTAIDEFNWMALLEYVDNRGRRELSCGGSLINNRYVLTAAHC-------- 183
            ||..... :::..|.||::..:.|...|.|....     .|||||::..:|||||||
Human   153 CGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAH-----LCGGSLLSGDWVLTAAHCFPERNRVL 212

  Fly   184 -----VIGAVETEVGHLTTVRLGEYDTSKDVDCIDDICNQPILQLGIEQATVHPQY----DPANK 239
                 ..|||.....|      |                   ||||::....|..|    ||.::
Human   213 SRWRVFAGAVAQASPH------G-------------------LQLGVQAVVYHGGYLPFRDPNSE 252

  Fly   240 NRIHDIALLRLDRPVVLNEYIQPVCLPLVSTRMAINTGELLVVSGWGRTT-TARKSTIKQRLDLP 303
            ...:||||:.|..|:.|.|||||||||  :...|:..|::..|:|||.|. ..:::.:.|...:|
Human   253 ENSNDIALVHLSSPLPLTEYIQPVCLP--AAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVP 315

  Fly   304 VNDHDYCARKFATRNIHLISSQLCVGGEFYR-----------------DSCDGDSGGPLMRR--- 348
            :                 ||:.:|.|.:||.                 |:|.||||||.:..
Human   316 I-----------------ISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSI 363

  Fly   349 GFDQAWYQEGVVSFGNRCGLEGWPGVYTRVADYMDWIVETIR 390
            .....|...|:||:|..|.|...|||||:|:|:.:||.:.|:
Human   364 SRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:463440
		Tryp_SPc	137..388	CDD:238113	86/288 (30%)
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	2/5 (40%)
		Tryp_SPc	163..400	CDD:238113	84/285 (29%)