DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and LOC688542

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_038954018.1	Gene:	LOC688542 / 688542	RGDID:	1587637	Length:	559	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	184/569 - (32%)
Similarity:	274/569 - (48%)	Gaps:	90/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 VDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLS 245
            |..|||:|:|:.|.|..||.||.||.||.|::.|...|.:|   |.:.:..|||:|     |.:.
  Rat    55 VHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDATSHPAMC---LQNDNMMGSEDM-----KIMK 111

  Fly   246 RLLPYLRTESEDCLYLNLYVP-H-EEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVI 308
            .:||.: :.||||||||:|.| | .|..:.|    |:|::||.:......:.||||:|::..:|:
  Rat   112 LILPPI-SMSEDCLYLNIYAPTHAHEGSNLP----VMVWIHGGALTVGMASMYDGSMLAATEDVV 171

  Fly   309 VVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVN 373
            |||:.||||||||.... |.|...|:..|||:|||.|:::||..|||:.:|||:.|.|.|...|:
  Rat   172 VVTIQYRLGVLGFFSTG-DEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGESAGGTSVS 235

  Fly   374 YLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRH 438
            ..:|||::.||||.||:.||..:.....|..|..:...:|:...|      .|.|.:.|:.|||.
  Rat   236 SHVVSPMSQGLFHGAIMESGVVVLPDLISRSSEMVYRIVANLSGC------AAVDSETLMQCLRG 294

  Fly   439 RRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAAL 503
            :...:||.|    .:....:..:|||..:|..|.:::.  :.:|.|...:.||...| |..:..:
  Rat   295 KSEAEILDI----NKVFKIIPAVVDGEFLPKHPQELLA--SANFHRVPSIIGINNDE-YGWILPM 352

  Fly   504 ALE--EGLRENERDNLLRFYMQSRFDIRPDLALAATLK-------------KYQDMYNNPIKATN 553
            ..:  :.:.|..|..|            |.:..:..||             :|.....:| |...
  Rat   353 IFDSAQKIEEITRKTL------------PTVLKSTALKMMLPPECGDLLMEEYMGDTEDP-KTLQ 404

  Fly   554 LEHRDVVLDILSDARVVGPLLQTGMF---HADVNRRNYMYVFGHNSATGPFAHLPH--SIMGEEL 613
            .:.|    :::.|...|.|.||...|   ||.|    |.|.|.|.|:.......||  :..|:|:
  Rat   405 AQFR----EMMGDFMFVIPALQVAHFQRSHAPV----YFYEFQHRSSFFKDVKPPHVKADHGDEV 461

  Fly   614 AFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLD 678
            ..:||. |.....||   :|.:|:|||..:|.||.||.:.|||         ||..|.      .
  Rat   462 FLVFGY-LVGDIKFP---HTEEEELLSRKIMKYWANFARHGNP---------NSEGLP------H 507

  Fly   679 WPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQ 727
            ||..:...| ||.:.|.|:||...:...:.||.|.||.::.::...||:
  Rat   508 WPVMDHDDQ-YLQLDIQPSVGRALKARRLKFWTKTLPQKIQELKGAQER 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	177/550 (32%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	61/146 (42%)
LOC688542	XP_038954018.1	COesterase	30..538	CDD:395084	177/550 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000