Protein Alignment Nlg1 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 847
• Identity: 238/847 - (28%)
• Similarity: 373/847 - (44%)
• Gaps: 178/847 - (21%)

  Fly   147 VVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGL 211
            ::..:.|| ..:....|::.|: |.......|..|:|:||:|||..|||.|||.||..|..|.|:
Human    38 LIDSQAQY-PVVNTNYGKIRGL-RTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGI 100

  Fly   212 KIARHLPPVCPQKLPDLSPHGSENMSRARH--------KHLSRLLPYLRTESEDCLYLNLYVPHE 268
            :.......||||.|.:.|         ..|        .:|..|:.|::.::|||||||:|||.|
Human   101 RNTTQFAAVCPQHLDERS---------LLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTE 156

  Fly   269 EPQSTPK---------------------QYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTV 312
            :..:|.|                     :..|:||:||.|:...:||..|||:|:|||.|||:|:
Human   157 DGANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITI 221

  Fly   313 NYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMV 377
            |||||:||||.....|.. .||.|||||.||.||:||:.|||||..|||:.|...||:||:.|.:
Human   222 NYRLGILGFLSTGDQAAK-GNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTL 285

  Fly   378 SPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQ 442
            |..:.|||.:||:.||:|:|.||.:.|..:.|..:|..:.|.:.:..:      :::|||::.|:
Human   286 SHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTD------MVECLRNKNYK 344

  Fly   443 DILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEE 507
            :::........:..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|      .|...:
Human   345 ELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGE------GLKFVD 401

  Fly   508 GLRENER---------------DNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-H 556
            |:.:||.               |||.. |.:.:..:|..:..         ||.:.....|.| .
Human   402 GIVDNEDGVTPNDFDFSVSNFVDNLYG-YPEGKDTLRETIKF---------MYTDWADKENPETR 456

  Fly   557 RDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPL 621
            |..::.:.:|.:.|.|.:.|...||......|.|.|.|:..:........|..|:|:.::||.|:
Human   457 RKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPM 521

  Fly   622 AAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDWPEF 682
            .......|.|::..:.:||..||.|||||.|||:|..|    .|.|....:..|    ::.|.::
Human   522 IGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVAWSKY 582

  Fly   683 NRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELP--DELNQIAAIQEQLQKPGQEVITGHMSKYGP 745
            |.:.|.||:||:.|.|...||...:.||.:.:|  ..||:|........|.....:|..  .||.
Human   583 NPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSF--PYGT 645

  Fly   746 RDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTN 810
            |               :.|:...||     |:..|                        :..:.|
Human   646 R---------------RSPAKIWPT-----TKRPA------------------------ITPANN 666

  Fly   811 SLESGEDHPQAPPETVAKSE------ATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFP 869
            ...|.:.|...|.:|....|      ..:.:.||:...::.||:|.:.....::.:||.:....|
Human   667 PKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRP 731

  Fly   870 APKLGGTILSYDGAND------EELKRCSKSRDGDDSFVLEMTRKSNTYEAIKTGQRSLSCSTVD 928
            :|:...|       ||      ||:            ..|:|.:..:.:|          |.::.
Human   732 SPQRNTT-------NDIAHIQNEEI------------MSLQMKQLEHDHE----------CESLQ 767

  Fly   929 TH 930
            .|
Human   768 AH 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	195/601 (32%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	197/605 (33%)