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Protein Alignment Nlg1 and BCHE

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_000046.1	Gene:	BCHE / 590	HGNCID:	983	Length:	602	Species:	Homo sapiens

Alignment Length:	604	Identity:	175/604 - (28%)
Similarity:	262/604 - (43%)	Gaps:	106/604 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222
            |..|.|::.|:  ...|..|  .|..|||:|||:.|.|..||..|.:...|..:..|......|.
Human    34 IATKNGKVRGM--NLTVFGG--TVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCC 94

  Fly   223 QKLPDLSP--HGSENMSRARHKHLSRLLPYLRTE-SEDCLYLNLYVPHEEPQSTPKQYAVLVYLH 284
            |.:....|  ||||..:.             .|: ||||||||:::|..:    ||...||::::
Human    95 QNIDQSFPGFHGSEMWNP-------------NTDLSEDCLYLNVWIPAPK----PKNATVLIWIY 142

  Fly   285 GESFE--WNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIK 347
            |..|:  .:|.:.|||..|:....||||::|||:|.||||....:.....|..|.||..||.|::
Human   143 GGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQ 207

  Fly   348 ENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASN--QSLQLTM 410
            :||.||||:...|||.|.|.|||.|:..::||.:..||.||||.|||..:.||.::  ::...|:
Human   208 KNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTL 272

  Fly   411 QIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDIL-----HIPTALTQFSTSLGPIVDGHVIPNQ 470
            .:|....|      ..|::..::.|||::..|:||     .:|.. |..|.:.||.|||..:.:.
Human   273 NLAKLTGC------SRENETEIIKCLRNKDPQEILLNEAFVVPYG-TPLSVNFGPTVDGDFLTDM 330

  Fly   471 PYKVMGHYTEHFSRYDLLFGITESESYHTLAALA---------------LEEGLR-------ENE 513
            |..::  ....|.:..:|.|:.:.|....|...|               .:|||:       |..
Human   331 PDILL--ELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFG 393

  Fly   514 RDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGM 578
            ::::|..|.....|.||:                       .:|:.:.|::.|...:.|.|:...
Human   394 KESILFHYTDWVDDQRPE-----------------------NYREALGDVVGDYNFICPALEFTK 435

  Fly   579 FHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAV 643
            ..::.....:.|.|.|.|:..|:......:.|.|:.|:||.||..     ..|||..|::||.::
Human   436 KFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER-----RDNYTKAEEILSRSI 495

  Fly   644 MAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPT-VGYKYRQIYM 707
            :..|.||.|.|||.             |.......||.|....|.||.:....| :..|.|....
Human   496 VKRWANFAKYGNPN-------------ETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQC 547

  Fly   708 NFWNKELPDELNQIAAIQE 726
            .||....|..|.....|.|
Human   548 RFWTSFFPKVLEMTGNIDE 566

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.