Protein Alignment Sp7 and tmprss2.2

DIOPT Version :10

• Sequence 1: NP_649734.2
• Gene: Sp7 / 40918
• FlyBaseID: FBgn0037515
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: XP_002941330.2
• Gene: tmprss2.2 / 100493729
• XenbaseID: XB-GENE-22065949
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 489
• Identity: 118/489 - (24%)
• Similarity: 181/489 - (37%)
• Gaps: 149/489 - (30%)

  Fly    15 CLLPFTVLQNVAA------------QGSCRNPNQK--QGQCLSIYDC---QSLLSVIQQSYVSPE 62
            |::.|.|:..|||            :.....|:..  |..|...|.|   ..:...:|......:
 Frog    66 CIISFIVICKVAAIVAGLIIGFVVTKRPSTTPSTPTCQMYCSYTYTCIHAYQICDGVQDCRYGDD 130

  Fly    63 DR------------------TFLRNSQCLDGVGRQP----YVCCTSDRSFGSQE-------ATSA 98
            :|                  :.:|:||..|||.:.|    ...|.  |.:|:..       ..||
 Frog   131 ERNCGATLPANCEKRCGSSVSCVRSSQWCDGVSQCPNGEDETSCV--RLYGADSQLQVYSTLKSA 193

  Fly    99 APPPTTTSSSSR---------GQDGQA-GLGNLLPSP--P------------------------- 126
            ..|....:.|..         |..|.: ...|.||||  |
 Frog   194 WLPVCADNWSDAYGRFACRDFGYSGSSYNRSNTLPSPYAPNGYFKLNNGFGSSQFYTSVQNSSSC 258

  Fly   127 -----------KCGP--HSFSNKVYNGNDTAIDEFNWMALLEYVDNRGRRELSCGGSLINNRYVL 178
                       .||.  :|.::::..|...|...:.|...|.|  |.|   :.||||:|:.::::
 Frog   259 FSGNVVSLRCISCGVSYNSVASRIVGGTYAAYGNWLWQVGLRY--NTG---ILCGGSIISPKWIV 318

  Fly   179 TAAHCVIGAVETE------------VGHLTTVRLGEYDTSKDVDCIDDICNQPILQLGIEQATVH 231
            ||||||.|   |:            .|.||..  ..||:|..:               :|:...|
 Frog   319 TAAHCVYG---TDGFLLSASGWRVFAGTLTLP--SYYDSSGYL---------------VERIIPH 363

  Fly   232 PQYDPANKNRIHDIALLRLDRPVVLNEYIQPVCLPLVSTRMAINTGELLVVSGWGRTTT-ARKST 295
            |.|..::.:  :||||:.|...:......||||||  :..|..::|....:||||.|:. ...||
 Frog   364 PGYKTSSND--NDIALMELSNGITFGYNTQPVCLP--NAGMFWSSGTPCWISGWGTTSQGGSAST 424

  Fly   296 IKQRLDLPVNDHDYCARKFATRNIHLISSQLCVGGEFYR----DSCDGDSGGPLMRRGFDQAWYQ 356
            ..|...:.:.|.:.|.:.: ..|..:.:|.:|.|   |.    |||.|||||||:.: .:..|:.
 Frog   425 YLQYAAVQLIDSNVCNQNY-VYNGQITASMICAG---YLSGGVDSCQGDSGGPLVTK-TNGTWWL 484

  Fly   357 EGVVSFGNRCGLEGWPGVYTRVADYMDWIVETIR 390
            .|..|:|..|.....||||..:..::.||...:|
 Frog   485 VGDTSWGYGCAQPNKPGVYGNMTSFLGWIYLQMR 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp7	NP_649734.2	CLIP	31..84	CDD:463440	14/79 (18%)
		Tryp_SPc	137..388	CDD:238113	79/267 (30%)
tmprss2.2	XP_002941330.2	LDLa	<111..134	CDD:238060	3/22 (14%)
		LDLa	145..174	CDD:238060	7/28 (25%)
		SRCR_2	179..274	CDD:464747	15/94 (16%)
		Tryp_SPc	282..513	CDD:238113	77/264 (29%)