DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sp7 and F10

DIOPT Version :9

Sequence 1:	NP_649734.2	Gene:	Sp7 / 40918	FlyBaseID:	FBgn0037515	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_058839.1	Gene:	F10 / 29243	RGDID:	61850	Length:	482	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	109/412 - (26%)
Similarity:	169/412 - (41%)	Gaps:	93/412 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NPNQKQGQC---LSIYDCQSLLSVIQQSYVSPEDRTFLRNSQCLDGVG-------RQPYVCCTSD 87
            :|.|.||:|   |..|.|     ...:.:.......|:|....||...       .|..|.|:..
  Rat    93 SPCQNQGECRDGLGSYTC-----TCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCA 152

  Fly    88 RSF----GSQEATSAAPPPTTTSSSSRGQDGQA-GLGNLLPSP-----------PKCGPHSFSN- 135
            :.:    ..:...|.||.|...::..|.:...| ...|..|.|           |...|....|
  Rat   153 KGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNL 217

  Fly   136 -------------KVYNGNDTAIDEFNWMALL---EYVDNRGRRELSCGGSLINNRYVLTAAHCV 184
                         ::..|.:....|..|.|||   |..|.      .|||:::|..|:||||||:
  Rat   218 NKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDG------FCGGTILNEFYILTAAHCL 276

  Fly   185 IGAVETEVGHLTTVRLGEYDTSKD-----VDCIDDICNQPILQLGIEQATVHPQYDPANKNRIHD 244
            ..|...:      ||:|:.:|.::     |..:|.|......|        ...||       .|
  Rat   277 HQAKRFK------VRVGDLNTEQEDGGEMVHEVDMIIKHNKFQ--------RDTYD-------FD 320

  Fly   245 IALLRLDRPVVLNEYIQPVCLP----LVSTRMAINTGELLVVSGWGRT-TTARKSTIKQRLDLPV 304
            ||:|||..|:...|.:.|.|||    ..:|.|...||   :|||:||| ...|:|.:.:.:::|.
  Rat   321 IAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTG---IVSGFGRTHEKGRQSKVLKMMEVPY 382

  Fly   305 NDHDYCARKFATRNIHLISSQLCVGGEF-YRDSCDGDSGGPLMRRGFDQAWYQEGVVSFGNRCGL 368
            .|.:.|  :.:| :..:..:..|.|.:. ..|:|.||||||.:.| |...::..|:||:|..|..
  Rat   383 VDRNTC--RLST-SFSITQNMFCAGYDAKQEDACQGDSGGPHVTR-FKDTYFVTGIVSWGEGCAR 443

  Fly   369 EGWPGVYTRVADYMDWIVETIR 390
            :|..|:||:|..::.||..:::
  Rat   444 KGKYGIYTKVTAFLKWIDRSMK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:288855	14/60 (23%)
		Tryp_SPc	136..385	CDD:214473	80/262 (31%)
		Tryp_SPc	137..388	CDD:238113	82/264 (31%)
F10	NP_058839.1	GLA	23..84	CDD:214503
		EGF_CA	86..122	CDD:238011	8/33 (24%)
		FXa_inhibition	129..164	CDD:405372	5/34 (15%)
		Tryp_SPc	232..462	CDD:238113	82/263 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920