DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and nlgn3a

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_005157256.1	Gene:	nlgn3a / 562702	ZFINID:	ZDB-GENE-071219-1	Length:	878	Species:	Danio rerio

Alignment Length:	817	Identity:	244/817 - (29%)
Similarity:	377/817 - (46%)	Gaps:	143/817 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 YTQEIQVKQGRLMGITRRFQVTSG-LRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHL 217
            |...:..:.|:|.|  .|..:.|. |..|||:||:|||..|.|.:||:||..|..|.|:|.|.|.
Zfish    67 YYPTVNTQYGKLRG--ARVPLHSEILGPVDQYLGVPYATPPVGEKRFLPPEPPSSWSGIKNATHF 129

  Fly   218 PPVCPQKLPDLSPHGSENMSRARHK-HLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYA--- 278
            .|||||.:.:..|   |.|...... :|..:...::.::|||||||:|||.|:.:...|:..
Zfish   130 APVCPQNIHNAVP---EIMMPIWFTFNLDIVATSIQDQNEDCLYLNIYVPTEDVKRISKECTRKP 191

  Fly   279 -------------------------------------VLVYLHGESFEWNSGNPYDGSVLSSYGE 306
                                                 |:||:||.|:...:||..|||||:|||.
Zfish   192 NKKICRKGGTHSKKQGEDLSDNDGDEDEDIRDTGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGN 256

  Fly   307 VIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAAC 371
            |||:|:|:|:||||||.....|.. .||.|||||.||.||.|||..||||::|:|:.|...||:|
Zfish   257 VIVITLNFRVGVLGFLSTGDQAAK-GNYGLLDQIQALRWISENIGYFGGDSNRITVFGSGIGASC 320

  Fly   372 VNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCL 436
            |:.|.:|..:.|||||||:.||||:|.||.:.|.::.|..:|..:.|.:.:.::      ::|||
Zfish   321 VSLLTLSHHSEGLFHRAIIQSGSALSSWAVNYQPVKYTRLLAEKVGCNVLDTLD------MVDCL 379

  Fly   437 RHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLA 501
            |.:..::::.......::..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|....:.
Zfish   380 RKKSARELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQ--GEFLNYDIMLGVNQGEGLRFVE 442

  Fly   502 -ALALEEGLRENERDNLLRFYMQSRFDIRPD--LALAATLKKYQDMYNNPIKATNLE-HRDVVLD 562
             .:..|:|:..|:.|..:..::.|.:.. |:  ..|..|:|   .||.:.....|.| .|..::.
Zfish   443 NVVDSEDGVSGNDFDFSVSDFVDSLYGY-PEGKDTLRETIK---FMYTDWADRDNPETRRKTLVA 503

  Fly   563 ILSDARVVGPLLQTGMFHADVNRRNYMYVFGHN------SATGPFAHLPHSIMGEELAFIFGAPL 621
            :.:|.:.|.|.:.|...||......|.|.|.|:      .|....||      |:|:.::||.|:
Zfish   504 LFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAH------GDEVPYVFGIPM 562

  Fly   622 AAAGP---FPSGNYTVQEKLLSEAVMAYWTNFVKTGNPK--APWKGIFINSHALEWDRYDLDWPE 681
              .||   ||. |::..:.:||..||.|||||.|||:|.  .|....||::.|..::  ::.|.:
Zfish   563 --IGPTDLFPC-NFSKNDIMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFE--EVAWSK 622

  Fly   682 FNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELN---QIAAIQEQLQKPGQEVITGHMSKY 743
            :|.:.|.||:||:.|.|...||...:.||...:|...|   .........:.|..|.....:|.
Zfish   623 YNPQDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPLETTQNSLST- 686

  Fly   744 GPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTS 808
             .|.:|...|..|     :.|.:: |..:.||    .:..:|
Zfish   687 -KRPNGKAWPFNT-----KRPPMS-PAYNSES----GKEQWN----------------------- 717

  Fly   809 TNSLESGEDHPQAP--PETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAP 871
                  ||:.| .|  .|........:.:.||:...::.||:|.:.....|:.:||.:..|.|:|
Zfish   718 ------GEEEP-GPLVVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEQHPQPSP 775

  Fly   872 KLGGTILSYD-GANDEEL---------KRCSKSRDGD 898
            ....|....: .|.:||:         ..|.....||
Zfish   776 PRATTTNDVNRHAPEEEIMSLQVNQTHHECDAGPTGD 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	205/612 (33%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	76/184 (41%)
nlgn3a	XP_005157256.1	COesterase	69..651	CDD:306613	204/610 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920