DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Ces5a

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001368779.1	Gene:	Ces5a / 67935	MGIID:	1915185	Length:	579	Species:	Mus musculus

Alignment Length:	599	Identity:	182/599 - (30%)
Similarity:	280/599 - (46%)	Gaps:	100/599 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 STTHHPERRHVVPDKLQYTQ--EIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRF 199
            |.|..|.|         ||:  .:|.||..::|         .|..|:.|||:|:|..|.|..||
Mouse    30 SVTEEPHR---------YTKLGWVQGKQATVLG---------RLEPVNVFLGIPFAAPPLGPLRF 76

  Fly   200 MPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLY 264
            ..|..|:||..|:.|...|.:|.|.|..|..:  :|:.:..:..|..        ||||||||:|
Mouse    77 SKPQPPIPWDNLREATAYPNLCFQNLEWLFIY--QNLLKVSYPILGM--------SEDCLYLNIY 131

  Fly   265 VP-HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDA 328
            .| |....|:   ..|:|::.|..||..|.:.:|||.|:.|.:|:|||:.||||:.||.... :.
Mouse   132 APCHANNGSS---LPVMVWIPGGGFETGSASIFDGSALAVYEDVLVVTIQYRLGIFGFFTTQ-NQ 192

  Fly   329 HNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSG 393
            |...|:|..||:|||.|::|||:.|||:...||:.|:|.||..::.|::||:::.||||||:.||
Mouse   193 HAPGNWAFWDQLAALLWVRENIKYFGGNPDSVTIFGNSAGAISISSLILSPLSADLFHRAIMQSG 257

  Fly   394 SA-MSDWAASNQSLQLTMQ-IAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFST 456
            .| :....:|:..|:..:| :|:..:|      ...|...||.|||.:...:::    :|:|.:.
Mouse   258 VAIIPSLKSSDNDLKHDLQVVANVCDC------NVSDSKALLKCLREKSSLELM----SLSQKAK 312

  Fly   457 SLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEE---GLRENERDNLL 518
            |...:|||.....:|.:::...|  ......:.|:...|..:.|......|   |..|:....|:
Mouse   313 SFTRVVDGSFFSEEPLELLSQKT--LKIVPSIIGVNNQECGYILPVRDTPEILLGSNESTALTLI 375

  Fly   519 RFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADV 583
            ...:..     |...|....|:|....::|   |::  ||.:||:..|...|.|.|.|..:|.|.
Mouse   376 HTLLHI-----PTQHLYIVTKEYFHGKHSP---TDI--RDTLLDLFGDVFFVVPGLVTARYHRDS 430

  Fly   584 NRRNYMYVFGH-----NSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNY------TVQEK 637
            ....|.|.|.|     .::...|....|:   :|:.|:||      |||..|:.      |.:||
Mouse   431 GGPVYFYEFQHRPHCFQNSRPAFVKADHT---DEIRFVFG------GPFLKGDVVMFEEATEEEK 486

  Fly   638 LLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDL-DWPEFNRRAQAYLNIGIPPTVGYK 701
            |||..:|.||.||.::|:|...                || .||.::...| ||.:.:..:.|.:
Mouse   487 LLSRKMMKYWANFARSGDPNGA----------------DLPPWPVYDENEQ-YLELDVNISTGRR 534

  Fly   702 YRQIYMNFWNKELP 715
            .:...:.||...||
Mouse   535 LKDQRVEFWTDTLP 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	174/576 (30%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	60/146 (41%)
Ces5a	NP_001368779.1	COesterase	33..543	CDD:395084	176/589 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910