DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp7 and C1s

DIOPT Version :9

Sequence 1:	NP_649734.2	Gene:	Sp7 / 40918	FlyBaseID:	FBgn0037515	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_620255.2	Gene:	C1s / 192262	RGDID:	619983	Length:	694	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	113/415 - (27%)
Similarity:	172/415 - (41%)	Gaps:	92/415 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TCLLPFTVLQNVAAQGSCRNPNQKQGQ-------CLSIYDCQSLLSVIQQSYVSPEDRTFLRNSQ 71
            ||:..|.|::......|..:..|..||       |..: ||.....:.......|||..|
  Rat   326 TCVDGFEVVEGNVGSTSFYSTCQSNGQWSNSRLECQPV-DCGVPEPIENGKVEDPEDTVF----- 384

  Fly    72 CLDGVGRQPYVCCTSDRSFGSQEATSAAPPPTTTSSSSRGQDGQAGLGNLLPS-PPKCG----PH 131
                 |...:..|.....:..||...      ....::.|......||..||. .|.||    |.
  Rat   385 -----GSVIHYTCEEPYYYMEQEEGG------EYHCAANGSWVNDQLGVELPKCIPVCGVPTEPF 438

  Fly   132 SFSNKVYNGNDTAIDEFNWMALLEYVDNRGRRELSCGGSLINNRYVLTAAHCV---------IGA 187
            ....:::.|..|.|..|.|....|  ..||      ||:||:..:||||||.|         :|:
  Rat   439 KVQQRIFGGYSTKIQSFPWQVYFE--SPRG------GGALIDEYWVLTAAHVVEGNSDPVMYVGS 495

  Fly   188 VETEVGHLTTVRLGEYDTSKDVDCIDDICNQPILQLGIEQATVHP---QYDPAN--KNRIHDIAL 247
            ...::..|...:                      :|..|:..:||   |.|..|  .|..:||||
  Rat   496 TLLKIERLRNAQ----------------------RLITERVIIHPSWKQEDDLNTRTNFDNDIAL 538

  Fly   248 LRLDRPVVLNEYIQPVCLPLVSTRMAINTGELLVVSGWGRTTTARKSTIKQR-LDLPVNDHDYCA 311
            ::|..||.:...:.|:|||..|:....:.|:|.::||||||.. |.:.|:.| ..||:...:.|.
  Rat   539 VQLKDPVKMGPTVAPICLPETSSDYNPSEGDLGLISGWGRTEN-RTNVIQLRGAKLPITSLEKCQ 602

  Fly   312 R-----KFATRNIHLISSQLCVGGEFYRDSCDGDSGG------PLMRRGFDQAWYQEGVVSFGNR 365
            :     ..|..|.::.:..:...||...|||:|||||      |.::   |..:|..|:||:|.:
  Rat   603 QVKVENPKARSNDYVFTDNMICAGEKGVDSCEGDSGGAFALPVPNVK---DPKFYVAGLVSWGKK 664

  Fly   366 CGLEGWPGVYTRVADYMDWIVETIR 390
            ||..   |:||:|.:|:|||::|::
  Rat   665 CGTY---GIYTKVKNYVDWILKTMQ 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:288855	11/59 (19%)
		Tryp_SPc	136..385	CDD:214473	82/274 (30%)
		Tryp_SPc	137..388	CDD:238113	84/276 (30%)
C1s	NP_620255.2	CUB	24..135	CDD:238001
		FXa_inhibition	149..177	CDD:405372
		CUB	181..293	CDD:395345
		CCP	300..361	CDD:153056	8/34 (24%)
		CCP	365..428	CDD:153056	14/78 (18%)
		Tryp_SPc	443..681	CDD:214473	82/274 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000