DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Ces2j

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	630	Identity:	185/630 - (29%)
Similarity:	276/630 - (43%)	Gaps:	130/630 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 ERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLR-----------QVDQFLGLPYAEAPTGN 196
            ||:..:||...::  ...:||:......|...|..:|           .:..|||:|:|:.|.|.
  Rat    28 ERKKGIPDSNLHS--FLTEQGQDSASPIRNTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGP 90

  Fly   197 RRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYL 261
            .||.||..|.||.|::.|...|.:|.|.       ...|:...:...|::|     ..|||||||
  Rat    91 LRFAPPEDPEPWSGVRDATSQPAMCLQT-------AMMNLEGMKETELTKL-----PMSEDCLYL 143

  Fly   262 NLYVP---HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLR 323
            |:|||   ||:     ....|:|::||......|.:..|.|.|::..|:::|::.||||||||..
  Rat   144 NIYVPAHAHED-----SNLPVMVWIHGGGLVGGSASMNDASTLAATEEIVIVSIQYRLGVLGFFS 203

  Fly   324 PSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRA 388
            .. |.|...|:..|||:|||.|:::||..|||:...||:.|.|.|...|:..:|||::.||||||
  Rat   204 TG-DQHARGNWGYLDQMAALRWVQQNIAYFGGNRDSVTIFGVSAGGTSVSSHVVSPMSKGLFHRA 267

  Fly   389 ILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQ 453
            |:.||.|:.....|:.|..:...:|:...|      ||.|.:.|:.|||.:..|:||    |:.|
  Rat   268 IMQSGVALLPGLISDTSEVVYKTVANLSGC------EASDSEALIRCLRAKSKQEIL----AINQ 322

  Fly   454 FSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESES----------YHTL-------- 500
            ....:..:|||..:|..|.:::.  ::.|.....:.|:...|.          ||.:
  Rat   323 VFKMIPGVVDGKFLPKHPQELLA--SKDFHPVPSIIGVNTDECGWGVPTILGLYHIINNITRETL 385

  Fly   501 -AAL---ALEEGLRENERDNLLRFYMQSRFDIRPDLALAATLK-KYQDMYNNPIKATNLEHRDVV 560
             |||   |.:..|.....|.::..||....|       |.||: ::::|
  Rat   386 PAALKIAAAQMMLPPECIDLIMEEYMGDTED-------AETLQAQFKEM---------------- 427

  Fly   561 LDILSDARVVGPLLQTGMF---HADVNRRNYMYVFGH----NSATGPFAHLPHSIMGEELAFIFG 618
               |.|...|.|.||...|   .|.|    |.|.|.|    .....||  .|.:..|::..|:||
  Rat   428 ---LGDFIFVIPALQVAHFQRSQAPV----YFYEFQHLLSFIKQVRPF--YPKADHGDDTVFVFG 483

  Fly   619 APLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDL-DWPEF 682
            :.....    :.:.|.:|:||...||.||.||.:||||...                || .||..
  Rat   484 SYFWGM----TFDLTEEEELLKRRVMKYWANFARTGNPNGE----------------DLPHWPVL 528

  Fly   683 NRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQ 727
            :...| ||.:...|.||...:...:.||.|.||.::.::...|.:
  Rat   529 DHDEQ-YLQLNSQPAVGRALKARRLQFWTKTLPQKIQELKGSQSK 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	175/601 (29%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	59/147 (40%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	173/587 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810