Protein Alignment Nlg1 and CES2

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_003860.3
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 179/630 - (28%)
• Similarity: 283/630 - (44%)
• Gaps: 120/630 - (19%)

  Fly   124 VLATDEGSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLP 188
            :|...:|.....|..|.|                    .|:::|  ....|......|..|||:|
Human    20 LLVRGQGQDSASPIRTTH--------------------TGQVLG--SLVHVKGANAGVQTFLGIP 62

  Fly   189 YAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRT 253
            :|:.|.|..||.||..|..|.|::.....|.:|   |.||:...||.:|:......|..:
Human    63 FAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMC---LQDLTAVESEFLSQFNMTFPSDSM----- 119

  Fly   254 ESEDCLYLNLYVP--HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRL 316
             |||||||::|.|  ..|..:.|    |:|::||.:..:...:.||||:|::...|:||.:.|||
Human   120 -SEDCLYLSIYTPAHSHEGSNLP----VMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRL 179

  Fly   317 GVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVA 381
            |||||.... |.|...|:..|||:|||.|:::||..|||:..|||:.|.|.|...|:.|:|||::
Human   180 GVLGFFSTG-DKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPIS 243

  Fly   382 SGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILH 446
            .||||.||:.||.|:.....::.:..::..:|:...|      :..|.:.|:.|||.:..::||
Human   244 QGLFHGAIMESGVALLPGLIASSADVISTVVANLSAC------DQVDSEALVGCLRGKSKEEIL- 301

  Fly   447 IPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEEGLRE 511
               |:.:....:..:|||..:|..|.:::.                 |..:..:.::.   |:..
Human   302 ---AINKPFKMIPGVVDGVFLPRHPQELLA-----------------SADFQPVPSIV---GVNN 343

  Fly   512 NERDNLLRFYMQSRFDIRPDL---ALAATLKKYQDMYNNPIKATNLEHRDVVLD----------- 562
            ||...|:...|:. :|.:.::   |..|.|:|...:...|....:|...:.:.|
Human   344 NEFGWLIPKVMRI-YDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQF 407

  Fly   563 --ILSDARVVGPLLQTGMF---HADVNRRNYMYVFGHNSATGPFAHLPH--SIMGEELAFIFGAP 620
              :::|:..|.|.||...|   .|.|    |.|.|.|..:.......||  :..|:||.|:|.:
Human   408 QEMMADSMFVIPALQVAHFQCSRAPV----YFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRS- 467

  Fly   621 LAAAGPFPSGNY---TVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEF 682
                  |..|||   |.:|:.||..:|.||.||.:.|||         |...|.      .||.|
Human   468 ------FFGGNYIKFTEEEEQLSRKMMKYWANFARNGNP---------NGEGLP------HWPLF 511

  Fly   683 NRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQ 727
            ::..| ||.:.:.|.||...:...:.||.|.||.::.::...:|:
Human   512 DQEEQ-YLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEER 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	168/578 (29%)
CES2	NP_003860.3	COesterase	30..538	CDD:395084	171/601 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559		179/630 (28%)