DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd3 and Upb1

DIOPT Version :9

Sequence 1:	NP_649732.1	Gene:	pyd3 / 40916	FlyBaseID:	FBgn0037513	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_598756.1	Gene:	Upb1 / 103149	MGIID:	2143535	Length:	393	Species:	Mus musculus

Alignment Length:	385	Identity:	242/385 - (62%)
Similarity:	298/385 - (77%)	Gaps:	1/385 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAFELKNLNDCLEKHLPPDELKEVKRILYGVEEDQTLELPTSAKDIAEQNGFDIKGYRFTAREE 65
            |:..|.::|..|||||||||:|.:||||||| ::.:.|:||..|...|.:..|::|||.|.|.:|
Mouse     1 MAGPEWQSLEQCLEKHLPPDDLAQVKRILYG-KQTRNLDLPREALKAASERNFELKGYAFGAAKE 64

  Fly    66 QTRKRRIVRVGAIQNSIVIPTTAPIEKQREAIWNKVKTMIKAAAEAGCNIVCTQEAWTMPFAFCT 130
            |.|..:|||||.:||.|.:||:||:.:|..|:...::.:.:.||..|.||:|.||||.|||||||
Mouse    65 QQRCPQIVRVGLVQNRIPLPTSAPVAEQVSALHKSIEEIAEVAAMCGVNIICFQEAWNMPFAFCT 129

  Fly   131 REKFPWCEFAEEAENGPTTKMLAELAKAYNMVIIHSILERDMEHGETIWNTAVVISNSGRYLGKH 195
            |||.||.||||.||:|.||:...:|||.:|||::..|||||.|||..:|||||||||||..:||.
Mouse   130 REKLPWTEFAESAEDGLTTRFCQKLAKKHNMVVVSPILERDREHGGVLWNTAVVISNSGLVMGKT 194

  Fly   196 RKNHIPRVGDFNESTYYMEGNTGHPVFETEFGKLAVNICYGRHHPQNWMMFGLNGAEIVFNPSAT 260
            |||||||||||||||||||||.|||||:|:||::|||||||||||.||:|:.:|||||:||||||
Mouse   195 RKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPLNWLMYSINGAEIIFNPSAT 259

  Fly   261 IGRLSEPLWSIEARNAAIANSYFTVPINRVGTEQFPNEYTSGDGNKAHKEFGPFYGSSYVAAPDG 325
            ||.|||.||.||||||||||..||..:||||.|.||||:|||||.|||.:.|.||||||||||||
Mouse   260 IGELSESLWPIEARNAAIANHCFTCALNRVGQEHFPNEFTSGDGKKAHHDLGYFYGSSYVAAPDG 324

  Fly   326 SRTPSLSRDKDGLLVVELDLNLCRQVKDFWGFRMTQRVPLYAESFKKASEHGFKPQIIKE 385
            ||||.|||::|||||.||:||||:|:.|||.|:||.|:.:||....:|.:..:.|.|:||
Mouse   325 SRTPGLSRNQDGLLVTELNLNLCQQINDFWTFKMTGRLEMYARELAEAVKPNYSPNIVKE 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd3	NP_649732.1	PLN00202	9..385	CDD:177792	238/375 (63%)
pyd3	NP_649732.1	ML_beta-AS	9..372	CDD:143611	235/362 (65%)
Upb1	NP_598756.1	PLN00202	6..392	CDD:177792	240/380 (63%)
Upb1	NP_598756.1	ML_beta-AS	9..371	CDD:143611	235/362 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837283
Domainoid	1	1.000	414	1.000	Domainoid score	I671
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9471
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1284
Isobase	1	0.950	-	0	Normalized mean entropy	S1576
OMA	1	1.010	-	-		QHG55618
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006264
OrthoInspector	1	1.000	-	-		oto94529
orthoMCL	1	0.900	-	-		OOG6_102400
Panther	1	1.100	-	-	LDO	PTHR43674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3768
SonicParanoid	1	1.000	-	-		X4546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740