DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and NLGN2

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	886	Identity:	260/886 - (29%)
Similarity:	380/886 - (42%)	Gaps:	207/886 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222
            :....||:.|:.|... ...|..|.||||:|||..|.|.|||.||.||..|.|::.|..|||.||
Human    44 VNTAYGRVRGVRRELN-NEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACP 107

  Fly   223 QKLPDLSPHG-----------SENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEE------- 269
            |.|     ||           ::|:..|        ..|::.:||||||||||||.|:
Human   108 QNL-----HGALPAIMLPVWFTDNLEAA--------ATYVQNQSEDCLYLNLYVPTEDGPLTKKR 159

  Fly   270 ------PQST----PKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRP 324
                  |..|    |.:..|:::|||.|:...:||.:|||||::||.|||.|:||||||||||..
Human   160 DEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLST 224

  Fly   325 SIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAI 389
            ...|.. .||.|||||.||.|:.|||..||||..|:|:.|...||:|||.|::|..:.|||.:||
Human   225 GDQAAK-GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAI 288

  Fly   390 LMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQF 454
            ..||:|:|.|:.:.|.|:.|..:|..:.|      :.||....::|||.:..::::.......::
Human   289 AQSGTAISSWSVNYQPLKYTRLLAAKVGC------DREDSAEAVECLRRKPSRELVDQDVQPARY 347

  Fly   455 STSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA-LEEGLR-------- 510
            ..:.||:|||.|:|:.|..:|  ....|..||:|.|:.:.|....:...| .|:|:.
Human   348 HIAFGPVVDGDVVPDDPEILM--QQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTV 410

  Fly   511 ENERDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILSDARVVGPLL 574
            .|..|||.. |.:.: |:     |..|:|   .||.:.....|.| .|..:|.:.:|.:.|.|.:
Human   411 SNFVDNLYG-YPEGK-DV-----LRETIK---FMYTDWADRDNGEMRRKTLLALFTDHQWVAPAV 465

  Fly   575 QTGMFHADVNRRNYMYVFGHN-SATG--PFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQE 636
            .|...|||.....|.|.|.|: .|.|  .:|...|   |:||.::||.|:..|......|::..:
Human   466 ATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAH---GDELPYVFGVPMVGATDLFPCNFSKND 527

  Fly   637 KLLSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPT 697
            .:||..||.|||||.|||:|..|    .|.|....:..|    ::.|.:||.:.:.||:||:.|.
Human   528 VMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVVWSKFNSKEKQYLHIGLKPR 588

  Fly   698 VGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVIT------GHMSKYGPRDHGAEDPVRT 756
            |...||...:.||.:.:|           .|.....|:.|      .:.:::.||
Human   589 VRDNYRANKVAFWLELVP-----------HLHNLHTELFTTTTRLPPYATRWPPR---------- 632

  Fly   757 LKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQA 821
                  .|:.|..|:......|       .||                           |..|:.
Human   633 ------PPAGAPGTRRPPPPAT-------LPP---------------------------EPEPEP 657

  Fly   822 PPETV------AKSEAT-MQLLIALITIIIVLNLLIYGTFLLRQRRR---RAKALPFP------A 870
            .|...      ::..:| :.:.:|:...::.||:|.:.....::.||   |.:.|..|      .
Human   658 GPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGV 722

  Fly   871 PKLGGTILSYDGAN---DEELKRCSKSRDG--------------DDSFVLEMTRKSNTYEAIKTG 918
            |. ||.:|...|..   :|||......|.|              ...:.|.:.|..:....:..|
Human   723 PG-GGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPG 786

  Fly   919 QRSLSCSTVDTHTKVCEWMSSQEAPKSGSFNTATPPPQPIL 959
            ..:|..|                     ......|||.|.|
Human   787 ALTLLPS---------------------GLGPPPPPPPPSL 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	213/596 (36%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	76/161 (47%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	213/596 (36%)
		Aes	<170..>268	CDD:223730	50/98 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668		11/94 (12%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835		7/38 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820