DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp7 and F10

DIOPT Version :9

Sequence 1:	NP_649734.2	Gene:	Sp7 / 40918	FlyBaseID:	FBgn0037515	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_001229297.1	Gene:	F10 / 14058	MGIID:	103107	Length:	493	Species:	Mus musculus

Alignment Length:	410	Identity:	119/410 - (29%)
Similarity:	173/410 - (42%)	Gaps:	90/410 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NPNQKQGQC---LSIYDCQSLLSVIQQSYVSPEDRTFLR------NSQCLDGVGRQ---PYVC-C 84
            :|.|.||.|   :..|.|     ...:.:.......|:|      |..| |...|:   ..|| |
Mouse   105 SPCQNQGACRDGIGGYTC-----TCSEGFEGKNCELFVRKLCRLDNGDC-DQFCREEQNSVVCSC 163

  Fly    85 TSDRSFGS--QEATSAAPPP---TTTSSSSRG-----QDGQAGLGNLLPSPPKCGPHSFSNKVYN 139
            .|....|:  :...|.||.|   .||....|.     .|.:..|.:.|.......|.....::.|
Mouse   164 ASGYFLGNDGKSCISTAPFPCGKITTGRRKRSVALNTSDSELDLEDALLDEDFLSPTENPIELLN 228

  Fly   140 GNDTAID------------------EFNWMALLEYVDNRGRRELSCGGSLINNRYVLTAAHCVIG 186
            .|:|..:                  |..|.|||...||.|    .|||:::|..|:||||||:..
Mouse   229 LNETQPERSSDDLVRIVGGRECKDGECPWQALLINEDNEG----FCGGTILNEFYILTAAHCLHQ 289

  Fly   187 AVETEVGHLTTVRLGEYDTSKD-----VDCIDDICNQPILQLGIEQATVHPQYDPANKNRIHDIA 246
            |...:      ||:|:.:|.|:     |..:|.:......|        ...||       :|||
Mouse   290 ARRFK------VRVGDRNTEKEEGNEMVHEVDVVIKHNKFQ--------RDTYD-------YDIA 333

  Fly   247 LLRLDRPVVLNEYIQPVCLP----LVSTRMAINTGELLVVSGWGRT-TTARKSTIKQRLDLPVND 306
            :|||..|:.....:.|.|||    ..||.|...||   :|||:||| ...|:|.|.:.|::|..|
Mouse   334 VLRLKTPITFRMNVAPACLPQKDWAESTLMTQKTG---IVSGFGRTHEKGRQSNILKMLEVPYVD 395

  Fly   307 HDYCARKFATRNIHLISSQLCVGGEF-YRDSCDGDSGGPLMRRGFDQAWYQEGVVSFGNRCGLEG 370
            .:.|  |.:| :..:..:..|.|.|. ..|:|.||||||.:.| |...:|..|:||:|..|..:|
Mouse   396 RNTC--KLST-SFSITQNMFCAGYEAKLEDACQGDSGGPHVTR-FKNTYYVTGIVSWGEGCARKG 456

  Fly   371 WPGVYTRVADYMDWIVETIR 390
            ..|:||:|..::.||..:::
Mouse   457 KYGIYTKVTTFLKWIDRSMK 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:288855	15/63 (24%)
		Tryp_SPc	136..385	CDD:214473	88/277 (32%)
		Tryp_SPc	137..388	CDD:238113	90/279 (32%)
F10	NP_001229297.1	GLA	36..97	CDD:214503
		EGF_CA	98..134	CDD:238011	7/33 (21%)
		FXa_inhibition	141..176	CDD:291342	9/35 (26%)
		Tryp_SPc	243..471	CDD:214473	85/259 (33%)
		Tryp_SPc	244..473	CDD:238113	87/260 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910